MALDI-lmaging and Direct Tissue profiling
Examination of tumour tissues by direct MALDI mass spectrometry imaging and profiling
... by MALDI-MSI analysis of non-treated and AQ4N-treated xenograft tissue ...by MALDI-MSI analysis of intact proteins directly from tissue sections is in most cases low and results in the ...
281
MALDI-MS Direct Tissue Analysis of Proteins: Improving Signal Sensitivity Using Organic Treatments
... in MALDI direct tissue ...for direct analysis profiling on tissues as well as for MALDI imaging ...the tissue, like peptides/proteins present in the ...the tissue ...
29
MALDI MS imaging for direct drug distribution analysis
... 1 rim F.J. L^napier h spatial resolution and analyte specificity. Several groups have presented data on xenobiotic distribution within whole body sections since the first report by Rohner et al., 2005 and they showed the ...
294
Spatio-Temporal Metabolite Profiling of the Barley Germination Process by MALDI MS Imaging
... highly tissue-specific ...with tissue-specific localizations of their glycosylated, hydroxylated, and O-methylated ...olite profiling of a cereals ’ germination process over time by MALDI MSI ...
25
Plasma peptidome profiling of acute hepatitis E patients by MALDI-TOF/TOF
... Endogenous peptides have already been established as messengers, hormones or cytokines in many physiological processes. In addition, peptides can be derived from the turnover of blood or tissue proteins. ...
13
On-Tissue Protein Identification and Imaging by MALDI-Ion Mobility Mass Spectrometry
... with MALDI-ion mobility mass spectrometry ...conventional MALDI time-of-flight (TOF) mass ...conventional MALDI-TOF), which enables mass and time selected ion images and the identification of ...
10
Implementation of MALDI MS profiling and imaging methods for the analysis of real crime scene fingermarks
... Spectrometry Profiling and Imaging (MALDI MSP and MSI) 3 , Secondary Ion Mass Spectrometry (SIMS) 4 and Direct Analysis in Real Time (DART) 5 , with SALDI and DART being mostly used for chemical ...
19
Technical evaluation of MALDI-TOF mass spectrometry for quantitative proteomic profiling matrix formulation and application
... In this study, using an unbiased automatic mass spectrum acquisition protocol, we exam- ined how different sample-matrix spotting methods and matrix chemicals affect the reproducibility of peptide/protein ion signals ...
12
Molecular profiling of lung cancer specimens and liquid biopsies using MALDI-TOF mass spectrometry
... In summary, MS allows the genotyping of several sam- ples simultaneously by screening many known mutations in a single and cost effective test. It has high sensitivity, an important feature when a minority of mutant ...
9
MALDI-MSI: a fast and reliable method for direct melatonin quantification in biological fluids
... as MALDI mass spectrometry imaging (MSI), was devel- oped to identify the spatial distribution of compounds in any physical sample, such as tissue sections (Solon 2007), drug tablets (Earnshaw et ...
6
Analysis of Lipids in Kidney Tissue Using High Resolution MALDI Mass Spectrometry Imaging
... All MALDI MSI measurements and direct on-tissue MS/MS analysis in this thesis were carried out on a hybrid linear ion trap/orbitrap mass spectrometer fitted with a MALDI ion source that ...
127
Systematic profiling of spatiotemporal tissue and cellular stiffness in the developing brain
... have direct effects on fate determination in several cell types in ...developing tissue using the mouse embryonic cerebral cortex as an experimental ...of tissue and cellular stiffness with ...
6
MALDI-ToF mass spectrometry biomarker profiling via multivariate data analysis application in the biopharmaceutical bioprocessing industry
... MALDI-ToF Mass Spectrometry 86 ...the MALDI-ToF mass spectrometry platform was ...of MALDI coupled with ToF detection and its characteristic generation of mostly singly charged peptide and protein ...
271
Glycomic profiling of carcinoembryonic antigen isolated from human tumor tissue
... and MALDI-TOF-MS n ...for MALDI-TOF-MS n , all of the methods for structure analysis of CEA glycans mentioned above are sample/standard-consuming as well as ...contrast, MALDI-TOF-MS n is both ...
7
LESA FAIMS mass spectrometry for the spatial profiling of proteins from tissue
... resolution MALDI MSI experiments of smaller tissue areas, and in the analysis of various drug dosed animal ...brain tissue by nanospray desorption electrospray ionization (nanoDESI) at approxi- ...
10
Quality Control Based on Isotopic Distributions for High-Throughput MALDI-TOF and MALDI-FTICR Serum Peptide Profiling
... In profiling studies, the most commonly used mass analysis in combination with MALDI is time-of-flight mass spectrometry (TOF-MS) [29 –31] ...trometry, MALDI coupled with Fourier transform ion ...
11
Accurate identification of Culicidae at aquatic developmental stages by MALDI TOF MS profiling
... coluzzii, indicated that 8 and 4peaks could distinguish them at the L3 and P1 aquatic developmental stages, respectively. Although 97.3% (73/75) of the specimens from this Anopheles complex tested blindly were unam- ...
14
MALDI-MSI for the analysis of a 3D tissue-engineered psoriatic skin model
... [24]. MALDI-MSI is continuing to grow as a robust technique for the analysis of tissues and offers great prospects for tis- sue engineering to compare the profile of native tissues and diseases with those of their ...
8
MALDI MSI for the analysis of a 3D tissue engineered psoriatic skin model
... [24]. MALDI-MSI is continuing to grow as a robust technique for the analysis of tissues and offers great prospects for tis- sue engineering to compare the profile of native tissues and diseases with those of their ...
9
Tumor classification with MALDI-MSI data of tissue microarrays: A case study
... on tissue microarrays (TMAs) a large number of biomolecules can be studied for many patients at the same time, making it an attractive tool for biomarker ...from MALDI-MSI ...the MALDI-MSI ...
7