melanin synthesis
Original Article Effects of cathepsin B on proliferation, activation, and melanin synthesis of human hair follicle melanocytes
... This study indicated that cathepsin B showed obvious effects of promoting proliferation at 0.3 ng/mL cathepsin B, reaching the maximum at 0.6 ng/mL. Effects were decreased at 1.2 ng/mL compared with that at 0.3 ng/mL. ...
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Traditional herbal prescription LASAP C inhibits melanin synthesis in B16F10 melanoma cells and zebrafish
... 2]. Melanin biosynthesis can be inhibited by avoiding ultraviolet (UV) exposure, preventing melanocyte metabo- lism and proliferation, and blocking activities of enzymes such as tyrosinase ...sive melanin ...
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Metabolic engineering of Escherichia coli to optimize melanin synthesis from glucose
... a melanin production strain can be divided in two steps: First, metabolic engineering must be applied to increase carbon flow into the L-tyrosine biosynthetic ...
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Original Article Inhibitory effects of phenylethanoid glycosides on melanin synthesis in cultured human epidermal melanocytes
... The melanin and precipi- tate were solubilized by incubating with 100 µL of NaOH (1 M) at 37°C for 8 ...the melanin content was calculated according to the formula (1-ex- perimental group A470/blank group ...
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Whitening Effect of Storage Protein 2 from Silkworm Hemolymph
... In an effort to characterize SP2’s inhibitory effect and mechanisms, we investigated the influence of SP2 on the expression level of mRNA and enzymes involved in melanin synthesis as wel[r] ...
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N (4 methoxyphenyl) caffeamide induced melanogenesis inhibition mechanisms
... tyrosinase, microphthalmia-associated transcription factor (MITF), tyrosinase-related protein-1 (TRP-1), and tyrosinase- related protein-2 (TRP-2) [4, 6 – 8]. UV irradiation stimulates the secretion of α ...
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Evaluation of melanogenesis in A-375 melanoma cells treated with 5,7-dimethoxycoumarin and valproic acid
... Therefore, melanin synthesis, tyrosinase activity, and the expression of the tyrosinase gene are widely accepted as the main markers of melanocyte differentiation under in vitro conditions ...[32-34]. ...
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Isolation of Melanin Pigment Producing Bacteria from Marine Water and Study of Photoprotective Role of the Pigment
... form melanin from catechols to create high respiration rates necessary for protection of the nitrogenase system in nitrogen ...melanosome synthesis, and increases tyrosinase ...
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Effect of Hoechunyangkyeok San Extract on Melanogenesis
... the melanin contents in B161 melanoma cells and the pigmented equivalent with HMB45 and Fontana Masson staining in 3D skin ...regulating melanin synthesis and mela- nosome transport related proteins ...
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Cosmeceutical activities of ethanol extract and its ethyl acetate fraction from coffee silverskin
... cessive melanin; it also leads to the formation of dark spots and freckles, which affects people’s quality of life ...of melanin increased about ...trast, melanin synthesis decreased in groups ...
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Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects
... its synthesis is promoted by various stimulators such as UV irradiation, hormones, and cytokines ...convert melanin into different ...in melanin synthesis because it modulates the expression ...
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Phytochemical capacity of Nitraria retusa leaves extracts inhibiting growth of melanoma cells and enhancing melanogenesis of B16F10 melanoma
... N.retusa leaf extracts appear to contain compounds with, antiproliferative and apoptotic properties. The three tested extracts induced apoptotic effect by the activation of the extrinsic apoptotic pathway. As apoptosis ...
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Detecting human melanoma cell re-differentiation following BRAF or heat shock protein 90 inhibition using photoacoustic and magnetic resonance imaging.
... Developing biomarkers of drug activity is crucial for probing target modulation and treatment efficacy and hence clinical follow up 17,18 , with minimally invasive biomarkers of treatment response providing obvious ...
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Unraveling Melanin Biosynthesis and Signaling Networks in Cryptococcus neoformans
... in melanin production in ...effective melanin synthesis than those with lighter ...MEL, melanin production levels; KCR, YPD plus KCl; NCR, YPD plus NaCl; SBR, YPD plus sorbitol; KCS, YP plus ...
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Coral tumor-like growth anomalies induce an immune response and reduce fecundity
... multiple melanin-synthesis pathways (Mydlarz & Palmer 2011, Palmer et ...of melanin-synthesis — including mono-phenoloxidase, para-diphenoloxidase (laccase-type) and ortho-diphenoloxidase ...
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A novel gene from a secondary metabolism gene cluster is required for microsclerotia formation and virulence in Verticillium dahliae
... of melanin in Nag1-silenced mutants grown in Czapek-Dox salts ...medium. Melanin obviously accumulated in the wild- type strain, whereas no visible melanin could be ob- served in either Nag1-S3 or ...
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Journal of Applied Pharmaceutical Science
... showed melanin inhibitory activity in a dose- dependent manner and reach for 44% of inhibition at ...of melanin biosynthesis ...has melanin biosynthesis inhibition in B16 melanoma cells. This ...
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Recent advances in melanin-like nanomaterials in biomedical applications: a mini review
... In addition to the intrinsic fluorescent properties of melanin-like nanomaterials, these nanomaterials can be applied in biosensing applications as fluorescence quenchers. Wang et al. synthesized mesoporous pDA ...
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Thermoregulatory strategy may shape immune investment in Drosophila melanogaster
... less melanin may be deposited in the cuticle (due to less time available) and less PO produced (due to a greater PO efficiency at higher ...of melanin-based immunity ...
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Imaging of normal leptomeningeal melanin
... granular melanin not contained in ...of melanin is ...Melanosomic melanin is normally found only in the leptomeninges, where it is contained by ...
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