Live Attenuated Vaccines
Arenavirus Genome Rearrangement for the Development of Live Attenuated Vaccines
... arenavirus live attenuated vaccines based on rearrangement of their viral ...licensed vaccines are available to combat arenavirus infections and antiarenaviral therapy is limited to the ...
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Rearrangement of Influenza Virus Spliced Segments for the Development of Live-Attenuated Vaccines
... highly attenuated in vivo, while they retained their immunogenicity and provided protection against a lethal challenge with wild-type ...effectively attenuated by the rearrangement of spliced segments and ...
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Isolation of an Infectious Endogenous Retrovirus in a Proportion of Live Attenuated Vaccines for Pets
... of live attenuated vaccines for ...using vaccines for both cats and dogs commercially available in Japan or the United ...veterinary vaccines for retroviruses should be ...
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Superior Protection from Live-Attenuated Vaccines Directed against Johne's Disease
... novel live-attenuated vaccine candi- dates with mutations in sigH and lipN (pgsH and pgsN, ...these vaccines are promising candidates to fight Johne’s disease in ...Both vaccines appeared to ...
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Viral Nucleic Acids in Live-Attenuated Vaccines: Detection of Minority Variants and an Adventitious Virus
... of live-attenuated vaccines, requiring viral am- plification, may result in reversion ...of attenuated OPV to VDPV therefore likely occurs during the multiple rounds of replication occurring ...
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Research Regarding some Live Attenuated Vaccines Used in Immunoprophylaxis of the Avian Infectious Bursitis
... The antibodies level recorded at 7th day post- vaccination is not consistent with the results obtained by other authors. Thus, in a study conducted during 1990-1992 in a poultry unit on broilers obtained both from ...
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Recurrent 6th nerve palsy in a child following different live attenuated vaccines: case report
... further live attenuated vaccines not be administered, even though the routine Australian immunization schedule includes a MMR vaccine (2 nd dose) at 4 years of age ...further live ...
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The safety of live-attenuated vaccines in patients using IL-1 or IL-6 blockade: an international survey
... Withholding live-attenuated vaccines in patients using interleukin (IL)-1 or IL-6 blocking agents is recommended by guidelines for both pediatric and adult rheumatic diseases, since there is a risk ...
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Influenza Viruses with Rearranged Genomes as Live-Attenuated Vaccines
... H5N1 vaccines induce limited immune responses and, in the case of live-attenuated influenza virus vaccines (LAIV), there are safety concerns regarding the possibility of reassortment between ...
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General Molecular Strategy for Development of Arenavirus Live-Attenuated Vaccines
... Viral attenuation via a codon deoptimization approach has been documented for several viruses, including arenaviruses (42– 46). This approach also avoids the incorporation of amino acid changes within the candidate LAV ...
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Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster Virus
... rotavirus vaccines, a “Jennerian” approach, similar to that used for smallpox, has been ...the attenuated virus must retain infectivity at the site of inoculation, whether the vaccine is given by oral or ...
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Development of rationally designed live attenuated vaccines for Lassa fever and Venezuelan equine encephalitis.
... experimental group (Figure 4). It is well documented that strong T cell-mediated immunity correlates with protection and positive clinical outcomes in experimentally infected NHPs and LF patients [159, 169, 239, 240]. ...
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Development of Live-Attenuated Arenavirus Vaccines Based on Codon Deoptimization
... protective live-attenuated vaccine to combat human-pathogenic ...of attenuated recombinant trisegmented arenavi- ruses expressing antigens from different human pathogens to fa- cilitate the ...
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Safety of live, attenuated oral vaccines in HIV-infected Zambian adults Oral vaccines in HIV
... these vaccines are safe in adults with severe immunodeficiency (although the bacterial strains are sensitive to ciprofloxacin and could be easily treated if symptoms ...parenteral vaccines are available (such ...
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Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever
... These differences may reflect the differences in dosing regimen; however, the different type of these T cell modules may suggest that M01ZH09 induced signatures of proliferating T cells possibly aiding serological ...
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Evaluation in mice of Brucella ovis attenuated mutants for use as live vaccines against B. ovis infection
... Since live attenuated vaccines have provided the best results in terms of protection against infections caused by other Brucella species [29-31], it is to be expected that an attenuated strain ...
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Live, Attenuated Coronavirus Vaccines through the Directed Deletion of Group-Specific Genes Provide Protection against Feline Infectious Peritonitis
... promising live attenuated vaccine candi- dates. Live attenuated vaccines are generally the most power- ful means of protection against viral diseases, as was demon- strated by the ...
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Complexities in predicting the immunogenicity of live attenuated influenza vaccines
... of live attenuated influenza vaccines Benjamin ...1. Vaccines and Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Road, ...
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Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines
... IMPORTANCE Emergent coronaviruses remain a significant threat to global public health and rapid response vaccine platforms are needed to stem future outbreaks. However, failure of many previous CoV vaccine formulations ...
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Evaluation of Live Attenuated Influenza A Virus H6 Vaccines in Mice and Ferrets
... wt virus in the lower respiratory tract. The vaccine induced antibodies that cross-reacted with heterologous viruses less well than with the homologous virus. The protective efficacy of the H6 ca vaccines was ...
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