Matrix metalloproteinase-7
Matrix metalloproteinase 7 promoted Schwann cell migration and myelination after rat sciatic nerve injury
... of matrix metalloproteinase 7 (MMP7), a Schwann cell-secreted proteolytic enzyme, was robustly elevated in rat sciatic nerve segments after nerve ...
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Amperometric Biosensor of Matrix Metalloproteinase 7 Enhanced by Pd Functionalized Carbon Nanocomposites
... MMP-2: Matrix metalloproteinase-2; MMP-7: Matrix metalloproteinase-7; NSE: Neuron specific enolase; PBS: Phosphate buffer solution; Pd-CNCs: Pd-functionalized carbon ...
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Clinicopathological significance of matrix metalloproteinase-7 protein expression in esophageal cancer: a meta-analysis
... “matrix metalloproteinase 7” or “MMP-7 protein, human” or “matrix metalloproteinase-7” or “MMP-7” or “MMP 7” or “matrilysin” for the exposure fac- tors, and ...
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By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization
... To establish the involvement of c-Jun and NF-κB in the regulation of shear-induced MMP-7 mRNA synthesis, a series of MMP-7 promoter constructs were generated using the luciferase reporter plasmid, ...
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Matrix metalloproteinase 7–dependent release of tumor necrosis factor α in a model of herniated disc resorption
... Our results indicate that the MMP-7 substrate that is ultimately responsible for macrophage invasion and degradation of disc tissue is TNF-α. The presence of TNF-α in macrophage/disc cocultures was required for ...
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Matrix metalloproteinase 7 is expressed by pancreatic cancer precursors and regulates acinar to ductal metaplasia in exocrine pancreas
... Protein extraction and immunoblotting. For protein analy- sis, pancreatic tissues cut lengthwise from the suture point to the pancreatic tail were minced and solubilized in lysis buffer consisting of 50 mM Tris (pH 7.5), ...
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Original Article Expression and correlation of matrix metalloproteinase-7 and interleukin-15 in human osteoarthritis
... In the present study, the expression and corre- lation of MMP-7 and IL-15 in human OA was investigated. The results showed that the pro- tein, mRNA, and serum expression levels of MMP-7 and IL-15 in OA ...
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Serum Matrix Metalloproteinase-7 is an independent prognostic biomarker in advanced bladder cancer
... We previously developed and validated a homogeneous sandwich fluoroimmunoassay [18] based on the TRACE technology. The specific MMP-7 immunoassay was set up using two monoclonal anti-human MMP-7 anti- ...
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Matrix metalloproteinase-7 may serve as a novel biomarker for cervical cancer
... Currently, persistent HPV infection is recognized as the main cause of cervical cancer. HPV16 and HPV18 are the most carcinogenic HPVs. To date, the mechanism by which MMPs promote cancer cell invasion and migration is ...
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Elevated matrix metalloproteinase 7 expression promotes metastasis in human lung carcinoma
... main result of our analysis demonstrated a significant as- sociation between MMP-7 and TMN stages, histologic grade and LN metastasis of lung cancer but not between MMP-7 and histology. Glandular and ductal ...
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Matrix metalloproteinase 28, a novel matrix metalloproteinase, is constitutively expressed in human intervertebral disc tissue and is present in matrix of more degenerated discs
... on matrix synthesis and degradation in the disc have shown that proinflammatory cytokines, such as TNFα, are important cytokines involved in the pathogenesis of disc ...with matrix degradation via ...
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Original Article Expression of matrix metalloproteinase-8 and matrix metalloproteinase-13 in mast cells of human periapical lesions
... of matrix metalloproteinase-8 (MMP-8) and MMP-13 in mast cells (MCs) of human periapical lesions and to discuss the pathogenic role of MCs in periapical ...
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Serum Matrix Metalloproteinase 3 and Tissue Inhibitor Metalloproteinase 1 in Vascular Dementia: A Comparative Study
... of matrix metalloproteinase 3 (MMP3) and tissue inhibitor metallo- proteinase 1 (TIMP1) in vascular dementia patients and healthy control ...of matrix metalloproteinase 3 (MMP3) and tissue ...
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Effect of Aliskiren on renal using UUO mmp 3/timp 2 model
... of metalloproteinase-2 (TIMP-2) pointed out that, the renal rats with unilateral ureteral obstruction (UUO) model occur after interstitial fibrosis and renal tissue damage or may show Matrix ...
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Clinical evaluation of a matrix metalloproteinase 12 cleaved fragment of titin as a cardiovascular serological biomarker
... Extracellular matrix (ECM) components are degraded by a number of different proteases including matrix metalloproteinases (MMPs). MMP-degradation of pro- teins generates specific cleavage sites on fragments ...
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The triterpenoid CDDO inhibits expression of matrix metalloproteinase 1, matrix metalloproteinase 13 and Bcl 3 in primary human chondrocytes
... A synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO), has been reported to have anti-inflammatory properties and to decrease the interleukin-1 (IL-1)-induced expression of matrix ...
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The Distribution of Matrix Metalloproteinase-2, Tissue Inhibitor of Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-4 in Psoriatic Skin
... Psoriasis is common chronic inflammatory skin condition associated with significant comorbidities [1]. Genetic and immunologic studies suggest psoriasis is a T helper 1-type disease. The knowledge about the involvement ...
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The role of Heparin-binding proteins in normal pancreas and acute pancreatitis
... with matrix, membrane domains or cytoskeleton may not be solubilised, and so would not figure in the ...column matrix, and so such proteins will not be retained on the heparin affinity ...
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Increased matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 ratio in smokers with airway hyperresponsiveness and accelerated lung function decline
... Notes: aMs from ahr−ns (n=10), ahr−s (n=13) or ahr+s (n=8) were incubated for 24 hr. The level of MMP-9 (A) and TIMP-1 (B) in the culture supernatants was determined by enzyme-linked immunosorbent assays. The molar ratio ...
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Expression of CD147 and matrix metalloproteinase 11 in colorectal cancer and their relationship to clinicopathological features
... lular matrix metalloproteinase inducer (EMMPRIN), is a member of the immunoglobulin superfamily of adhesion ...secrete matrix metalloproteinases ...
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