Merozoite surface
Exposure of the Plasmodium falciparum clonally variant STEVOR proteins on the merozoite surface
... the surface of schizont IE using the anti- PFL2610w antibody which localized STEVORs to the surface of the ...the surface of the schizont ...with surface expression STEVORs were detected on ...
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Plasmodium falciparum merozoite surface protein 1: Antigenicity, immunogenicity and structure.
... the merozoite surface and the erythrocyte ...The merozoite then reorients so that its apical end, which contains organelles (rhoptries and micronemes), comes in contact with ...
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Genetic polymorphism of merozoite surface protein 2 and prevalence of K76T pfcrt mutation in Plasmodium falciparum field isolates from Congolese children with asymptomatic infections
... Genotyping of merozoite surface protein-2 (msp2) is the commonly used method to study the genetic diversity of P. falciparum. This gene presents polymorphisms in the number of repeats and sequence type [6]. ...
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Identification and characterization of Pv50, a novel Plasmodium vivax merozoite surface protein
... other merozoite surface GPI-anchor ...in merozoite invasion of red blood cells ...parasite surface proteins as well as with host cell encoded ...vivax merozoite surface protein ...
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Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non polymorphic domains
... MSP2 is a glycosylphosphatidylinositol (GPI)-anchored protein present on the merozoite surface consisting of about 200–250 amino acids, encoded by a single exon on chromosome 2. It contains conserved N- and ...
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Identification of a novel merozoite surface antigen of Plasmodium vivax, PvMSA180
... the merozoite surface of schizont‑ stage parasites, and pvmsa180 sequences originating from various geographic regions worldwide showed low genetic ...
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Genetic diversity of the merozoite surface protein 3 gene in Plasmodium falciparum populations in Thailand
... An alternative approach for malaria intervention is to develop vaccines against the pathogenic erythrocytic stages, aiming to reduce their ability to induce morbidity and mortality. The erythrocyte invasion is a critical ...
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Immunogenicity of a chimeric Plasmodium falciparum merozoite surface protein vaccine in Aotus monkeys
... There is mounting agreement in the field that an effec- tive malaria vaccine will require induction of immune responses to multiple, distinct target antigens. This con- cept is central in the development of whole ...
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Polymorphic patterns of the merozoite surface protein 3β in Korean isolates of Plasmodium vivax
... The P. vivax merozoite surface protein-3 (PvMSP-3) family consists of several related proteins, PvMSP-3α, PvMSP-3β and PvMSP-3γ. Although the level of shared amino acid sequence identity among the proteins ...
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IMMUNOGENICITY OF THE MEROZOITE SURFACE PROTEIN-1 (MSP-1) OF HUMAN PLASMODIUM SP.
... the merozoite surface membrane of the Plasmodium parasite via the glycosyl-phosphatidyl- inositol (GPI) anchor (22, ...the surface in a fully soluble form (26, 27), whereas membrane-bound MSP-1 19 ...
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Genetic polymorphism of merozoite surface protein 1 and merozoite surface protein 2 in Plasmodium falciparum isolates from Brazzaville, Republic of Congo
... The present study was aimed at analysing genetic diversity of Plasmodium falciparum merozoite surface proteins 1 and 2 MSP-1 and MSP-2 and to determine the multiplicity of infection in c[r] ...
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Characterization of Pv92, a novel merozoite surface protein of Plasmodium vivax
... a merozoite surface protein, and this protein is ex- pressed at the late schizont stage, but no study of Pv92, the orthologue of Pf92 in ...the merozoite surface localization and antigenicity ...
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Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein 1 (MSP142) administered intramuscularly with adjuvant system AS01
... Abstract Background: The development of an asexual blood stage vaccine against Plasmodium falciparum malaria based on the major merozoite surface protein-1 MSP1 antigen is founded on the[r] ...
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Cloning and Sequence Analysis of Recombinant Plasmodium vivax Merozoite Surface Protein 1 (PvMSP-142 kDa) In pTZ57R/T Vector.
... er than the PvMSP-3ß gene (100% vs. 95%). They concluded that the PvMSP-3ß gene can- not be a suitable marker for detection of P. vivax in blood sample by PCR (22). One of the prominent problems in diagnostic kits is ge- ...
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Merozoite surface protein-7. A novel protein on the surface of Plasmodium falciparum merozoites
... the merozoite surface, passing through pellicular membranes, to release their contents by exocytosis into the parasitophorous ...erythrocyte surface antigen (RESA) which either crosses the PVM to ...
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Changing pattern of the genetic diversities of Plasmodium falciparum merozoite surface protein 1 and merozoite surface protein 2 in Myanmar isolates
... falciparum merozoite surface protein-1 (PfMSP-1) and -2 (PfMSP-2) are major blood-stage vaccine candidate antigens, which play important roles in erythrocyte inva- sion [6, 7], and are targeted by host ...
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Molecular identification and antigenic characterization of a merozoite surface antigen and a secreted antigen of Babesia canis (BcMSA1 and BcSA1)
... Background: Babesia canis is an apicomplexan tick-transmitted hemoprotozoan responsible for causing canine babesiosis in Europe and west Asia. Despite its importance, there is no known rapid diagnostic kit detection of ...
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Polymorphism in two merozoite surface proteins of Plasmodium falciparum isolates from Gabon
... A multi-immune response approach Washington, D.C.: ASM Press 1996, 77104 Smythe JA, Coppel RL, Brown GV, Ramasamy R, Kemp DJ and Anders RF Identification of two integral membrane protein[r] ...
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Immunization with a Plasmodium falciparum merozoite surface antigen induces a partial immunity in monkeys
... Saimiri monkeys immunized with a Plasmodium falciparum merozoite polypeptide of 41 kD mol wt are resistant to a blood challenge infection that induces a fulminant infection in control monkeys. The sera of the ...
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Genetic polymorphism of merozoite surface protein 1 and merozoite surface protein 2 in Plasmodium falciparum field isolates from Myanmar
... size of 190 kDa, that plays an important role in erythro- cyte invasion by the merozoite [4]. The protein is a prin- cipal target of human immune responses [5-7] and is a promising candidate for a blood stage ...
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