Mesenchymal stem cell chondrogenesis
Enhancement of mesenchymal stem cell chondrogenesis with short term low intensity pulsed electromagnetic fields
... to promote chondrogenesis (Fig. 2). We found that exposing MSCs once at the commencement of chondrogenic differentiation (1x) was necessary and sufficient to induce chondrogenic gene expression (Fig. 2A), which ...
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Enhancing Mesenchymal Stem Cell Chondrogenesis for Cartilage Tissue Engineering
... before chondrogenesis had developed or deposition of local ECM had occurred, however, others have suggested that these initial phenotypic transitions may regulate MSC response to physical ...embryonic stem ...
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Hypertrophy is induced during the in vitrochondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein 2 and bone morphogenetic protein 4 gene transfer
... on chondrogenesis and osteogenesis depending on the type of cell analyzed ...muscle-derived stem cells was shown to improve cartilage repair in rat osteochondral defects [40] and also when it was ...
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The role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cells
... regulate chondrogenesis and osteogenesis of mesenchymal stem cells ...how stem cells sense their mechanical environment, how these signals are translated into a cascade of biochemical events ...
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Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors
... Comparative array analysis of expanded MSCs from diff erent sources was published by several groups and provided, overall, very similar expression profi les of MSC populations [44,47,48,65-67]. Interestingly, ...
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Cell number in mesenchymal stem cell aggregates dictates cell stiffness and chondrogenesis
... in chondrogenesis (Additional file 1: Figure ...complex cell-mediated process [69–71], we therefore quantified the amount of soluble FN in the conditioned media of the aggregates at different time points ...
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Melatonin rescued interleukin 1β-impaired chondrogenesis of human mesenchymal stem cells
... OA has been thought of as a degenerative disease of the cartilage for a long time; however, increasing evi- dence suggests that inflammation plays a pivotal part in its pathogenesis. Inflammation takes part in the early ...
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Extracellular vesicles from human mesenchymal stem cells expedite chondrogenesis in 3D human degenerative disc cell cultures
... serum-free media (MSC NutriStem XF medium, Bio- logical Industries, Kibbutz Beit-Haemek, Israel). Condi- tioned media (CM) were collected every 48 h, and the cells were passaged at 90% confluency. CM collected were ...
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Hypoxic condition enhances chondrogenesis in synovium-derived mesenchymal stem cells
... multi-lineage cell types such as osteocytes, chondrocytes and adipocytes ...promising cell source for the repair and regeneration of cartilage ...appropriate cell source that is easily accessible, ...
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The effect of reduced glutathione on the chondrogenesis of human umbilical cord mesenchymal stem cells
... seed cell is the premise condition of cartilage tissue ...different stem cell types, such as MSCs [1], to generate chondrocytes in vitro, the long-term aim being to deter- mine if ...
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Exosomes from bone marrow mesenchymal stem cells enhance fracture healing through the promotion of osteogenesis and angiogenesis in a rat model of nonunion
... angiogenesis, stem cell differentiation, osteogenesis and chondrogenesis [1, ...Recently, mesenchymal stem cell (MSC) transplantation has been shown to be effective in ...
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Yes associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells
... of chondrogenesis in MSCs requires high cell density mimicking embryonic mesenchymal condensa- tion, for example by culturing cells in ...high cell density through phosphorylation at key amino ...
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1. Study of chondrogenesis in murine mesenchymal stem cells as a cell therapy in cartilage repair by in silico approach
... The transcription factors responsible for chondrocyte differentiation through literature search from Springer, PubMed, American Journal of biochemical engineering, Medica Odontologica 1.2.The collected transcription ...
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Chondrogenesis and integration of mesenchymal stem cells within an in vitro cartilage defect repair model
... resulting cell suspension was then filtered through a 40µm pore-size cell sieve (Falcon Ltd, Sarstedt, Ireland) and the filtrate centrifuged and rinsed with PBS ...
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Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells
... developing cell based therapies for cartilage ...enhance chondrogenesis, resulting in the formation of a more functional cartilaginous ...inhibit chondrogenesis of MSCs in the presence of ...
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Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury
... pluripotent stem cells (iPSC) are pluripotent stem cells generated by reprogramming somatic cells ...pluripotent stem cell-derived mesenchymal stem cells, iMSC), providing a new ...
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Mesenchymal stem cell transplantation as an effective treatment strategy for ischemic stroke in Asia: a meta-analysis of controlled trials
... published literature is still not sufficient to perform reliable statistical analysis. Sources of MSC may also associate with treatment outcomes. Based on our extracted data, autogenous MSCs were associated with ...
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Cell therapy with adipose tissue mesenchymal stem cells improves the quality of the germinal epithelium in swiss mice
... proposals, cell therapy with mesenchymal stem cells, regardless of their origin (bone marrow, umbilical cord or adipose tissue), has shown positive effects on the recovery of structural damage of the ...
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Probing Trapped Extracellular Vesicles by Surface-Enhanced Raman Spectroscopy
... growing cell cultures. Live-cell images were obtained with an EVOS FLoid Cell Imaging Station (Thermo Fisher ...in cell culture media, the confluency of cells was measured to be > ...
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Current status and potential challenges of mesenchymal stem cell-based therapy for malignant gliomas
... different cell surface markers, such as desmin, vascular endothelial (VE)-cadherin, α-smooth muscle actin (α-SMA), nestin, and nerval/glial antigen (NG2) (Table 1) ...multiple cell lines, such as bone [26], ...
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