mesenchymal stem cell fate
Mesenchymal stem cell fate : applying biomaterials for control of stem cell behavior
... improve cell growth and differentiation in vitro (Murphy and Atala, ...of stem cells. Stem cells are well placed to underpin TE due to their unique characteristics of self-renewal and ...of ...
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Mesenchymal stem cell fate is regulated by the composition and mechanical properties of Collagen Glycosaminoglycan scaffolds
... adult stem cell ...as stem cell differentiation whereby matrix rigidity and actomyosin contractility modulated MSC differentiation (Discher et ...influencing cell behaviour and overall ...
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Mesenchymal stem cell fate following non viral gene transfection strongly depends on the choice of delivery vector
... Traditionally, viral vectors such as retrovirus, lentivirus and adenovirus, have been used for the delivery of genes into cells via a process known as transduction [10,12,13]. Although they offer high transduction ...
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Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging
... tendon stem cell niche in the extracellular matrix (21, ...on cell adherence in vivo, Fmod-deficient (Fmod-KO) mice were generated by CRISPR/Cas-mediated genome engineering with Exon 2 as the target ...
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The extracellular microscape governs mesenchymal stem cell fate
... Tissue engineering is now faced with the challenge of how to most accurately and reliably reproduce and modulate each individual physical factor and then com- bine them into one cohesive environment. The enormity of this ...
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The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate
... the orientation of the nucleus. Arsenovic et al. [16] uti- lized a fluorescence resonance energy transfer (FRET)- based sensor to demonstrate that the LINC complex, specifically nesprin-2 giant (nesprin-2G), can sense ...
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Effects of matrix metalloproteinases on the fate of mesenchymal stem cells
... Although there is no direct connection between se- creted proteins and MMP activity, it is clear that MMPs play an important regulatory role during differentiation of MSCs into chondrocytes. The role of MMP-13 during ...
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Nanostructured scaffold as a determinant of stem cell fate
... the cell surface area, it is a perfect platform for the cells to organize and spread around the nanofibers with numerous focal adhesion points ...tendon stem/progenitor cells to tendons using electrospun ...
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Multidimensional nanomaterials for the control of stem cell fate
... on cell surface receptors for stem cell ...in mesenchymal stem cells, result- ing in a ...specific cell membrane receptors: platelet- derived growth factor receptor α (PDGFRα) ...
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The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy
... dynamic fate of implanted allogeneic ASCs, includ- ing being eliminated by recipients, being maintained in the stem cell state, or differentiating into various cell types? It will be helpful ...
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Modulating the biochemical and biophysical culture environment to enhance osteogenic differentiation and maturation of human pluripotent stem cell-derived mesenchymal progenitors
... designing stem cell culture environments in micro-bioreactor formats) ...of cell and culture materials ...on cell survival, growth, and dif- ferentiated phenotype ...in stem cell ...
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Stem cell fate in cultured human epidermis
... dermis, including the basem ent m embrane, on stem cell position, using the relative levels of integrin expression as a marker of stem cell patches. Integrin expression [r] ...
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The role of mitochondria in stem cell fate and aging
... mediating stem cell activity has been largely neglected owing to the low abundance of mitochondria in many types of stem cells, and their widely recognized dependence on glycolysis for energy ...
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Molecular mechanisms controlling asymmetric and symmetric self-renewal of cancer stem cells
... underlying cell proliferation, survivals, and self- renewal cell division (Al-Hajj & Clarke 2004; Reya et ...self-renewal cell division (Luo et ...various cell types revealed that ...
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Dental follicle mesenchymal stem cell administration ameliorates muscle weakness in MuSK-immunized mice
... dendritic cell functions have effectively inhibited EAMG development in experimental models [31, ...dendritic cell phagocytosis func- tions are known to be resistant to EAMG induction ...dendritic ...
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Mesenchymal stem cell transplantation as an effective treatment strategy for ischemic stroke in Asia: a meta-analysis of controlled trials
... ered a promising treatment for IS as it may reduce injury and promote rehabilitation after stroke. Mesenchymal stem cells (MSCs) are derived from mesoderm and have the capacity of regeneration and ...
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Stem cells labeled with superparamagnetic iron oxide nanoparticles in a preclinical model of cerebral ischemia: a systematic review with meta-analysis
... In addition the positive cells homing reached the injured organ viability by Prussian blue staining, three studies [14,18,26] assessed expressions by using the green fluorescent protein (GFP) and in all cases the sites ...
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Sex Steroids and Stem Cell Function
... MSCs are novel therapeutic agents for organ protection, and estrogens may en- hance the protective function of MSCs by increasing or decreasing cytokine and growth factor production in these cells (47). Our previous ...
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From genes to plants via meristems
... questions. Stem cell number in the SAM is controlled by an autoregulatory loop between the putative ligand CLAVATA3 (CLV3) signalling through the CLV1 receptor kinase to the homeodomain protein WUSCHEL ...
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Mesenchymal stem cell-based therapy in kidney transplantation
... for cell-based therapies for GVHD [4] and kidney trans- plantation [22, 27], and in many other clinical ...various cell types and tissues; (3) secretion of bioactive molecules; (4) immunomodulation by their ...
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