Melanocyte stimulating hormone
α Melanocyte stimulating hormone (α MSH) modulates human chondrocyte activation induced by proinflammatory cytokines
... α-Melanocyte-stimulating hormone (α-MSH) is an endogenous tridecapeptide that exerts multiple effects on host cells [5]. The natural peptide and its synthetic analogs inhibit inflammatory response in ...
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Anti-inflammatory and anti-invasive effects of alpha-melanocyte-stimulating hormone in human melanoma cells
... a-Melanocyte stimulating hormone (a-MSH) is known to have pleiotrophic functions including pigmentary, anti-inflammatory, antipyretic and immunoregulatory roles in the mammalian ...
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The experimental generation of antibodies to alpha melanocyte stimulating hormone and adrenocorticotropic hormone
... 1 Abbreviations: MSH, melanocyte stimulating hormone; ACTH, adrenocorticotropic hormone; RSA, rabbit serum albumin; anti-ACTH, serum from rabbits that have received injections of rabbit [r] ...
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Evaluation of polydentate picolinic acid chelating ligands and an α-melanocyte-stimulating hormone derivative for targeted alpha therapy using ISOL-produced 225Ac
... Ac. Finally, a pilot in vivo study with the 225 Ac-DOTA-CycMSH conjugate on tumour- bearing mice was performed to establish the feasibility of using ISOL-derived 225 Ac to drive preclinical radiopharmaceutical ...
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The α-melanocyte stimulating hormone/peroxisome proliferator activated receptor-γ pathway down-regulates proliferation in melanoma cell lines
... Background: The α -Melanocyte Stimulating Hormone ( α MSH)/Melanocortin-1 receptor (MC1R) interaction promotes melanogenesis through the cAMP/PKA pathway. The direct induction of this pathway by ...
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Alpha melanocyte stimulating hormone reduces endotoxin induced liver inflammation
... -Melanocyte–stimulating hormone (MSH) is a potent anti- inflammatory agent in many models of inflammation, sug- gesting that it inhibits a critical step common to different forms of ...
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Preclinical Melanoma Imaging with 68Ga-Labeled α-Melanocyte-Stimulating Hormone Derivatives Using PET
... The melanocortin 1 receptor (MC1R) is highly expressed in malignant melanomas. It has been shown to be expressed in 83% of melanoma cell lines, all tissue samples from primary and metastatic melanomas (n = 26) [9], and ...
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Alpha melanocyte stimulating hormone protects against renal injury after ischemia in mice and rats
... -Melanocyte-stimulating hormone ( a -MSH) is a potent anti–inflammatory agent that inhibits neutrophil mi- gration and production of neutrophil chemokines and ...
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Genetic disruption of γ melanocyte–stimulating hormone signaling leads to salt sensitive hypertension in the mouse
... The g-melanocyte-stimulating hormone (g-MSH) is a natriuretic peptide derived from the N- terminal region of proopiomelanocortin (POMC). Evidence suggests that it may be part of the coordinated ...
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Melanoma cell migration is upregulated by tumour necrosis factor-alpha and suppressed by alpha-melanocyte-stimulating hormone
... a-Melanocyte-stimulating hormone had an inhibitory effect on TNF-a- stimulated migration for HBL cells, completely blocking migration at 10 9 M ...
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α-melanocyte stimulating hormone modulates the central acyl ghrelin-induced stimulation of feeding, gastrointestinal motility, and colonic secretion
... ICV injection of acyl ghrelin elicited food intake, accelerated gastric emptying, increased the geometric center and running percentage of small intestinal transit, decreased C[r] ...
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In vivo multiplex quantitative analysis of 3 forms of alpha melanocyte stimulating hormone in pituitary of prolyl endopeptidase deficient mice
... Neuropeptide hormones involve multiple maturation steps, including cleavage by proteases, multiple post- translational modifications and deactivation or degrada- tion processes. Further, rapid perturbations of the neu- ...
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The increase of alpha-melanocyte-stimulating hormone in the plasma of chronic fatigue syndrome patients
... assay. Plasma a-MSH levels were measured using a commercial radioimmunoassay kit (Eurodiagnostica, Malmö, Sweden). The minimum detectable concentra- tion of a-MSH was 3.9 pg/mL and the intra- and inter- assay ...
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High Polymorphism at the Human Melanocortin 1 Receptor Locus
... in the human melanocyte stimulating hormone receptor locus are associated with red hair and fair skin in humans. Thody et[r] ...
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Multiple feedback regulatory loops upon rat hypothalamic corticotropin releasing hormone secretion Potential clinical implications
... corticotropin-releasing hormone (CRH) neuron is regulated by CRH, by products of the proopiomelanocortin (POMC) gene, and/or by glucocorticoids, we used a rat hypothalamic organ culture system in which rat CRH ...
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Behavioural and neuroendocrine effects of environmental background colour and social interaction in Arctic charr (Salvelinus alpinus)
... In salmonid fish, a darker skin colour has been suggested to signal social subordination. Substratum colour is another factor affecting skin pigmentation in fish; in the present experiment, juvenile Arctic charr ...
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Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery
... This research was designed for in vivo concept testing for this drug delivery platform using two modular nanotransporters, one targeted to the α -melanocyte-stimulating hormone[r] ...
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Selective targeting of melanoma by PEG-masked protein-based multifunctional nanoparticles
... Results: Our HFt-based nanoparticle constructs functionalized with the α -melanocyte- stimulating hormone peptide moiety and polyethylene glycol molecules were specifically take[r] ...
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Overcoming Diminished Motivation
... Poster: Alpha-Melanocyte-stimulating Hormone Enhances Flank Marking Behavior in Male Syrian Hamsters by Activating Arginine Vasopressin AVP V1a Receptors.. Poster: Microinjection of argi[r] ...
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Equine pituitary pars intermedia dysfunction: current perspectives on diagnosis and management
... Abstract: Equine pituitary pars intermedia dysfunction (PPID) is a neurodegenerative disease of the hypothalamus, resulting in the loss of dopaminergic inhibition of pars intermedia. An oxidative stress injury of unknown ...
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