lncRNA MEG3
LncRNA MEG3 promotes melanoma growth, metastasis and formation through modulating miR-21/E-cadherin axis
... [26]. lncRNA MEG3, located in the chromo- some 14 DLK1-MEG3 imprinting region, were down-reg- ulated in a variety of primary human cancers, including lung cancer, hepatocellular cancer, multiple ...
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Original Article Decreased expression of lncRNA MEG3 in breast cancer is associated with poor prognosis
... between lncRNA MEG3 expression and breast cancer (BC) clinicopathological characteristics and ...of lncRNA MEG3 in 257 BC specimens were determined by quantitative real-time PCR (qRT-PCR), to ...
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The lncRNA MEG3 downregulation leads to osteoarthritis progression via miR-16/SMAD7 axis
... [21]. LncRNA MEG3 also was found to function as a ceRNA of several miRNAs, for instance, miR-125a-5p in immune thrombocytopenic purpura [13], miR-770-5p in Hirschsprung’s disease ...between MEG3 in ...
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LncRNA MEG3 suppressed the progression of ovarian cancer via sponging miR-30e-3p and regulating LAMA4 expression
... 6 MEG3 promoted the expression of LAMA4 via sponging miR-30e-3p, and reversed the promoting effect of miR-30e-3p on the proliferation of SKOV3 and OVCAR3 ...between MEG3 and ...of MEG3 in healthy and ...
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LncRNA MEG3 enhances cisplatin sensitivity in non-small cell lung cancer by regulating miR-21-5p/SOX7 axis
... whether MEG3 had the similar function to regulate some miRNAs, Starbase ...in MEG3 (Figure 2A). To verify the direct binding between MEG3 and miR-21-5p, luciferase reporter plasmids containing the WT ...
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miR-506 attenuates methylation of lncRNA MEG3 to inhibit migration and invasion of breast cancer cell lines via targeting SP1 and SP3
... Many studies have shown that miR-506 functions as tumor suppressor in different types of malignant tumors [25, 26]. For instance, Chen et al. [27] reported that miR-506 inhibits colorectal cancer progression by targeting ...
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Original Article Long non-coding RNA MEG3 mediates high glucose-induced endothelial cell dysfunction
... an lncRNA which is suggested to function as a tumor ...whether MEG3 is a po- tential regulator and molecular biomarker of high glucose-induced endothelial ...dysfunction. LncRNA Meg3-specific ...
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Original Article Long non-coding RNA MG3 inhibits proliferation and migration of non-small cell lung carcinoma through regulating EGFR
... between lncRNA and NSCLC occurrence and development. LncRNA MEG3 was confirmed to be expressed in numerous normal tissues, however signifi- cantly downregulated or even undetectable was observed in a ...
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Long non-coding RNA MEG3 suppresses survival, migration, and invasion of cervical cancer
... of Meg3-rac1 by blast.ncbi.nlm.nih.gov prediction. (B) Meg3 inhibited the expression of rac1 at the mrna level in both hela and siha ...(C) Meg3 inhibited the expression of rac1 at the protein level ...
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Original Article MEG3 regulates the invasion and migration of lung cancer via targeting miR-219a and through MAPK pathway
... of MEG3 and found that p53 gene activity increased, suggesting that MEG3 P53 pathway may inhibit the proliferation and invasion of liver cancer cells, and promote its ...that MEG3 can play a role in ...
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Effect of lncRNA ANRIL silencing on anoikis and cell cycle in human glioma via microRNA-203a
... of lncRNA ANRIL in glioma have not been fully ...of lncRNA ANRIL in glioma tissue samples, positively correlated with ...of lncRNA ANRIL was negatively correlated with the anti-oncogene ...silenced ...
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Insights into long noncoding RNAs of naked mole rat ( Heterocephalus glaber ) and their potential association with cancer resistance
... HMM-HA, the powerful trigger for the early contact inhibition (ECI) observed in NMR cells [31, 32], medi- ates the cancer resistance in NMR [33]. A previous study revealed that the HA signaling triggering ECI in NMR is ...
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Original Article Overexpression of lncRNA-422 inhibits proliferation and invasion in colorectal cancer
... SW1116 cells were lysed with RIPA protein extraction reagent (Beyotime, Beijing, China) supplemented with a protease inhibitor cock- tail (Roche, CA, USA). Protein extracts (40 μg) were separated by 10% ...
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Identification of long non-coding RNAs biomarkers for early diagnosis of myocardial infarction from the dysregulated coding- non-coding co-expression network
... analyzed lncRNA expression profiles of 151 samples (80 AMI patients and 71 healthy samples) by repurposing two publicly available microarray expression datasets to determine whether there is significantly altered ...
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A novel long non-coding RNA-KAT7 is low expressed in colorectal cancer and acts as a tumor suppressor
... formed lncRNA microarray assays using “Agilent All- Human Genome Oligonucleotide Microarray (4 × 44 K)” (Bohai Biotechnology, Shanghai, China) according to the standard protocol of the expression profiling ...
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Temple syndrome in a patient with variably methylated CpGs at the primary MEG3/DLK1:IG-DMR and severely hypomethylated CpGs at the secondary MEG3:TSS-DMR
... of MEG3 and miR134-5p but also elevated expression of H19 and decreased ex- pression of GNAS A/B, it is likely that the MLID re- sulted in altered expression of relevant imprinted genes, contributing to the ...
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Original Article Down-regulation of long non-coding RNA LET is associated with poor prognosis in gastric cancer
... low lncRNA LET expression level had poorer overall survival than the high lncRNA LET expression group (P < ...of lncRNA LET in gastric cancer was significantly cor- related with patients’ survival ...
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A long noncoding RNA MAP3K1-2 promotes proliferation and invasion in gastric cancer
... following lncRNA MAP3K1-2 knockdown, which may further influence cell proliferation, differentiation, motility, stress response, apoptosis, and survival via the MAPK signaling ...
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Long noncoding RNA Braveheart promotes cardiogenic differentiation of mesenchymal stem cells in vitro
... the lncRNA-Bvht ...before lncRNA-Bvht transfection significantly downregulated the expressions of cardiac differentiation-associated genes and biomarkers of EMT, indicating that lncRNA- Bvht mediated ...
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Original Article High expression of long noncoding RNA AB073614 in colorectal cancer patients and its clinical significance
... The present study didn’t find obvious correla- tions of lncRNA AB073614 level with tumor size, lymphatic metastasis and vascular inva- sion in the multivariate logistic regression anal- ysis (Table 2). This might ...
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