Mcl-1
Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia
... and Mcl-1, down-regulation of X-linked inhibitor of apoptosis protein (XIAP) and survivin, up-regulation of endoplasmic reticulum (ER) stress response and induction of ...
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Mcl-1 is an important therapeutic target for oral squamous cell carcinomas
... whether Mcl-1 is a key survival factor in OSCC, we knocked down Mcl-1 genetically and with pharmacological inhibitors in the human OSCC line H357 and measured cell death in response to ...
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Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl 1
... kinase 1 (PINK1)-dependent poly- ubiquitination of multiple proteins on mitochondrial outer membranes, resulting in the removal of defec- tive mitochondria via ...member Mcl-1 underwent rapid Parkin- ...
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Dual modulation of MCL 1 and mTOR determines the response to sunitinib
... modulates MCL-1 levels by controlling its ubiquitylation and proteasomal ...of MCL-1. Since mTOR has been suggested to modulate the levels of MCL-1 protein, we explored the ...
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Mcl 1 dynamics influence mitotic slippage and death in mitosis
... of Mcl-1 levels, this suggests that while the APC/C-Cdc20 may contribute to Mcl-1 degradation during mitosis, it is not ...stabilize Mcl- 1 levels in mitosis ...in ...
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Expression and prognostic relevance of Mcl 1 in breast cancer
... expressed mcl-1 ...both mcl-1 and bcl-2 in >20% of tumour cells. Mcl-1 and bcl-2 proteins were both undetectable in only approximately 8% of ...expressed mcl-1 ...
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Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics
... that Mcl-1 levels determine sensitivity to both ABT-737 and ABT- 199 in acquired and inherently resistant leukemic cells [17, ...18]. Mcl-1 anti-apoptotic function in ABT-737- resistant ...
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Multiple myeloma induces Mcl-1 expression and survival of myeloid-derived suppressor cells
... and Mcl-1 expression after incubation with ...of Mcl-1, while pSTAT3 remained ...the Mcl-1 inhibitor MIM1 was able to completely abrogate the effect of MM-CM on the viability of ...
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Mcl 1 confers protection of Her2 positive breast cancer cells to hypoxia: therapeutic implications
... All Her2-positive BC patients eventually develop resist- ance to trastuzumab and other Her2 inhibitors. The pre- cise mechanism of resistance against these inhibitors remains elusive. We next investigated whether ...
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Anti apoptotic effects of osteopontin through the up regulation of Mcl 1 in gastrointestinal stromal tumors
... protein Mcl-1, was able to attenuate imatinib-induced apoptosis in GIST in vitro, suggesting a possible role of OPN and Mcl-1 in the mechanism underlying drug resistance to imatinib in GIST ...
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AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin
... of MCL-1 through AMPK-mTORC2- Akt/ERK axis. Knockdown of AMPK or MCL-1 enhances aspirin-induced apoptosis in HCC and colon cancer ...aspirin-induced MCL-1 ...
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Betulinic Acid-induced Mcl-1 Expression in Human Melanoma — Mode of Action and Functional Significance
... of Mcl-1 as an early response to DNA damage in cells that undergo an apoptotic response has been demonstrated ...of Mcl-1 may further enhance the thera- peutic potential of betulinic acid as a ...
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Inhibition of cyclin E1 sensitizes hepatocellular carcinoma cells to regorafenib by mcl-1 suppression
... and regorafenib by suppressing the expression of Mcl-1. To date, FLA, a first-generation CDK inhibitor, is the most widely investigated. In the past few years, there have been more than 60 clinical trials ...
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BRAFV600E -dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells
... and Mcl-1 stabilization in colon cancer cells, which in turn blocks the crosstalk from the death receptor to ...to Mcl-1, PI3K, RAF or MEK restores mTOR inhibitor-induced apoptosis by ...
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Original Article Correlation between Mcl-1 and pAKT protein expression in colorectal cancer
... minutes. After blocking with universal blocking serum (Ventana Medical Systems, Inc., Tucson, Arizona OMNIMAP) for 30 minutes, the samples were incubated with the primary antibodies at 4° C overnight. The samples were ...
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Comparison of Umbelliprenin and Auraptene in Cytotoxic Effects and Myeloid Cell Leukemia Type-1 (Mcl-1) Gene Expression
... using Mcl-1 primers (5′-CCA AGA AAG CTG CAT CGA ACC AT-3′ and 5′-CAG CAC ATT CCT GAT GCC ACC T-3′) and GAPDH primers (5′-GGA AGG TGA AGG TCG GAG T-3′ and 5′-GTC ATT GAT GGC AAC AAT ACC ACT-3′) as internal ...
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Low carbohydrate diet prevents Mcl-1-mediated resistance to BH3-mimetics
... and is associated with a poor prognosis [31]. Up to 80% of cancer patients will face cachexia and it is therefore not appropriate to reduce caloric intake in most of them. To circumvent this limitation and to benefit ...
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RANKL increases the level of Mcl 1 in osteoclasts and reduces bisphosphonate induced osteoclast apoptosis in vitro
... of Mcl-1 in osteoclasts probably occurred by proteasomal degradation since we also found that the proteasome inhibitor MG132 caused an increase in the level of Mcl-1 in mouse osteoclasts (data ...
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The role of glucocorticoid receptor phosphorylation in Mcl 1 and NOXA gene expression
... of Mcl-1, NOXA and Bim mRNA levels we employed qRT-PCR analysis (Figures 2, 3, ...of Mcl-1 mRNA was observed in CEM-C7-14 and CEM-C1-15 cells and five fold in A549 ...inhibited ...
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Silence of MCL-1 upstream signaling by shRNA abrogates multiple myeloma growth
... and MCL-1 was profiled by Western blot in hu- man 8226 myeloma cells transfected with shSTAT3-, shPI3K-, shMAPK1- or shMAPK3-bearing ...downstream MCL-1 pro- tein in the IL-6 treated 8226 ...
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