Loss of function
A Comt1 Loss of Function Mutation Is Insufficient for Loss of Pungency in Capsicum
... Comt loss-of-function mutation would cause loss of pungency in ...enzyme function showed that the two COMTs had high similarity with the COMTs of other plant ...Comt1 ...
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Comparative Loss of Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of Paramyxoviridae and Pneumoviridae
... The availability of genome-scale loss-of-function screens has enabled an unbiased investigation of the role of cellular proteins in diverse processes (6, 7). As obligate intracellular parasites, viruses ...
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NALCN channelopathiesDistinguishing gain-of-function and loss-of-function mutations
... Our results complicate this picture further, since it appears that gain- or loss-of-function mutations in NALCN can lead to a CLIFAHDD diagnosis. The- se results are consistent with the overlap between ...
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Loss-of-function genetic diseases and the concept of pharmaceutical targets
... of loss-of-function (lof) genetic dis- eases are also well-suited to the concept of target-based drug ...cellular function resulting from the mutation may be pharmacologically corrected by either ...
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Loss-of-function ABCC8 mutations in pulmonary arterial hypertension
... overcomes disease-causing ABCC8 loss-of-function mutations. We observed variable functional recovery in vitro by diazoxide of each SUR1 mutant tested in our study of PAH patients with ABCC8 mutations. ...
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Connecting epithelial polarity, proliferation and cancer in Drosophila: the many faces of lgl loss of function
... ABSTRACT Loss of cell polarity is a prominent feature of epithelial ...its loss of function causes neoplastic growth of the imaginal tissues, larval epithelial organs from which adult structures ...
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Loss-of-function ABCC8 mutations in pulmonary arterial hypertension
... overcomes disease-causing ABCC8 loss-of-function mutations. We observed variable functional recovery in vitro by diazoxide of each SUR1 mutant tested in our study of PAH patients with ABCC8 mutations. ...
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Loss-of-function phenotype of a PKCθT219A knockin mouse strain
... their function is regulated by activa- tion of upstream kinases and/or by subcellular localization, which depends on kinase:lipid and kinase: protein interactions, enabling them finally to phosphor- ylate specific ...
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Characterization of a new mouse p53 variant: loss-of-function and gain-of-function
... Mutant Loss Of Activity Database provides 26 different TP53 activities, covering biochemical activity, structure, bio- logical activity and gain-of-function, to identify the func- tions of target p53 ...
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<p>Loss of HNF1α Function Contributes to Hepatocyte Proliferation and Abnormal Cholesterol Metabolism via Downregulating miR-122: A Novel Mechanism of MODY3</p>
... HNF1 α is a homeobox transcription factor expressed in pancreatic islets, liver, kidney and intestine. 4 HNF1 α de fi - ciency in pancreatic β -cell leads to impaired insulin secre- tion in response to glucose, resulting ...
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Shoot and root branch growth angle control - the wonderfulness of lateralness.
... rooting IR64 rice variety bearing a truncated DRO1 loss-of-function allele. DRO1 expression is repressed by auxin and in gravitropism assays, increased auxin levels at the bottom half of gravistimulated ...
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Endocytic receptor mediated control of morphogen signaling
... LRP5. Loss of LRP4 in mice results in abnormal limb development, renal agenesis and defects in neuromuscular junction (NMJ; see Glossary, Box 2) formation (Johnson et ...or loss-of-function ...
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Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium
... The SOS system is induced when damage to DNA occurs, producing single- stranded DNA. This attracts RecA, and the DNA-RecA complex facilitates expression of the SOS system by exposing the cleavage site of LexA, the main ...
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Genetic and Functional Investigation of Zn2Cys6 Transcription Factors RSE2 and RSE3 in Podospora anserina
... the function and the organization of RSE2 and RSE3, we conducted a saturated genetic screen based on the constitutive expression of the aox ...or loss-of- function mutations in rse2 or ...
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Does a loss of TDP-43 function cause neurodegeneration?
... [12]. Loss-of- function models have also been generated in non- mammalian species and all except the worm showed neuro- logical and neurodegenerative phenotypes ...the loss-of-function models ...
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Exploiting Entity BIO Tag Embeddings and Multi task Learning for Relation Extraction with Imbalanced Data
... In practical scenario, relation extraction needs to first identify entity pairs that have relation and then assign a correct relation class. How- ever, the number of non-relation entity pairs in context (negative ...
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Loss of Gαq impairs regulatory B cell function
... normal B cells, suggesting that Gαq is critically import- ant for maintaining control of peripheral B-cell tolerance induction and repressing autoimmunity [24]. However, the role of Gαq in Breg regulation remains ...
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Projecting the Knowledge Graph to Syntactic Parsing
... We present a syntactic parser training paradigm that learns from large scale Knowledge Bases. By utilizing the Knowledge Base context only during training, the resulting parser has no inference-time dependency on the ...
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Loss of Sox9 function results in defective chondrocyte differentiation of mouse embryonic stem cells in vitro
... Fig. 6. Loss of Sox9 function does not affect the formation of pre- cartilage condensations in vitro. In situ hybridization using an anti- sense probe detecting scleraxis mRNA (A,B,C) combined with ...
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Effects of a weight loss plus exercise program on physical function in overweight, older women: a randomized controlled trial
... muscle function and ...muscle function in the present study, as muscle strength was maintained among participants in the interven- tion ...physical function in frail, obese, older ...
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