Mannose-Binding Lectin
Original Article Identification of mannose-binding lectin as a mechanism in progressive immunoglobulin A nephropathy
... Abstract: Immunoglobulin A nephropathy (IgAN), the pathogenesis of which remained still unclear is one of the lead- ing courses of end-stage renal disease in approximately 50% affected patients. On the basis of several ...
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Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease
... Rheumatic heart disease (RHD) is mediated by an abnormal immunological response following a Streptococcus pyogenes infection that induces a disturbance of oxidants and antioxidants balances. Mannose-binding ...
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Strong predictive value of mannose binding lectin levels for cardiovascular risk of hemodialysis patients
... plasma mannose-binding lectin (MBL) levels are associated with a higher incidence of cardiac (C-event) and cardiovascular events (CV- event) in hemodialysis (HD) ...
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Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity
... [9]. Mannose binding lectin (MBL) is an essential component of innate immunity that recognizes carbohydrate residues on the surface of micro-organisms, namely, bacteria, viruses, fungi, and protozoa, ...
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Elevated levels of vitamin D and deficiency of mannose binding lectin in dengue hemorrhagic fever
... One of the major pathways of complement activation is initiated by binding of the virus to mannose binding lectin (MBL). MBL is a pattern recognition molecule that recognizes specific sugar ...
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Deficiency of functional mannose binding lectin is not associated with infections in patients with systemic lupus erythematosus
... the lectin pathway of complement activation has also been suggested to play a role in the occurrence of infections in ...for mannose-binding lectin (MBL) variant alleles were at an increased ...
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Mannose Binding Lectin Genotypes Influence Recovery from Hepatitis B Virus Infection
... Mannose binding lectin (MBL) plays a central role in the innate immune response (32). mbl2, which encodes MBL, is located on chromosome 10 and consists of four exons (Fig. 1). Several ...
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Association of Mannose-Binding Lectin Gene Polymorphism but Not of Mannose-Binding Serine Protease 2 with Chronic Severe Aortic Regurgitation of Rheumatic Etiology
... to mannose-binding lectin (MBL) (27) encoded by the MBL2 gene in the chromosome region ...C-type lectin and a member of the collectin family, is a soluble pattern recognition receptor and ...
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A Single Asparagine-Linked Glycosylation Site of the Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein Facilitates Inhibition by Mannose-Binding Lectin through Multiple Mechanisms
... Mannose-binding lectin (MBL; also known as mannose- binding or mannan-binding protein [MBP]) is a Ca 2⫹ -depen- dent (C-type) serum lectin that plays an important role in ...
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Mannose-Binding Lectin Deficiency Facilitates Abdominal Candida Infections in Patients with Secondary Peritonitis
... Mannose-binding lectin (MBL) deficiency due to variations in the MBL gene is associated with increased susceptibility to infections. In this study, the association between MBL deficiency and the ...
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Association of mannose binding lectin gene polymorphisms with the development of pulmonary tuberculosis in China
... [2]. Mannose-binding lectin (MBL) is an acute-phase serum protein in the collection family that recognizes a pathogen by its carbohydrate recog- nition ...
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Association of mannose binding lectin 2 genotype and serum levels with prognosis of sepsis
... Severe sepsis and septic shock cause 30% to 50% of all deaths in intensive care units (ICUs) [1]. Numerous studies have suggested that individuals vary in their ability to resist infection [2-4]. Genetic variations, such ...
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Mannose Binding Lectin as a Diagnostic Marker for Coronary Artery Disease in Hypertensive Patients
... “MANNOSE BINDING LECTIN AS A DIAGNOSTIC MARKER FOR CORONARY ARTERY DISEASE IN HYPERTENSIVE PATIENTS” is the bonafide work done by me at Institute of Biochemistry, Madras Medical College under the ...
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Original Article Serum mannose-binding lectin levels in patients with ischemic stroke
... [2]. Mannose-binding lectin (MBL) can activate the complement system independent of antibodies via MBL-associated serine proteases, thereby initiating the so-called MBL pathway of comple- ment ...
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Mannose-binding lectin deficiency and acute exacerbations of chronic obstructive pulmonary disease
... of mannose-binding lectin deficiency ranged from ...had mannose-binding lectin concentrations below the normal range and we found no association between ...
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Mannose binding lectin does not explain the course and outcome of pregnancy in rheumatoid arthritis
... MBL: mannose- binding lectin; mon, months; OR: odds ratio; PARA Study: Pregnancy-induced Amelioration of Rheumatoid Arthritis Study; PCR: polymerase chain reaction; PP: postpartum; RA: rheumatoid ...
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Significance of mannose-binding lectin deficiency and nucleotide-binding oligomerization domain 2 polymorphisms in Staphylococcus aureus bloodstream infections: a case-control study
... Plasma mannose-binding lectin levels in ...plasma mannose-binding lectin levels in ...MBL, mannose-binding ...
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Molecular defects in the mannose binding lectin pathway in dermatological disease: Case report and literature review
... Mannose-binding lectin (MBL) and the Mannose-binding lectin-associated serine proteases (MASPs) are an essential aspect of innate immune responses that probably play an important ...
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Serum Mannose-Binding Lectin Concentration, but Not Genotype, Is Associated With Clostridium difficile Infection Recurrence: A Prospective Cohort Study
... To date, there have been no studies on the role of either MBL levels or MBL2 genetic variants with CDI, possibly because MBL is not thought to bind to the surface of C. dif fi cile [24]. However, there is growing evidence ...
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Association of mannose binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis
... Mannose-binding lectin (MBL) is a key factor in innate immunity, and lung infections are the leading cause of morbidity and mortality in cystic fibrosis ...
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