Metallo-β-lactamases
A study of Biofilm formation & Metallo-β-Lactamases in Pseudomonas aeruginosa in a tertiary care rural hospital
... the Metallo-β-Lactamases genes and their spread among bacterial pathogens is a matter of concern with regard to the future of antimicrobial ...of Metallo-β-Lactamases among ...
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Phenotypic and genotypic detection of metallo β lactamases in A baumanii isolates obtained from clinical samples in Shahrekord, southwest Iran
... Results: A total of 100 A. baumanii were isolated from 250 clinical samples between June 2013 and June 2014. Then, the isolates were identified by biochemical tests, and MBL screening was conducted by the phenotypic ...
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Association Between Metallo-β-lactamases and Integrons with Multi-Drug Resistance in Pseudomonas aeruginosa Isolates
... acquire and integrate circular gene cassettes [4]. The gene cassettes in the variable segment of in- tegrons, contain an antibiotic resistance gene and a recombination site (59-bp, also called attC), which is recognized ...
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Identification and preliminary characterization of novel B3 type metallo β lactamases
... Antibiotic resistance has emerged as a major global threat to human health. Among the strategies em- ployed by pathogens to acquire resistance the use of metallo-β-lactamases (MBLs), a family of ...
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Detection of Pseudomonas aeruginosa Producing Metallo β-Lactamases (VIM, SME, AIM) in the Clinical Isolates of Intensive Care Units of Al-Zahra Hospital in Isfahan, Iran
... most β- lactams ...of β –lactamases dominating no significant carbapenemase activity (AmpCs), or to expression of really carbapenemases ...the metallo-β-lactamases (MBLs such as ...
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Bacteriological Profile and Detection of ESBL, Amp C and Metallo-β-Lactamases in Type 2 Diabetes Patients with Urinary Tract Infection
... AND METALLO-β- LACTAMASES IN TYPE 2 DIABETES PATIENTS WITH URINARY TRACT INFECTION” is the bonafide work done by me at the Department of Microbiology, ...
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Metallo β Lactamases: A Major Threat to Human Health
... Antibiotic resistance is one of the most significant challenges facing global healthcare. Since the 1940s, antibiotics have been used to fight infections, initially with penicillin and subsequently with various ...
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Unusual metallo β lactamases may constitute a new subgroup in this family of enzymes
... of β -lactamases, enzymes capable of breaking down the most widely used antibio- tics, and the β -lactams ...of β -lactamases are distinguished, the Serine- β -lactamases ...
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The Mechanisms of Catalysis by Metallo β Lactamases
... B β-lactamases or metallo-β-lactamases (MBLs) require zinc ions to catalyse the hydrolysis of β-lactam antibiotics such as penicillins, cephalosporins, carbapenems, and ...the ...
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Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data
... Second, the gene G04 (in this study named MYO-1) in family 4 was located, together with a tetracycline resist- ance gene, on a plasmid in the genome of the opportun- istic pathogen M. odoratimimus strain PR63039. This ...
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Detection of Different Types of Metallo-β-Lactamases among Pseudomonas aeruginosa Isolates Obtained from Intensive Care Unit Patients
... 22. Kang CI, Kim SH, Kim HB, Park SW, Choe YJ, Oh MD, Kim EC, Choe KW. Pseudomonas aeruginosa bacteremia: risk factors for mortality and influence of delayed receipt of effective antimicrobial therapy on clinical outcome. ...
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Characterisation and directed evolution of novel metallo-β-lactamases - spr-1 and aim-1
... (47). β-Lactams mimic the D-alanine-D-alanine unit and irreversibly inhibit the PBP and in so doing they compromise the integrity of the cell wall (Figure ...
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Sensitive EDTA Based Microbiological Assays for Detection of Metallo β Lactamases in Nonfermentative Gram Negative Bacteria
... The worldwide spread of metallo-  -lactamase (MBL)-producing gram-negative bacilli represents a great concern nowadays. Sensitive assays for their specific detection are increasingly demanded to aid infection ...
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Prevalence of metallo-β-lactamases in carbapenem resistant acinetobacter baumannii isolated from tracheal secretions
... Though, β-lactams have been broadly used as the backbone for treating several bacterial infections, carbapenems are the last line of drug but since 2000, carbapenem resistance due to acquired carbapenemases has ...
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Detection of Pseudomonas aeruginosa Producing Metallo β Lactamases in a Large Centralized Laboratory
... producing metallo-  -lactamases (MBLs) was first reported from Japan in 1991 (43) and since then has been described from various parts of the world, in- cluding Asia (19, 44, 48), Europe (16, 21, 29, 32), ...
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Probing the interaction of Aspergillomarasmine A (AMA) with metallo-β-lactamases NDM-1, VIM-2, and IMP-7
... consistent with previously published crystal structures. 24,49,53 The 1 H NMR spectra did not show evidence of metal abstraction with concentrations as high as five molar equivalents of L-captopril (Figure 7). ...
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Computational analysis of pathogen borne metallo β lactamases reveals discriminating structural features between B1 types
... The variety, structure, function and medical signifi- cance of these proteins have been the focus of much research in the past, and they may be classified both molecularly and functionally. Traditionally, MBL pro- teins ...
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Evaluation of a New Etest for Detecting Metallo β Lactamases in Routine Clinical Testing
... The introduction of carbapenems into clinical practice rep- resented a great advance for the treatment of serious bacterial infections caused by -lactam-resistant bacteria (17). Due to their broad spectrum of activity ...
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Detection of metallo β lactamases encoding genes among clinical isolates of Pseudomonas aeruginosa in a tertiary care hospital, Kathmandu, Nepal
... Among various mechanism of resistance for carbape- nem in P. aeruginosa, production of MBLs is of particular concern because of their rapid spread, potent carbap- enemase activity, resistance to β-lactamase ...
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PCR Typing of Genetic Determinants for Metallo β Lactamases and Integrases Carried by Gram Negative Bacteria Isolated in Japan, with Focus on the Class 3 Integron
... Since metall--lactamases (MBLs) can hydrolyze a very wide range of broad-spectrum -lactams, MBL-producing gram-negative bacteria usually demonstrate consistent resis- tance to a variety of broad-spectrum ...
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