MFG-E8
MFG E8–mediated uptake of apoptotic cells by APCs links the pro and antiinflammatory activities of GM CSF
... GM-CSF–induced MFG-E8 expression may be an additional mechanism of immune suppression in the tumor ...of MFG-E8 by immunohistochemistry (Supplemental Figure 6 and data not ...
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MFG-E8 and HMGB1 Are Involved in the Mechanism Underlying Alcohol-Induced Impairment of Macrophage Efferocytosis
... macrophage MFG-E8 gene expression and efferocytosis differs from that of chronic alcohol ...both MFG- E8 and HMGB1, two molecules that have opposite effects on macrophage efferocy- ...
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Autoimmunity in MFG E8–deficient mice is associated with altered trafficking and enhanced cross presentation of apoptotic cell antigens
... of MFG-E8 in facilitating the digestion of apoptotic cell–associated ...with MFG-E8 are swiftly phagocytosed by ...in MFG-E8–deficient mice, phagocytosis of intact apoptotic cell ...
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MFG-E8 mediates arterial aging by promoting the proinflammatory phenotype of vascular smooth muscle cells
... locate MFG-E8 and phosphorylated NF-κB p65 in the mouse and human arteries, the paraffinized sections were deparaffinized, permeabilized with ...against MFG-E8 (1:200, R&D Systems) and ...
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Fractalkine-Induced MFG-E8 Leads to Enhanced Apoptotic Cell Clearance by Macrophages
... of MFG-E8, which is uregulated by CX 3 CL1, abrogated the prophagocytic effect of CX 3 ...of MFG-E8 and phagocytosis of apoptotic cells, we believe that this chemokine plays a crucial role ...
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The impact of MFG-E8 in chronic pancreatitis: potential for future immunotherapy?
... that MFG-E8 correlates significantly with the presence of pancreatic pain in CP ...a) MFG-E8 expression may be induced by a yet unknown common factor that likewise induces pain in CP patients, ...
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Milk Fat Globule-Epidermal Growth Factor 8 Is Decreased in Intestinal Epithelium of Ulcerative Colitis Patients and Thereby Causes Increased Apoptosis and Impaired Wound Healing
... mouse MFG-E8 administration attenu- ated inflammatory mediator secretion of macro phages induced by lipopolysac- charide (LPS) in a NF-κB–dependent manner ...whether MFG-E8 is involved in the ...
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The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid β toxicity
... that MFG-E8 has neuroprotective effects against oAβ tox- icity by enhancing microglial phagocytic activity and exerting anti-oxidant ...effects. MFG-E8 was initially described as a mouse ...
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Milk Fat Globule-EGF Factor 8 Is a Critical Protein for Healing of Dextran Sodium Sulfate-Induced Acute Colitis in Mice
... with MFG-E8 rescued MFG-E8-deficient mice from DSS- induced colitis and ameliorated DSS-in- duced colitis in WT ...recombinant MFG-E8 (20 μg/kg) twice a day for 9 d that was ...
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Milk fat globule epidermal growth factor factor 8 derived peptide attenuates organ injury and improves survival in sepsis
... and by reducing the expression of pro-inflammatory mediators, such as inducible nitric oxide synthase and interferon-gamma and matrix metalloproteinase-9 [48, 49]. Similar to our findings, a recent study has also re- ...
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Milk fat globule–EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium
... Localization of MFG-E8 in the murine small intestine. Double immuno- fluorescent staining of normal mouse small intestine using antibod- ies against MFG-E8 and F4/80. Arrows in the merge panel ...
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The amelioration of phagocytic ability in microglial cells by curcumin through the inhibition of EMF-induced pro-inflammatory responses
... of MFG-E8 produc- tion during sepsis is primarily dependent on activation of the LPS-CD14-TLR4 pathway, and that phagocytosis of apoptotic cells is associated with the TLR4-MFG-E8 path- way ...
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Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction
... or MFG-E8 KO mice, livers of CCl 4 -injected mice, and spleens of WT mice were ...anti-human MFG-E8 antibody (1:200) (53) and rabbit anti-αSMA antibody (1:200, EPR5368; Epitomics) and ...
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NCoR1 Mediates Papillomavirus E8^E2C Transcriptional Repression
... in E8 E2C regulation of the ...in E8 E2C-mediated repression of the LCR, we examined next whether cellular proteins that are implicated in LCR repression by full-length E2 might also be engaged by E8 ...
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Multicolor Flag Game (MFG) as an alternative learning for adaptive students
... The data collection of the present study includes observation, documentation, and questionnaire. The instruments used include an evaluation sheet, student skills checklist and questionnaire for each student. Evaluation ...
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Heterotic standard model moduli
... Moduli K¨ahler Number 3 Complex structure 3 Vector Bundle visible E8 19 Vector Bundle hidden E8 5 Table 1: Moduli fields in “A Heterotic Standard Model” 2 Preliminaries In our approach[r] ...
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The E8 Domain Confers a Novel Long-Distance Transcriptional Repression Activity on the E8^E2C Protein of High-Risk Human Papillomavirus Type 31
... Previous analyses provided evidence that repression by E2 and N-terminally truncated E2 proteins (comparable to HPV31 E8ˆE2C d3-12) of the P97 promoter (and its equiva- lents from other HPV types) is mainly due to ...
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7% Hypertonic Saline in Acute Bronchiolitis: A Randomized Controlled Trial
... Our primary hy- pothesis was that the higher concentra- tion of saline (7% HS) with epinephrine administered in the ED would confer a greater and more sustained decrease in bronchiolitis[r] ...
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Lignes directrices de pratique clinique 2018 de Diabète Canada
... Chez les adultes atteints de diabète de type 2 et de MCV clinique qui n’atteignent pas leur cible de la glycémie malgré la prise d’un antihyperglycémiant, il faut ajouter un antihyperg[r] ...
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Loops embedded in generalized Cayley algebras of dimension 2r,r≥2
... If we separate the sign coefficients or structure constants zij of the entries of M3 into another matrix Z3 E8 Figure 2.2a, then the resulting matrix S3 E8 can be seen to be the Cayley t[r] ...
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