MHC I/MHC II
Original Article Comparative immunoprofiling of polymyositis and dermatomyositis muscles
... of MHC-I, MHC-II, MAC and infiltrating ...of MHC-I and MHC-II immunostaining for the diagnosis of ...of MHC-I and MHC-II was both higher ...
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Epitope Based Vaccine Strategy against Sea Anemone Toxins through in Silico Route
... injuries and are potentially lethal [1] and therefore vaccine therapy becomes essential. Recent developments in the field of computational tools enable us to predict epitope from antigenic proteins in a specific way ...
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Differential Incorporation of CD45, CD80 (B7-1), CD86 (B7-2), and Major Histocompatibility Complex Class I and II Molecules into Human Immunodeficiency Virus Type 1 Virions and Microvesicles: Implications for Viral Pathogenesis and Immune Regulation
... incorporated MHC class I (MHC-I), MHC-II, CD80, or ...increased MHC-II expression on T- and B-cell lines, macrophages, and peripheral blood mononclear cells (PBMC) ...
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Protective immunity against acute toxoplasmosis in BALB/c mice induced by a DNA vaccine encoding Toxoplasma gondii elongation factor 1 alpha
... The expression levels of MHC-I and MHC-II molecules as well as the percentages of both CD4+ and CD8+ T cells in mice vaccinated with pVAX-EF-1α were significantly increased p < 0.05, com[r] ...
12
The Capacity of UL49.5 Proteins To Inhibit TAP Is Widely Distributed among Members of the Genus Varicellovirus
... of MHC-I at the cell surface (2, 8, ...of MHC-I (LMH and MJS) and MHC-II (MJS) molecules was assessed by flow cytometry on untransduced cells (graph 2) and ILTV ...
13
Antigen Expression Kinetics and Immune Responses of Mice Immunized with Noninfectious Simian-Human Immunodeficiency Virus DNA
... class I (MHC-I) (6, 30, 33, ...facilitate MHC-I and MHC-II processing path- ways that can support the development of both humoral and cellular immune responses (14, 37, ...
10
Simian immunodeficiency virus induces expression of class II major histocompatibility complex structures on infected target cells in vitro.
... Although MHC-I as well as MHC-II antigens are expressed in greater quantity on the surfaces of chronically SIV-infected cells than on uninfected cells, we were unable to demonstrate the [r] ...
6
The systems biology of MHC class II antigen presentation
... While MHC-I binds peptides in a partially folded state stabilized by chaperones in the ER, this is probably different for MHC-II, as endosomes are not known to contribute to ...of ...
97
COVID-19 Vaccine Candidates by Identification of B and T Cell Multi-Epitopes Against SARS-COV-2
... Effective vaccination is important to contain the pandemic outbreak of SARS-COV-2. Vaccine trials are ongoing but vaccine development can take several months to years. Lots of ongoing research concentrate on SARS-COV-2 ...
12
Targeting gp100 and TRP 2 with a DNA vaccine: incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial
... A DNA vaccine, SCIB1, incorporating two CD8 and two CD4 epitopes from TRP-2/gp100 was evaluated in patients with metastatic melanoma. Each patient received SCIB1 via intramuscular injection with electroporation. The ...
52
Catheptic antigen processing
... by MHC-encoded class I and class II molecules which transport and display them on the cell ...by MHC class I molecules, which can be expressed on nearly all cell ...with MHC ...
257
Lipid-laden partially-activated plasmacytoid and CD4−CD8α+ dendritic cells accumulate in tissues in elderly mice
... of MHC class-I and class-II mole- cules, suggesting an increased capacity for Ag ...type I interferons, which drive the production of other pro- inflammatory cytokines, and the activation and ...
12
Expression of class I and class II major histocompatibility antigens on human hepatocellular carcinoma
... class I MHC antigens and among them, three poorly differentiated human HCC cell lines also express class II MHC ...class I and class II MHC antigens expressed by the human ...
10
Characterization of a Murine Cytomegalovirus Class I Major Histocompatibility Complex (MHC) Homolog: Comparison to MHC Molecules and to the Human Cytomegalovirus MHC Homolog
... with m144. SDS-PAGE analysis of immunoprecipitated pro- tein from cells expressing m144 and mb2m also reveals two bands migrating at 45 and 12 kDa (data not shown). m144- mb2m was purified from transfected cell ...
7
Novel epitope based peptides for vaccine against SARS-CoV-2 virus: immunoinformatics with docking approach
... SARS-CoV-2 S protein computed via Protparam demonstrates that it contained 1255 amino acids (aa) with a molecular weight of 139125.14 kDa. Theoretical isoelectric point (PI) of the subject protein was 5.56. Total number ...
10
The Epigenetic And Immune Landscapes Of HPV+ Tumor Microenvironments
... of MHC-I heavy chain genes, the β2 microglobulin light chain gene, and other components of the antigen-loading apparatus, which includes: TAP1/2, tapasin, ERp57, calreticulin, calnexin, and ERAP1/2 in human ...
216
Varicella-Zoster Virus Productively Infects Mature Dendritic Cells and Alters Their Immune Function
... with MHC molecules but also on the interaction with several other immune molecules in- cluding CD40, CD54, CD80, CD83, and CD86 (23, 28, ...of MHC class I, MHC class II, CD80, CD83, and ...
10
Co-culture of primary human tumor hepatocytes from patients with hepatocellular carcinoma with autologous peripheral blood mononuclear cells: study of their in vitro immunological interactions
... Although, in vitro and in vivo studies have demo- nstrated that hepatoma cells may express high levels of both class I and class II molecules [10-12], little is known about their potential immunogenicity ...
12
Immunogenicity of Peptides Bound to MHC Class I Molecules Depends on the MHC-Peptide Complex Stability
... To study the relation between dissociation of peptides bound to MHC class I molecules and their ability to induce a CTL response, we used nine peptides derived from HBV[r] ...
7
Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways
... (LAD I). Additionally, a second form of leukocyte adhesion deficiency (LAD II) is caused by deficient expression of sialyl Lewis X determinants, the neu- trophil ligands for E- and ...LAD II present ...
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