MCD diet
Sex-specific metabolic interactions between liver and adipose tissue in MCD diet-induced non-alcoholic fatty liver disease
... an MCD diet, we examined visceral ...an MCD diet significantly reduced the mass of gWAT in male mice, whereas the same diet had no significant effect on the gWAT mass in female mice ...
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Sensitive and early detection of mitochondrial dysfunction in the liver of NASH model mice by PET imaging with 18F-BCPP-BF
... homeostasis in the liver during NASH progression [9]. Respiratory activity of MC-I isolated from NASH rats after 3 weeks on an MCD diet was unaltered relative to that in sham animals, but then declined at 7 ...
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Variations in hepatic lipid species of age-matched male mice fed a methionine-choline-deficient diet and housed in different animal facilities
... In WT1 NASH mice various PC and PE species were reduced. Indeed, only PE 36:5 was diminished whereas PE 40:6 was induced in the NASH liver of both animal groups. Another study by Najt et al. could not identify higher PE ...
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Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice
... Analysis of H&E staining of liver sections revealed that polydatin treatment protected MCD-fed mice from hepatic inflammation. Hepatic macrophage, central inflammatory mediators in the pathogenesis of NASH, ...
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Original Article Thyroid hormone attenuate nonalcoholic fatty liver disease via inducing autophagy in rats
... Abstract: Background and objective: To investigate whether thyroid hormone could influence the occurrence and/or reversal of steatosis and steatohepatitis induced by a MCD diet and elucidate its molecular ...
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AIMS In the present study, we evaluated whether RLX affects the development of liver fibrosis in
... the MCD diet; after 3 weeks, mice in group A received drinking water supplemented with RLX at the concentration of 25 µg /ml and dispensed in bottles refilled daily or earlier as needed, whereas group B ...
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Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis
... (MCD) diet, the degree of liver damage is related to dietary sugar content, which drives de novo lipogenesis and promotes the hepatic accumulation of saturated fatty ...the MCD model of fatty liver ...
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Effects of duodenal–jejunal bypass surgery in ameliorating nonalcoholic steatohepatitis in diet-induced obese rats
... (HF) diet (High Fat Diet Modified & Methionine/Choline Deficient Diet Pelleted; MP Biomedicals, Santa Ana, CA, USA) for 6 months (HF group, n = 6); 3) a MCD–HF diet for 3 months ...
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Original Article Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL/6 mice
... (MCD) diet in ...an MCD diet for 30 ...control diet was provided for 2 weeks after a period of 8, 16, or 30 ...the MCD diet for ≥2 weeks exhibited severe steatohepatitis ...
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Induction of heme oxygenase-1 protects against nutritional fibrosing steatohepatitis in mice
... Oxidative stress is an essential “second hit” in the pathogenesis of NASH, because increased free radicals can cause lipid peroxidation which induces inflamma- tory response and stellate cells activation, and further ...
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Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells
... Oleoylethanolamide (OEA), an endocannabinoid-like molecule, was revealed to modulate lipid metabolism through a peroxisome proliferator-activated receptor-α (PPAR-α) mediated mechanism. In present study, we further ...
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S100A4 Gene is Crucial for Methionine Choline Deficient Diet Induced Non Alcoholic Fatty Liver Disease in Mice
... in MCD diet-induced NAFLD mice, we performed HE staining, ORO staining, and Masson staining to assess hepatic inflammation and fibrosis by using NAS, to visualize lipid drop- lets, and to observe the ...
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Evaluating the efficacy of biological and conventional insecticides with the new ‘MCD bottle’ bioassay
... The first set of experiments examined how exposure time influenced the efficacy of a range of active ingredi- ents. Mosquitoes (An. stephensi) were exposed to one of the six treatments listed in Table 1 using the ...
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Medullary collecting duct acidification Effects of potassium, HCO3 concentration, and pCO2
... defined regulatory influences on MCD acidification as assessed by acute changes in the extracellular K and HCO3 concentrations and pCO2. These studies showed that acute changes in the peritubular K concentration ...
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Histopathological Study of Glomerular Disaese (in Patients with Significant Proteinuria): A Study of 50 Cases
... None of the patients with MCD had renal insufficiency and none of them had microscopic hematuria .675% of patients with MCD had proteinuria of nephritic range 225% patients had stage 1 h[r] ...
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Automated Cell Detection and Morphometry on Growth Plate Images of Mouse Bone
... morphometric MCD was measured in terms of inter- and intra-observer ...and MCD, and between adjacent zones of a given image, we used the t-test for each of the measured parameters, and the Dice index to ...
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Steganography in inactive frames of VoIP streams encoded by source codec
... Table 10 lists the MCD results of the stego speech files with information embedded in the inactive frames; each average MCD value in the third column is the arithmetic mean of MCDs obta[r] ...
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PROPERTY TAX REFORMS IN MUNICIPAL CORPORATION OF DELHI (MCD) – FISCAL AND DISTRIBUTIONAL IMPLICATIONS
... imperative. MCD in 2004 by introducing Unit Area Method (UAM) method was considered to increase the overall collection of the corporation by the way of property tax ...
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A CASE STUDY ON DELHI MCD ELECTION PREDICTION USING SOCIAL MEDIA ANALYTICS
... Twitter has been most prominently used for predicting the electoral outcomes in many instances. It has been observed that people comments and their sentiments keep on changing on the basis of electoral promotional ...
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Outcomes of Moral Case Deliberation - the development of an evaluation instrument for clinical ethics support (the Euro-MCD)
... of MCD can change in different contexts and over ...for MCD and developing an instrument. The contextual nature of MCD sessions prevents simple standardisation ...
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