Live attenuated virus vaccines
Live attenuated virus vaccines for respiratory syncytial and parainfluenza viruses: applications of reverse genetics
... administer vaccines in a sequential schedule, and the use of antigenic chimeric viruses as vaccines must be compatible with this sequential sched- ...employing live-attenuated RSV and PIV ...
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Comparison of Adjuvanted-Whole Inactivated Virus and Live-Attenuated Virus Vaccines against Challenge with Contemporary, Antigenically Distinct H3N2 Influenza A Viruses
... In the face of the vast antigenic diversity of IAV, not only in swine but also in humans and avian species, efforts have been focused on exploring mechanisms to potentiate immune responses to vaccine antigens to induce ...
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Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster Virus
... rotavirus vaccines, a “Jennerian” approach, similar to that used for smallpox, has been ...vaccine virus will induce a robust and broad adaptive immune response similar to the natural infection, but not the ...
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Rearrangement of Influenza Virus Spliced Segments for the Development of Live-Attenuated Vaccines
... influenza virus causing a contagious respiratory dis- ease which is most effectively prevented through ...influenza virus genome encode mRNA transcripts that are alternatively spliced to express two ...
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Evaluation of Live Attenuated Influenza A Virus H6 Vaccines in Mice and Ferrets
... wt virus in the lower respiratory ...homologous virus. The protective efficacy of the H6 ca vaccines was consistent with the data obtained from immunization of mice with the H6 wt virus ...ca ...
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Env-Independent Protection Induced by Live, Attenuated Simian Immunodeficiency Virus Vaccines
... monkeys, but a two- to threefold reduction was seen in the naive control monkeys (data not shown). Concordant with the laboratory findings, both naive control animals succumbed to AIDS-like disease. Monkey 8148SIV died ...
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Viral Nucleic Acids in Live-Attenuated Vaccines: Detection of Minority Variants and an Adventitious Virus
... of live-attenuated vaccines, requiring viral am- plification, may result in reversion ...of attenuated OPV to VDPV therefore likely occurs during the multiple rounds of replication occurring ...
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Arenavirus Genome Rearrangement for the Development of Live Attenuated Vaccines
... of live attenuated vaccine candidates offers several unique advan- tages over other current ...other live attenuated vaccine approaches currently li- censed, which are based on a limited ...
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Influenza Viruses with Rearranged Genomes as Live-Attenuated Vaccines
... influenza virus subtypes top the World Health Organization’s list for the greatest pandemic ...H5N1 vaccines induce limited immune responses and, in the case of live-attenuated influenza ...
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Complexities in predicting the immunogenicity of live attenuated influenza vaccines
... 3. Ambrose CS, Wu X, Jones T, Mallory RM. The role of nasal IgA in children vaccinated with live attenuated influenza vaccine. Vaccine 2012; 30:6794-801. 4. Forrest BD, Pride MW, Dunning AJ, et al. ...
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In Vitro Analysis of Virus Particle Subpopulations in Candidate Live-Attenuated Influenza Vaccines Distinguishes Effective from Ineffective Vaccines
... viruses to the action of IFN. Following the exposure of 1-day-old monolayers of primary CEKs to rChIFN- ␣ for 24 h at 38.5°C, the cell monolayers were challenged with PFPs of the respective viruses. An overlay of agarose ...
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Pathogenic Conversion of Live Attenuated Simian Immunodeficiency Virus Vaccines Is Associated with Expression of Truncated Nef
... high virus load and progression to SAIDS can occur in the absence of NAK ...which virus produced tNef was examined by immunoblot analysis of viruses recovered from infected ani- mals at different intervals ...
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Development of Live-Attenuated Arenavirus Vaccines Based on Codon Deoptimization
... human vaccines, resulted in two silent point mutations in each of the viruses that did not affect their attenuated phenotype either in cultured cells or in ...a virus genotype associated with ...
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Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines
... Similar to the ExoN and E proteins, NSP16 is conserved across the entire coronavirus family increasing its appeal as an attenuation target. While 2=O MTase activity impacts the immune response and pathogenesis, it is not ...
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General Molecular Strategy for Development of Arenavirus Live-Attenuated Vaccines
... recombinant virus will retain the same antigenic composition, and therefore immunogenicity potential, as the parental patho- genic ...of virus gene ex- pression caused by a well-defined genetic determinant, ...
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Persistence of Antibody After Administration of Monovalent and Combined Live Attenuated Measles, Mumps, and Rubella Virus Vaccines
... Retention of measles, mumps, and rubella antibodies 7.5 years after vaccination with combined live measles (Moraten) mumps (Jeryl Lynn)-rubella (HPV-77 duck) virus vaccine... The serum o[r] ...
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Isolation of an Infectious Endogenous Retrovirus in a Proportion of Live Attenuated Vaccines for Pets
... During evolution, the genomes of all animal species have been colonized by endogenous retroviruses (ERVs). ERVs are derived from the integration of the retrovirus genome (“pro- virus”) into the host germ line and ...
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Cross Protective Immune Responses Elicited by Live Attenuated Influenza Vaccines
... a virus particle are recognized by Fc receptors expressed on the macrophages, which then actively ingest the opsonized virus, playing a pivotal role in the clearance of the ...of virus-infected cells ...
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The Matrix Gene Segment Destabilizes the Acid and Thermal Stability of the Hemagglutinin of Pandemic Live Attenuated Influenza Virus Vaccines
... pandemic vaccines. We generated seven reassortant pandemic live attenuated influenza vaccines (pLAIVs) with the hem- agglutinin (HA) and neuraminidase (NA) genes derived from animal influenza ...
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Local and systemic antibody responses in high risk adults given live attenuated and inactivated influenza A virus vaccines
... A significantly larger proportion of CR37 (HlNi) but not CR48 (H3N2) virus vaccinees devel- oped a fourfold rise in nasal wash antibody than developed a serum antibody response (Table 2)[r] ...
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