M. bovis BCG
Differentiation of strains in Mycobacterium tuberculosis complex by DNA sequence polymorphisms, including rapid identification of M bovis BCG
... in M. bovis BCG (Table ...human M. bovis isolates from ...be M. bovis BCG by high-performance liquid chromatography (HPLC ...intravesical BCG for bladder ...
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Regulatory, pro-inflammatory and inhibitory human T-cell responses to M. bovis BCG : opposing T-cell forces in TB-vaccination
... Mycobacterium bovis bacillus Calmette-Guérin (M. bovis BCG), the only available and licensed TB-vaccine, was developed already in ...1921. BCG was derived from Mycobacterium ...
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Differential Live Mycobacterium tuberculosis-, M. bovis BCG-, Recombinant ESAT6-, and Culture Filtrate Protein 10-Induced Immunity in Tuberculosis
... the M. bovis BCG strain, are processed along the endosomal pathway, ac- tivating stronger responses of proinflammatory cytokines, such as TNF- ␣ , IL-2, and IL-6, than the responses activated by ...
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Inhibition of the Multiplication of Mycobacterium leprae by Vaccination with a Recombinant M. bovis BCG Strain That Secretes Major Membrane Protein II in Mice
... of BCG vaccination on childhood tuber- culosis was conducted and was found to be a highly cost- effective intervention ...with BCG at birth were at high risk of developing disseminated BCG disease ...
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Identification of Surrogates and Correlates of Protection in Protective Immunity against Mycobacterium bovis Infection Induced in Neonatal Calves by Vaccination with M. bovis BCG Pasteur and M. bovis BCG Danish
... that BCG vaccination of cattle induced memory CD4 ⫹ T cell pop- ulations with the capacity to kill infected macrophages (12) that may play important roles in protective immunity against virulent challenge, ...
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Lack of intracellular replication of M. tuberculosis and M. bovis BCG caused by delivering bacilli to lysosomes in murine brain microvascular endothelial cells
... of M. tuberculosis and M. bovis Bacille Calmette-Guérin (BCG) bacilli in murine brain microvascular endothelial cells ...intracellular M. tuberculosis, but not BCG bacilli, ...
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Mycobacterium bovis Bacillus Calmette-Guérin Induces CCL5 Secretion via the Toll-Like Receptor 2-NF-κB and -Jun N-Terminal Kinase Signaling Pathways
... of M. bovis BCG as well ... M Bay 11-7082 de- creased M. bovis BCG-induced CCL5 secretion by 91% ⫾ ...from M. bovis BCG-infected ...with M. ...
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Immune Reactivity of Mycobacterium Bovis (Strain BCG) and Mycobacterium Vaccae
... Interfron-γ, TNF-α and macrophage activation do not meet appropriately a virulent mycobacterial infection because these responses are activated with greater vigor by a virulent mycobacterial strain than by a low-virulent ...
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Differentiation between Mycobacterium bovis BCG-Vaccinated and M. bovis-Infected Cattle by Using Recombinant Mycobacterial Antigens
... Mycobacterium bovis and vaccination with M. bovis BCG could greatly assist in the diagnosis of early infection as well as enhance the use of tuberculosis vaccines on a wider ...of M. ...
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Flow Cytometric Detection of Gamma Interferon Can Effectively Discriminate Mycobacterium bovis BCG-Vaccinated Cattle from M. bovis-Infected Cattle
... strain M. bovis BCG produces significant protection (2, 3) but has been shown to have variable efficacy in cattle, as in ...of BCG such that it is now being considered for addi- tional trials ...
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Single Nucleotide Polymorphisms in the Mycobacterium bovis Genome Resolve Phylogenetic Relationships
... of M. bovis differentiate between ...of M. bovis and ...lent M. bovis strain AF2122/97 and the vaccine strain BCG Pas- teur, among which 158 SNPs separated all the ...
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Development of Diagnostic Reagents To Differentiate between Mycobacterium bovis BCG Vaccination and M. bovis Infection in Cattle
... with M. bovis BCG (2, 9, 31, 37), it is still the only realistic vaccine candidate which could be applied to the field situation in the short ...with BCG have been reported from New Zealand, ...
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A novel method for monitoring Mycobacterium bovis BCG trafficking with recombinant BCG expressing green fluorescent protein.
... wild-type BCG by both human bladder tumor cell line T-24 and mouse bladder tumor cell line MBT-2 ...wild-type BCG phagocytosis by both T-24 and MBT-2 cells in that maximal internalization was observed at 16 ...
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Recurrent bilateral Mycobacterium bovis necrotizing epididymitis: a case report
... as M. bovis, a mycobacterial species known to be intrinsically resistant to the first-line anti tuberculous drug pyrazinamide ...attenuated M. bovis BCG strain was confirmed with ...
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Extracellular and Cytosolic Iron Superoxide Dismutase from Mycobacterium bovis BCG
... of M. bovis BCG is not preceded by signal ...Although M. bovis BCG iron SOD appeared to be cytosolic as well as a secreted protein, it was not the product of autolysis, because ...
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Biochemical and structural characterization of mycobacterial aspartyl tRNA synthetase AspS, a promising TB drug target
... Compound 1, which has a 4-thiazolidinone core, was identified as an inhibitor of M. tuberculosis in a previous phenotypic screen [26]. Resistant mutants were isolated that showed a 46-fold increase in MIC against ...
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Use of Antigen-Specific Interleukin-2 To Differentiate between Cattle Vaccinated with Mycobacterium bovis BCG and Cattle Infected with M. bovis
... Mycobacterium bovis and in cattle vaccinated with Myco- bacterium bovis BCG and then experimentally challenged with pathogenic ...with M. bovis produced quantifiable levels of ...
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Use of Antigen-Specific Interleukin-2 To Differentiate between Cattle Vaccinated with Mycobacterium bovis BCG and Cattle Infected with M. bovis
... in BCG-vaccinated or control ...with M. bovis BCG, and 31 uninfected ...both BCG-vaccinated ...the BCG-vaccinated animals ...0.0001). M. bovis BCG vac- ...
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Tuberculosis Vaccine Types and Timings
... These results apart, there is optimism that an improved BCG candidate can be produced, but whether this can reduce the vari- ability classically seen with the existing vaccine will take time to determine. A ...
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Bacille Calmette Guérin (BCG) spondylitis with adjacent mycotic aortic aneurysm after intravesical BCG therapy: a case report and literature review
... diagnose BCG spondylitis, because its symptoms, laboratory findings, imaging results, and pathological findings are similar to usual tuberculous ...of BCG in- fection, it might be difficult to make a ...
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