Long-Chain Acyl CoA
Characterization of long-chain acyl-CoA synthetases which stimulate secretion of fatty acids in green algae Chlamydomonas reinhardtii
... Results: The cDNAs of two long-chain acyl-CoA synthetases (LACSs) genes were cloned from Chlamydomonas reinhardtii and named as cracs1 and cracs2. They showed different substrate adaptation in ...
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Renal response to short- and long-term exercise in very-long-chain acyl-CoA dehydrogenase-deficient (VLCAD−/−) mice
... To test whether the oxidation rate in the kidney of VLCAD −/− mice is influenced by increased energy demand or fasting, we measured the turnover rate of C16-CoA in mice during different conditions. As shown in ...
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Hypoglycemia, Hypotonia, and Cardiomyopathy: The Evolving Clinical Picture of Long-Chain Acyl-CoA Dehydrogenase Deficiency
... viral illness.7’2’ This is reminiscent of patients with carnitine palmityl transferase deficiency, an en- zyme defect in the transport of long-chain fatty acid esters of carnitine into m[r] ...
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Maternal sodium butyrate supplement elevates the lipolysis in adipose tissue and leads to lipid accumulation in offspring liver of weaning-age rats
... proteins long-chain acyl-CoA synthetase-1 (ACSL1), Acyl-CoA Synthetase-1 (ACSS1), stearyl coenzyme A dehydrogenase (SCD) ...
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Two bifunctional enzymes from the marine protist Thraustochytrium roseum: biochemical characterization of wax ester synthase/acyl-CoA:diacylglycerol acyltransferase activity catalyzing wax ester and triacylglycerol synthesis
... NADPH-dependent long-chain acyl-CoA reductase catalyzing the reduction of long-chain acyl-CoA to form the fatty aldehyde inter- mediate, an unidentified ...
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Abnormal nonshivering thermogenesis in mice with inherited defects of fatty acid oxidation
... short chain acyl CoA dehydrogenase, which is mutated in BALB/cByJ ...the long chain acyl CoA dehydroge- nase gene ( Acadl ) are also sensitive to the ...and long ...
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High affinity esterification of eicosanoid precursor fatty acids by platelets
... We have examined the relative rates of uptake of several fatty acids into washed, human platelets by measuring incorporation into cellular phospholipids. In the presence of 15 microM fatty acid-free albumin and with ...
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Grevengoed_unc_0153D_15339.pdf
... Long-chain acyl-CoA synthetase 1 (ACSL1) contributes more than 90% of total cardiac ACSL activity, but its role in phospholipid synthesis has not been ...the acyl-chain ...
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Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development
... C16:0- CoA was estimated to be ...to long-chain acyl- CoA esters compared to rAtACBP4 and rAtACBP5 may suggest that AtACBP6 interacts with acyl-CoA esters differently from ...
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PubMedCentral-PMC5408607.pdf
... which long-chain acyl-CoA synthe- tase (ACSL) isoforms would activate these molecules and whether the apparent FA substrate preferences of each ACSL isoform might differ depending on whether ...
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Fatal pitfalls in newborn screening for mitochondrial trifunctional protein (MTP)/long-chain 3-Hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency
... for long-chain fatty acid disorders has proven to be ...very-long-chain acyl-CoA dehydrogenase deficiency (VLCADD), the most common long-chain fatty oxida- tion ...
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Clinical and genetic characteristics of patients with fatty acid oxidation disorders identified by newborn screening
... very-long-chain acyl-CoA dehydrogenase (VLCAD) deficiency, 5 with medium chain acyl-CoA dehydrogenase (MCAD) deficiency, 1 with primary carnitine deficiency, 1 with ...
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Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency: Clinical Presentation and Follow-Up of 50 Patients
... HELLP syndrome in a series of 29 affected pregnan- cies, although they also found an increased fre- quency of intrahepatic cholestasis, preeclampsia, and pregnancy-induced hypertension. The frequencies of AFLP and HELLP ...
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Acyl-CoA dehydrogenase long chain expression is associated with esophageal squamous cell carcinoma progression and poor prognosis
... Notes: representative images of acaDl expression in normal esophagus tissues and escc sections of various clinical stages from ihc analyses (A). The average MOD of acaDl staining was analyzed between relative normal ...
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Non-invasive test using palmitate in patients with suspected fatty acid oxidation defects: disease-specific acylcarnitine patterns can help to establish the diagnosis
... medium chain- (MCADD, age 0 to 17 years), 6 very long chain- (VLCADD, age 0 to 4 years), 6 long chain hydroxy- (LCHAD, age 1 to 6 years), 3 short chain- (SCADD, age 10 to 13 ...
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Clinical outcome, biochemical and therapeutic follow-up in 14 Austrian patients with Long-Chain 3-Hydroxy Acyl CoA Dehydrogenase Deficiency (LCHADD)
... Long-term complications are present in 36%-57% (Table 2). In summary, the 5 children diagnosed clinic- ally (the three born before NBS was introduced) (Patient 1,2,3) and the two with false negative NBS results ...
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Effects of guanidine derivatives on mitochondrial function: I Phenethylbiguanide inhibition of respiration in mitochondria from guinea pig and rat tissues
... and long chain fatty acids by mitochondria from several tissues of guinea pigs and rats and observed the effects of phenethylbiguanide on these ...of long chain fatty acyl-CoA ...
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Ferroptosis, a new form of cell death: opportunities and challenges in cancer
... ACSL4: Acyl-CoA synthetase long-chain family member 4; AML: Acute myeloid leukemia; AMPK: Adenosine 5 ′ -monophosphate-activated protein kinase; ART: Artesunate; As-SLC7A11: Antisense lncRNAs; ...
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The effect of acyl-CoA synthetase long-chain family member 5 on triglyceride synthesis in bovine preadipocytes
... of acyl-CoA synthetase families (ACSs) that are indispens- able in the activation of fatty acids, and play a key role in mammalian metabolism of fatty acids (Nelson and Ackman, ...carbon chain length ...
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Malonyl-CoA metabolism in skeletal muscle
... of long chain fatty acyl-CoA and inhibits endogenous lipolysis (Hulsman et al, ...myocardial long chain acylcarnitine ...myocardial long chain acyl carnitine ...
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