MHC class I
The MHC class I–like Fc receptor promotes humorally mediated autoimmune disease
... The MHC class I family–like Fc receptor, FcRn, is normally responsible for extending the life span of serum IgG Ab’s, but whether this molecule contributes to autoimmune pathogenesis remains ...
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MHC class I multimers
... A fusion protein containing the extracellular domains of a MHC class I heavy chain together with a 13-amino acid C- terminal tag (that allows site-specific biotinylation), is expressed in E.coli. ...
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Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction
... Allogeneic MHC class I may be recognized by recipient T cells as an intact molecule on the surface of the antigen-presenting cell (APC) (direct recognition) or may be processed and presented as ...
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In vitro analysis of a primary, major histocompatibility complex (MHC)-restricted, cytotoxic T-lymphocyte response to avian leukosis virus (ALV), using target cells expressing MHC class I cDNA inserted into a recombinant ALV vector.
... of MHC-restricted, CD8 1 CTLs in ALV ...serting MHC class I genes via a retrovirus vector that ex- pressed the necessary viral ...BFIV class I MHC genes to function in CTL ...
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Immunogenicity of Peptides Bound to MHC Class I Molecules Depends on the MHC-Peptide Complex Stability
... To study the relation between dissociation of peptides bound to MHC class I molecules and their ability to induce a CTL response, we used nine peptides derived from HBV[r] ...
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Downregulation of MHC class I molecules by human cytomegalovirus-encoded US2 and US11
... different MHC class I locus ...the class I heavy chains that are important for binding to US11, or that determine their sensitivity to US11-mediated dislocation and degradation have not ...
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MHC class I–associated peptides derive from selective regions of the human genome
... The goals of our study were to assess the extent of MAP generation from the entire set of protein-coding genes and to determine whether specific features influence the ability of discrete genes to generate MAPs. We used ...
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Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses
... anti-MHC class I mAb HC10 (IgG1), anti-MHC class II mAb MEM-136 (IgG1), anti-CD81 mAb M38 (IgG1), anti-NTAL mAb NAP-07 (IgG1), anti-Lck mAb Lck-01 (IgG1) and anti-CD45 mAb MEM-55 (IgG1) ...
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DNMT1 regulates expression of MHC class I in post-mitotic neurons
... anti-mouse MHC class I antibody (1:200, clone ErHr52, BMA Biomedicals, Augst, Switzerland), mouse monoclonal IgG1 anti-β-III-tubulin antibody (1:50, clone TUJ-1, Santa Cruz, Texas, USA), and rabbit ...
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Evidence for successive peptide binding and quality control stages during MHC class I assembly
... glucosidase I and II (Figure ...human MHC class I molecules, as seen in the three-dimensional structure [8], these results suggest that, in addition to the glycan-dependent aspect of ...
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Evolution of MHC class I genes in the European badger (Meles meles)
... in MHC genes; however, mammalian MHC class I genes tend to cluster by ...of MHC class I genes have been biased toward a few particular taxa and model ...of MHC ...
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Transcription variants of SLA 7, a swine non classical MHC class I gene
... of MHC class I molecules contri- butes to their expression on the cell surface [20] and that mutations of cysteine residues in the cytoplasmic tail of MHC class Ia molecules modify ...
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Tapasin enhances MHC class I peptide presentation according to peptide half life
... HC class I molecules may be the ultimate proteomic microarray ...cell, MHC class I molecules provide a readout of the expression level of up to 10,000 proteins ...tumorigenesis. ...
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Indirect T cell allorecognition of donor MHC class I alloantigens
... towards MHC class II derived allopeptides (Benichou at ai 1992), though the in vivo influence of indirect recognition was not ...synthetic class II allopeptides to indicate that indirect recognition ...
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Virus-Like Particles as Carriers for T-Cell Epitopes: Limited Inhibition of T-Cell Priming by Carrier-Specific Antibodies
... (LCMV)-derived MHC class I-restricted pep- tide p33 (23) or MHC class II-restricted peptide p13 ...(MHC class I) and p13 (MHC class II) in vitro and ...
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Mouse Norovirus Infection Reduces the Surface Expression of Major Histocompatibility Complex Class I Proteins and Inhibits CD8+ T Cell Recognition and Activation
... in MHC class I surface expression in cells that were infected with MNV (NS5 positive) from that in mock- infected cells ...of MHC class I expression was evaluated by measuring ...
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The Missing Link in Epstein-Barr Virus Immune Evasion: the BDLF3 Gene Induces Ubiquitination and Downregulation of Major Histocompatibility Complex Class I (MHC-I) and MHC-II
... surface MHC class I and class II are functional in protecting BDLF3-ex- pressing cells against recognition by both CD8 ⫹ and CD4 ⫹ T ...surface MHC molecules more dra- matically than ...
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Evidence for the involvement of gamma delta T cells in the immune response in Rasmussen encephalitis
... The observation of polarized granzyme B-containing CD8 + T cells in brain parenchyma in close proximity to neurons and astrocytes has pointed to a role for major histocompatibility complex (MHC) class ...
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The Major Histocompatibility Complex Class I Genes of Zebrafish.
... nonclassical MHC class I molecules can carry out functions such as specialized antigen presentation, IgG transport, or immunoregulation via interaction with NK-cell receptors (Watanabe et ...
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Novel epitope based peptides for vaccine against SARS-CoV-2 virus: immunoinformatics with docking approach
... Results: A total of fourteen linear B-cell epitopes where GQSKRVDFC displayed the highest antigenicity-score and sixteen highly antigenic 100% conserved T-cell epitopes including the most potential vaccine candidates ...
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