Metabolizing enzyme
Effects of Processing on Antioxidant Capacity and Metabolizing Enzyme Inhibition of Tiger Nut Tubers
... There are a number of products on the market currently that incorporate tubers, yet tiger nut (tuber) is an underutilized crop that may have functional proper- ties. The effects of processing on antioxidant content, ...
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Cyclophosphamide metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node positive breast cancer: a retrospective cohort study
... amide-metabolizing enzyme polymorphisms that were associated with functional effects on enzyme expression, levels or activity, then excluding those in which the expected prevalence of the combination ...
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Original Article Genetic analysis of drug-metabolizing enzyme CYP3A5 polymorphisms in Tibetans in China
... important metabolizing enzyme sys- tem in humans, and play a central part of the metabolism of many compounds, specially the biotransformation of clinical medicine [1, ...three enzyme families, among ...
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Original Article Genetic polymorphisms and phenotypic analysis of drug-metabolizing enzyme CYP2C19 in a Li Chinese population
... CYP2C19 enzyme results in broad inter-individual variability in response to certain clinical drugs, while little is known about the genetic variation of CYP2C19 in Li Chinese popula- ...
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Drug metabolizing enzyme activities versus genetic variances for drug of clinical pharmacogenomic relevance
... this enzyme has one of the highest numbers of genetic polymorphisms, with over 100 variants described to date ...less enzyme activity, the IM subjects had between 10 and 100 times less activity, and UM had ...
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Original Article Genetic polymorphism analysis of CYP2J2 drug-metabolizing enzyme in a Chinese Zhuang population
... We directly used DNA sequencing to investigate the promoter, exons and surrounding introns, and 3’-untranslated region of the CYP2J2 gene in 100 unrelated healthy Zhuang individuals and [r] ...
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Original Article Genetic polymorphisms of the drug-metabolizing enzyme cytochrome P450 2A6 in a Tibetan Chinese population
... Abstract: Detection of CYP2A6 variant alleles, and knowledge about their allelic frequency in Tibetan ethnic groups, is important to establish the clinical relevance of screening for these polymorphisms to optimize ...
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Original Article Polymorphisms of drug-metabolizing enzyme CYP2J2 in Wa population from Yunnan Province of China
... Cytochrome P450 superfamily (CYP) is a large and diverse group of membrane-associated enzymes that can catalyze many various reactions, such as oxidation, peroxidation, hydroxylation and epoxidation, to metabolize both ...
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A non lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice
... Data on the effects of Plasmodium infection on drug metabolizing enzymes (DMEs) are sparse. However, the evidence collectively suggests that Plasmodium infection has a significant effect on the regulation of the ...
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Clinically relevant genetic variants of drug-metabolizing enzyme and transporter genes detected in Thai children and adolescents with autism spectrum disorder
... Abstract: Single-nucleotide polymorphisms (SNPs) among drug-metabolizing enzymes and transporters (DMETs) influence the pharmacokinetic profile of drugs and exhibit intra- and interethnic variations in drug ...
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Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery
... Table 3: Analysis of SNPs in GSTP1 in all subjects (significant at p < 0.05) and in 4 subgroups defined by NETT based on upper lobe predominant emphysema on chest CT (upper lobe pr[r] ...
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EFFECTS OF CURCUMIN ANALOGUE, 2, 6-BIS (2, 5-DIMETHOXYBENZYLIDENE) CYCLOHEXANONE (BDMC33) ON THE ACTIVITIES OF DRUG-METABOLIZING ENZYMES IN CULTURED CACO-2 CELL MODEL
... At the time intervals of 1, 2, 3 and 4 hours, attached Caco-2 cell monolayers in 6-well plate were removed from the incubator and placed on ice cold water for 10 min. The media in all wells were discarded and rinsed ...
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Original Article Effects of suberoylanilide hydroxamic acid on rat cytochrome P450 enzyme activities
... CYP2C19 enzyme of rats, induction of drug metabolizing enzyme reduces the efficacy of drug; it could show that the SAHA inhibit the activity of CYP1A2, and may slight inhibit the activity of CYP2D6 ...
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A REVIEW ON GENETIC POLYMORPHISM OF CYTOCHROME P-450 2C19 AND ITS CLINICAL VALIDITY
... drug-metabolizing enzyme) and the collection of blood and/or urine, in order to determine some measure of the enzyme’s functional activity, followed by measurement of the metabolic ratio (MR, defined as the ...
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“Scientific Aspects of the Therapeutic Use of Andrographis paniculata (kalmegh): A Review” by Sonia Mol Joseph, India.
... was reported by Shukla et al. in 1992 54 . The efficacy of andrographolide and neoandrographolide against ethanol and acetaminophen induced liver damage was comparable to silymarin 55 . However previous studies were ...
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In vitro Metabolism of Risperidone on Isolated Microsomes of Rat Liver: Metabolite Identification and Profiling by RP-HPLC and LC-MS Techniques
... An oral formulation of RIS has been approved in 1993 by US FDA for the treat- ment of schizophrenia. RIS is an atypical antipsychotic drug reported to improve both the positive and negative symptoms of schizophrenia. Its ...
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Gut instincts: CYP3A4 and intestinal drug metabolism
... drug-metabolizing enzyme CYP3A4 is often implicated in this process, resulting, in some cases, in systemic exposures of less than 15% of the administered ...
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Effect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes
... The effects of honokiol and prototypical inducers on CYP1A2, CYP2B6, and CYP3A4 enzyme activities were evaluated in three human hepatocyte lines (Table 3). CYP1A2-catalyzed phenacetin O-deethylase activity was ...
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CHANGES IN HEPATIC DRUG METABOLIZING ENZYMES DURING PREGNANCY
... drug metabolizing enzymes is altered during ...drug metabolizing enzymes through transcriptional mechanisms leading to altered enzyme ...on enzyme expression, pharmacokinetic changes can be ...
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The Relationship between Glutamate and Multiple Sclerosis
... can be used as an enzyme-electrochemical biosensor for detecting compounds such as glucose, cholesterol, and glutamate (97). Another method for measuring the relative concentration of neurotransmitters inside the ...
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