MHC class I expression
Mouse Norovirus Infection Reduces the Surface Expression of Major Histocompatibility Complex Class I Proteins and Inhibits CD8+ T Cell Recognition and Activation
... in MHC class I surface expression in cells that were infected with MNV (NS5 positive) from that in mock- infected cells ...of MHC class I expression was evaluated ...
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Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis.
... In contrast to decreased MHC class I expression, the expression of the JHMV S protein on the cell surface of infected J774.1 cells was clearly detectable at 8 h p.i.. and increased with [r] ...
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The Major Histocompatibility Complex Class I Genes of Zebrafish.
... nonclassical MHC class I molecules can carry out functions such as specialized antigen presentation, IgG transport, or immunoregulation via interaction with NK-cell receptors (Watanabe et ...
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Altered Expression of TAP-1 and Major Histocompatibility Complex Class I in Laryngeal Papillomatosis: Correlation of TAP-1 with Disease
... and MHC-I are co-down-regulated in laryngeal pap- illoma ...reduced MHC-I. Figure 1 depicts the contrast in expression of TAP-1 and MHC-I between cryopreserved normal and ...
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Driving adenovirus type 12-transformed BALB/c mouse cells to express high levels of class I major histocompatibility complex proteins enhances, rather than abrogates, their tumorigenicity.
... Thus, synergism between nonspecific effector cell function, class I MHC expression, and interleukin production is a thymus-dependent mechanism that could contribute to the differences in[r] ...
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Vesicular stomatitis virus infection of the central nervous system activates both innate and acquired immunity.
... p.i., expression of iNOS was detected in microglial cells in the ...iNOS expression coincided with decreased virus ...of MHC expression (21). In addition, both MHC class I ...
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Expression, purification and characterization of ricin vectors used for exogenous antigen delivery into the MHC class I presentation pathway
... The pUTA vector (12) containing the RTA-peptide fusion sequence (1) was transformed into competent E. coli JM101. A single transformant was used to inoculate 100 ml of 2YT medium (17 g/l bactotryptone, 10 g/l yeast ...
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Characterization of a Murine Cytomegalovirus Class I Major Histocompatibility Complex (MHC) Homolog: Comparison to MHC Molecules and to the Human Cytomegalovirus MHC Homolog
... m144 expression plasmid was cotransfected with either a human b2m (hb2m) (13) expression vector or the previously described mb2m expression vector into CHO cells by a Lipofectin procedure (GIBCO ...
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Posttranscriptional Inhibition of Class I Major Histocompatibility Complex Presentation on Hepatocytes and Lymphoid Cells in Chronic Woodchuck Hepatitis Virus Infection
... of class I heterodimers and the availability of processed viral peptides for their ...of class I complexes on liver cells irrespective of the phase of ...HPM class I heavy- chain ...
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Potent Immunosuppressive Activities of Cytomegalovirus- Encoded Interleukin-10
... surface expression of both major histocompatibility complex (MHC) class I and class II molecules, while conversely increasing expression of the nonclassical MHC allele ...
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Prevalent expression of the immunostimulatory MHC class I chain–related molecule is counteracted by shedding in prostate cancer
... Ectopic expression of RAE-1 or H60 on tumor cells resulted in potent tumor rejection by NK cells in syngeneic mice (27), which suggests a potential role for NKG2D-mediated activation of cytolytic effector cells in ...
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A Novel Bat Herpesvirus Encodes Homologues of Major Histocompatibility Complex Classes I and II, C-Type Lectin, and a Unique Family of Immune-Related Genes
... The term C-type lectin was originally introduced to distinguish between Ca 2⫹ -dependent and Ca 2⫹ -independent carbohydrate- binding lectins, but the C-type lectin superfamily now includes a large number of proteins ...
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The expression of heat shock protein hsp27 and a complexed 22-kilodalton protein is inversely correlated with oncogenicity of adenovirus-transformed cells.
... The correlation of oncogenicity with the absence of the 22- and 27-kDa proteins is even better than the correlation of oncogenicity with the lack of expression of the class I MHC antigen[r] ...
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Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses
... (type I) and a short 28 kDa form (type II) resulting from an alternative splicing process of the pro- duct of the encoding gene ...differential expression can lead to distinct functional outcomes ...
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Expression of class I and class II major histocompatibility antigens on human hepatocellular carcinoma
... express class I MHC antigens and among them, three poorly differentiated human HCC cell lines also express class II MHC ...the class I and class II MHC ...
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Structural and Functional Dissection of Human Cytomegalovirus US3 in Binding Major Histocompatibility Complex Class I Molecules
... type I transmembrane proteins has also been characterized as an ER retention signal (20, ...to MHC class I molecules, thereby interfering with their cell surface ...
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DNMT1 regulates expression of MHC class I in post-mitotic neurons
... 5-hydroxymethylcytosine (5hmC), which was discovered simultaneously in mouse ESCs [42] and in adult mouse cerebellar Purkinje cells [56], the concept of active de- methylation arose. Methylated DNA can be demethy- lated ...
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Varicella-Zoster Virus Productively Infects Mature Dendritic Cells and Alters Their Immune Function
... surface expression of the functionally important immune molecules major histocompatibility complex (MHC) class I, CD80, CD83, and CD86 but did not alter MHC class II ...
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Indirect T cell allorecognition of donor MHC class I alloantigens
... and class I assembly, and that the process was ATP-dependent (Neefjes at ai ...by class I molecules; the transporter is also size selective (Momburg at ai ...to class I ...1992): ...
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Expression of m157, a Murine Cytomegalovirus-Encoded Putative Major Histocompatibility Class I (MHC-I)-Like Protein, Is Independent of Viral Regulation of Host MHC-I
... cells were infected as described for Fig. 1, with MCMV at MOI of 5. Total RNA was isolated at the times indicated after infection, using TRIZOL reagent (Life Technologies) according to the manufacturer’s protocol. The ...
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