Maximum dose
Bayesian designs of phase II oncology trials to select maximum effective dose assuming monotonic dose-response relationship
... lower dose that is suf- ficiently active and equally effective as higher ...the maximum tolerated dose (MTD) or the highest tried dose from the phase I trials if the MTD was not identi- fied ...
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Assessment of the robustness of volumetric-modulated arc therapy for lung radiotherapy
... rectangular dose grid of ...and maximum point dose in the plan were recorded for each shift and for the original clinical plan to determine the impact of the change in ...mean dose and spinal ...
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OptiMal PK: an internet based, user friendly interface for the mathematical based design of optimized anti malarial treatment regimens
... the maximum dose tolerated by patients and the minimum dose required to produce a therapeutic effect, (ii) the drug’s PK properties describing its clear- ance and volume of distribution (ultimately ...
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Original Article Clinical recommendations from an observational study on MERS: glucocorticoids was benefit in treating SARS patients
... starting dose of -160mg, mean dose in first three days of -160 mg, and daily maximum dose of -160 mg decreased more than a half of death risk in severe case according to theirs HRs which were ...
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In Silico Study of Pyrazolylaminoquinazoline Toxicity by Lazar, Protox, and Admet Predictor
... the maximum daily dose prediction, the smaller the maximum dose, the more toxic the ...The maximum daily dose could not be predicted for most compounds due to the lack of similar ...
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Preclinical research of the experimental preparation “Ferosel T”
... therapeutic maximum dose, the drug in the first 6 hours after administration slightly reduced the detoxi- fication function of the liver due to sodium selenite, which at a dose of ...
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Elucidating Ubiquitin Chain Formation Catalyzed by E2 Enzymes through use of a Di Ubiquitin Probe
... Each of the 65 samples was run through LC-MS three times. The chromatographic intensity values of the triplicate results were averaged to yield a single set of values per each m/z ratio. Next, we calculated the change in ...
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Preclinical radiation dosimetry for the novel SV2A radiotracer [18F]UCB-H
... and maximum dose for the TD, resulting more in a best and worst case scenario as opposed to a real ...absorbed dose and reported as %CV of the mean ...
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<p>Investigation of gold nanoparticle effects in brachytherapy by an electron emitter ophthalmic plaque</p>
... depth dose (PDD) versus distance from the plaque surface is shown for four situations in Figure ...the maximum dose in the nearest measuring point to the plaque surface ...tumor dose. ...
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A Study on Maximum Skin Dose in Cerebral Embolization Procedures
... the dose (defines areas of the patient’s skin where exposure should be avoided or minimized in future procedures) and the maximum dose; furthermore, they enable easy comparison between proce- dures ...
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*K. Shahul Hameed Maraicar and Thirumoorthy Narayanan
... accumulates maximum dose of Isoniazid in the lungs than other organs over prolonged period of time by enhanced Cmax and delaying the Tmax, which confirmed that inhalable SLN are suitable for targeting and ...
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A comparative study of the estimation of the maximum tolerated dose
... the maximum dose of a new pharmacological treatment with significant effect but that will not cause unacceptable adverse effect; commonly known as the maximum tolerated dose ...using ...
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Dosimetric Comparisons of Lung SBRT with Multiple Metastases by Two Advanced Planning Systems
... Purpose: To evaluate planning quality of Stereotactic body Radiotherapy (SBRT) with multiple lungmetastases generated by the Pinnacle and Tomotherapy planning systems, respectively. Me- thods and Materials: Nine randomly ...
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TOXICITY STUDY OF GAMBHARI PHALA CHURNA .......
... Gmelina arborea. is practically non toxic drug and its safety is thus established with the present study. Gambhari phala chunrna in the dose up to 2g/kg does not cause any kind of variations among behavior, ...
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From prescription drug purchases to drug use periods – a second generation method (PRE2DUP)
... average dose of a drug use period is modelled as the average DDD per day, as the purchased amount is recorded as DDDs in the prescription register, and is independent of changes in units (grams, milligrams, ...
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APPLICATION OF COAGULATION- FLOCCULATION FOR VEGETABLE TANNERY WASTEWATER SMITA S. BORCHATE, DR. G. S. KULKARNI, S. V. KORE, V. S. KORE
... optimum dose of polyelectrolyte is 65 ...the dose of 500 mg/L with ferric chloride provided 84% of COD removal and the removal efficiency of COD increased with using polyelectrolyte resulting in an ...
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Pomalidomide: a novel drug to treat relapsed and refractory multiple myeloma
... pomalidomide dose-level cohorts: 2 mg (n = 6); 3 mg (n = 8); 4 mg (n = 14); and 5 mg (n = ...four dose- limiting toxicities (grade 4 neutropenia) at 5 mg/day, the maximum tolerated dose was ...
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CT versus MR Imaging in Estimating Cochlear Radiation Dose during Gamma Knife Surgery for Vestibular Schwannomas
... Prevention of further tumor growth and the preservation of cra- nial nerve function are the main goals of SRS management of VS. During the past several years, multiple factors have been found to influence ...
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Phase I dose-escalation study of long-acting pasireotide in patients with neuroendocrine tumors
... open-label, dose-escalation study investigated the safety and tolerability, PKs/ pharmacodynamics, and preliminary efficacy of pasireotide LAR in patients with advanced ...a dose-escalation phase (n = 3–6 ...
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Reports of the Scientific Committee for Animal Nutrition Second Series 1980
... Considering the normal dose-levels of these additives in the daily ration, it was proposed - to fix the minimum and maximum content for flavophospholipol in complete feedingstuffs at 2 a[r] ...
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