MBP, myelin basic protein
Original Article Combination of Salidroside and hyperbaric oxygen improves leukoaraiosis through P13K/Akt signaling
... and MBP (myelin basic protein) staining were used to observe the changes of white matter myelin and oligodendrocytes, TUNEL was used to observe the apoptosis of oligoden- drocytes and ...
6
The spleen may be an important target of stem cell therapy for stroke
... cells; MBP: Myelin basic protein; MCP: Monocyte chemoattractant protein; MMP: Matrix metalloproteinase; MOG: Myelin oligodendrocyte glycoprotein; MSCs: Mesenchymal stem cells; ...
24
Structure and Expression of Myelin Basic Protein Gene Sequences in the mld Mutant Mouse: Reiteration and Rearrangement of the MBP Gene
... T h e values were normalized assuming that the copy num- ber of the 9.3-kb fragment was the same in wild type and mld (as determined above). T h e results are sum- marized in [r] ...
18
Early activation of CD4+ and CD8+ T lymphocytes by myelin basic protein in subjects with MS
... Methods: Whole blood samples from healthy human subjects were compared with samples from patients with multiple sclerosis (MS). In particular, the expression of CD69, a surface marker of T-lymphocyte activity, was ...
5
Decreased dependence of myelin basic protein reactive T cells on CD28 mediated costimulation in multiple sclerosis patients A marker of activated/memory T cells
... of myelin basic protein (MBP)-specific T cells, the activation state of these cells has not been well ...of MBP-reactive T cells on CD28-mediated co- stimulation in MS patients, healthy ...
7
Reactivity to myelin antigens in multiple sclerosis Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein
... major myelin proteins, myelin basic protein (MBP) and proteolipid protein (PLP), are likely to be of importance in the course of multiple sclerosis (MS), cell-mediated autoimmune ...
8
Kyratsous, Nikolaos (2016): Calcium signals in encephalitogenic T cells on their way into central nervous system tissues: an in vivo imaging study. Dissertation, LMU München: Medizinische Fakultät
... both myelin basic protein (MBP) specific encephalitogenic and OVA specific control T cells displayed similarly low frequent and short-lasting calcium ...antibody, MBP specific T cells ...
94
TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis
... naïve myelin-responsive repertoire and the ability of the DC to present the ...of myelin basic protein (MBP), unless they are first seeded with a cohort of naïve MBP-responsive T ...
5
Mannosylated linear and cyclic single amino acid mutant peptides using a small 10 amino acid linker constitute promising candidates against Multiple Sclerosis
... the myelin sheath ...of myelin proteins, such as myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and prote- olipid protein ...immunodominant ...
10
Monitoring chemically-induced myelin damages in the central nervous system via surface-recorded cerebellar auditory evoked potentials and radioimmunoassay of myelin basic protein in the cerebrospinal fluid
... LPC injection is evident from those studies. Hall’s (1972) experiment of injecting 0.2 pi, 1% LPC into the dorsal white matter of the adult mouse spinal cord showed that initial signs of myelin sheath disruption ...
220
Experimental allergic encephalomyelitis in cynomolgus monkeys Quantitation of T cell responses in peripheral blood
... to myelin basic protein (MBP), but not to proteolipid protein, were detected in peripheral blood mononuclear cells (PBMC) of all animals and persisted until their death or, in surviving ...
7
Original Article Comparison of neurovascular relationships between human pulp and rat pulp
... Abstract: The purpose of this study was to reveal the relationships of nerves and blood vessels between human and rat. Human premolar teeth, extracted for orthodontic reason, and rat maxilla and mandible were placed in ...
12
Autoimmunity-related demyelination in infection by Japanese encephalitis virus
... that myelin-specific antibodies appeared in sera, particularly in those mice with evident ...by myelin basic protein (MBP) was also shown in these ...e.g., MBP, of ...
6
Myelin in multiple sclerosis is developmentally immature
... assembled myelin sheath, either directly or indirectly resulting in ...involving protein chemical, mass spectrometric, and electron microscopic techniques we have determined that myelin obtained from ...
10
Modifications of myelin basic protein in DM20 transgenic mice are similar to those in myelin basic protein from multiple sclerosis
... the myelin proteolipid protein DM20 were pheno- typically normal up to 3 mo of age, after which the mice containing 70 copies of the transgene spontaneously demy- elinated and died at 10–12 ...in ...
11
Myelin basic protein specific T lymphocyte repertoire in multiple sclerosis Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones
... the myelin basic protein (MBP) has been studied with respect to T cell receptor (TCR) usage, HLA class II restriction elements, and epitope specificity using a total of 215 long-term ...
12
Beneficial effect of TNF-α inhibition on diabetic peripheral neuropathy
... in MBP expression was observed in the rhTNFR:Fc treated groups, implicat- ing that TNF-α is the main cause of the demyelination of the sciatic ...nerve. MBP is a strong basic membrane protein ...
9
Cyclic MOG₃₅–₅₅ ameliorates clinical and neuropathological features of experimental autoimmune encephalomyelitis
... ________________________________________________________________ EAE is induced to susceptible mice using linear peptides of myelin proteins of the central nervous system. Specific peptide motifs within the ...
23
In healthy primates, circulating autoreactive T cells mediate autoimmune disease
... Abbreviations used in this paper: APC, antigen-presenting cells; CNS, central nervous system; CSF, cerebrospinal fluid; EAE, experimental allergic encephalomyelitis; MBP, myelin basic pr[r] ...
8
Novel synthetic amino acid copolymers that inhibit autoantigen specific T cell responses and suppress experimental autoimmune encephalomyelitis
... were: MBP 85-99, ENPVVHFFKNIVTPR, molecular weight 1795; PLP 40-60, TGTEKLIETYF- SKNYQDYEYL, molecular weight 2603; and PLP 139- 151, HSLGKWLGHPDKF, molecular weight 1520; either unlabeled or with biotin linked to ...
10