MHC CLASS-II
Autoimmunity associated with TGF beta1 deficiency in mice is dependent on MHC class II antigen expression
... of class II anti- gens can be found on committed hematopoietic progenitors, particularly those of the granulocyte-monocyte-erythrocyte and megakaryocyte ...of MHC class II antigens, ...
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Methyldopa blocks MHC class II binding to disease specific antigens in autoimmune diabetes
... Figure 5. Methyldopa treatment specifically blocks DQ8 antigen presentation in recent-onset T1D patients with the DQ8 allele. (A) Diagram of the assay used to monitor specific MHC class II antigen ...
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Tolerance to solid organ transplants through transfer of MHC class II genes
... Animals and protocols used in this study. Massachusetts General Hospital Miniature Swine (3–5 months old) received either allogeneic or syngeneic MHC class II cDNA through transduction of autologous ...
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Towards the simplification of MHC typing protocols: targeting classical MHC class II genes in a passerine, the pied flycatcher Ficedula hypoleuca
... popular MHC-typing protocols, including next-generation sequencing approaches [6], rely on PCR amplification at some ...in MHC originates to a large extent by recombining alleles exchanging particular ...
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Tumor-specific CD4 T cells eradicate myeloma cells genetically deficient in MHC class II display
... Trichostatin A at the indicated concentrations. (B) mRNA expression of the Air-1 gene in MOPC315 or J558 cells treated as in (A), plotted relative to expression in J558 cells treated with 10 nM Trichostatin A (fold ...
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Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses
... with MHC class I and class II have been previously described ...with MHC molecules have been described ...the MHC and CD99 molecules, we investigated whether the CD99-MHC ...
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Susceptibility of amphibians to chytridiomycosis is associated with MHC class II conformation
... the MHC class II in amphibians illustrating peptide-binding ...the MHC peptide-binding ...all MHC-II b1 included in the study is available in the electronic supplementary ...
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Original Article Design of a ProDer f1 vaccine delivered by the MHC class II pathway of antigen presentation and analysis of the effectiveness for specific immunotherapy
... of Ii-Key to antigen or related epitope was capable of enhancing MHC class epitope charging and Th cell activation [18, ...The Ii-Key hybrids are composed of the Ii moiety linked to the ...
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DEK binding to class II MHC Y box sequences is gene and allele specific
... The similarity of the DQA1*0101 Y-box sequence to the HIV-2 DEK-binding site (see Fig. 1) first led us to investi- gate whether DEK in nuclear extracts binds to MHC class II Y-box regulatory elements ...
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Regulatory functions of self restricted MHC class II allopeptide specific Th2 clones in vivo
... We studied T-cell clones generated from grafts of rejecting and tolerant animals and investigated the reg- ulatory function of Th2 clones in vitro and in vivo. To prevent allograft rejection, we treated LEW strain ...
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Inhibition of allorecognition by a human class II MHC–derived peptide through the induction of apoptosis
... the MHC–peptide complex can result in ...soluble class I MHC molecules in the absence of costimulation is associ- ated with the upregulation of Fas-L and induction of apop- ...single-chain MHC ...
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A Novel Bat Herpesvirus Encodes Homologues of Major Histocompatibility Complex Classes I and II, C-Type Lectin, and a Unique Family of Immune-Related Genes
... type II trans- membrane proteins resembling C-type lectins, for which there is accumulating evidence to support crucial roles in the innate im- mune system (36, ...the MHC class II receptor ...
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Proximity ligation assay evaluates IDH1R132H presentation in gliomas
... on MHC by the target cell or an antigen-presenting cell (APC) in the tumor ...an MHC class II–restricted antigen in paraffin-embedded tissue sections from patients with brain ...with ...
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Virus-Like Particles as Carriers for T-Cell Epitopes: Limited Inhibition of T-Cell Priming by Carrier-Specific Antibodies
... (MHC) class I pathway. In general, exogenous antigens reach the MHC class II pathway while only endogenous antigens efficiently fuel the MHC class I pathway (7, ...the ...
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Varicella-Zoster Virus Productively Infects Mature Dendritic Cells and Alters Their Immune Function
... Mature dendritic cells (DCs) are potent antigen-presenting cells essential for initiating successful antiviral immune responses and would therefore serve as an ideal target for viruses seeking to evade or delay the ...
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Expression of class I and class II major histocompatibility antigens on human hepatocellular carcinoma
... express class I MHC antigens and among them, three poorly differentiated human HCC cell lines also express class II MHC ...the class I and class II MHC ...
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Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 3 Inhibits Gamma Interferon and Major Histocompatibility Complex Class II Expression
... of MHC class I is inhibited by KSHV proteins vIRF-1 (23) and K3/K5 (19) by either down- regulation or degradation of MHC I molecules, ...of MHC II presentation by viruses was observed ...
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Adenoviruses Activate Human Dendritic Cells without Polarization toward a T-Helper Type 1-Inducing Subset
... and MHC molecules but does not polarize DC toward a Th1-in- ducing ...surface MHC class II molecules, but the levels of expression of these markers were lower than those obtained by ...
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T Cells Cause Acute Immunopathology and Are Required for Long-Term Survival in Mouse Adenovirus Type 1-Induced Encephalomyelitis
... to pathology vary among these systems. Perforin-deficient mice have been shown to be resistant to acute disease induced by lymphocytic choriomeningitis virus (37), Murray Valley en- cephalitis virus (47), coxsackievirus ...
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Distinct interferon signatures stratify inflammatory and dysimmune myopathies
... type ii iFn γ signature and naM with neither type i nor type ii iFn ...histocompatibility class 2 (MHc-2) and ciita, confirming the induction of the iFn γ ...Furthermore, MHc-2-positive ...
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