MicroRNA-130a
MicroRNA 130a Regulates both Hepatitis C Virus and Hepatitis B Virus Replication through a Central Metabolic Pathway
... regulate microRNA 130a (miR-130a) in patient biopsy specimens and in cultured ...miR- 130a target genes. miR-130a and its target genes were overexpressed or were knocked down by use of ...
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MicroRNA-130a alleviates human coronary artery endothelial cell injury and inflammatory responses by targeting PTEN via activating PI3K/Akt/eNOS signaling pathway
... of microRNA-130a (miR-130a) in human coronary artery endothelial cells (HCAECs) injury and inflammatory responses by targeting PTEN through the PI3K/Akt/eNOS signaling ...
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Original Article MicroRNA-130a overexpression promotes proliferation, migration, and phenotypic modulation of vascular smooth muscle cells via enhancing phosphorylation of NF-κB p65
... Conclusions: MicroRNA-130a overexpression might promote the proliferation, migration, and phenotypic modulation of VSMCs via enhancing phosphorylation of NF-κB ...
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Original Article MicroRNA-130a reduces drug resistance in breast cancer
... miR- 130a is related to drug resistance in several cancers, studies on miR-130a of drug resis- tance in breast cancer have not been ...that microRNA-130b targets PTEN to mediate drug resistance and ...
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<p>Silenced Myeloblastosis Protein Suppresses Oral Tongue Squamous Cell Carcinoma via the microRNA-130a/Cylindromatosis Axis</p>
... Figure 2 miR-130a expression is upregulated by MYB and induces cell proliferation, migration and invasion. (A and B) RT-qPCR was conducted to measure miR-130a expression in the OTSCC tissues and ...
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Original Article MicroRNA-130a inhibits cell proliferation, invasion and migration in human breast cancer by targeting the RAB5A
... however still unclear. The aim of this study was therefore a functional analysis of miR-130a in breast cancer, which were shown to be under- represented in miR-130a in other types of can- cer, such as lung ...
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Original Article MicroRNA-130a promotes apoptosis of alveolar epithelia in COPD patients by inhibiting autophagy via the down-regulation of ATG16L expression
... Abstract: Aims: The present study is to investigate the expression of microRNA (miR)-130a in chronic obstructive pulmonary disease (COPD) tissues, as well as its function and potential mechanism. Methods: A ...
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MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation
... miR-130a has recently emerged as a key miRNA that inhibits cancer cell proliferation, invasion and migration by targeting other cellular proteins that promote cell proliferation or have oncogenic potential. For ...
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microRNA-130a is an oncomir suppressing the expression of <em>CRMP4 </em>in gastric cancer
... Abstract: Gastric cancer is one of the most common causes of death worldwide, although its incidence has steadily declined in recent years. There is strong evidence that aberrantly expressed microRNAs (miRNAs) are ...
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microRNA-130a is an oncomir suppressing the expression of <em>CRMP4 </em>in gastric cancer
... roles and molecular mechanisms underlying miR-130a and CRMP4 involvement in the modulation of the malignant behavior of gastric cancer cells are largely unknown. Inter- estingly, we predicted an interaction ...
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Original Article Decreased expression of microRNA-130a correlates with TNF- α in the development of osteoarthritis
... miRNA- 130a, Forward 5’-TTGCGATTCTGTTTTGTGCT-3’ and Reverse 5’-GTGGGGTCCTCAGTGGG-3’; TNF-α, Forward 5’-TCAGCCGAGGTGATACGTAT -3’ and Reverse 5’-CACGATTAGCCTACATACAA- CGC-3’; GAPDH, Forward 5’-ACAGGGGAGGTG- ...
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Knockdown of LncRNA H19 Relieves LPS Induced Damage by Modulating miR 130a in Osteoarthritis
... Materials and Methods: Abundances of H19 and microRNA-130a (miR-130a) in lipopolysaccharide (LPS)-treated C28/I2 cells were measured by reverse-transcription quantitative PCR (RT-qPCR). CCK-8 and ...
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Differences in microRNA expression between melanoma and healthy adjacent skin
... MicroRNA profiling provided by microarray with a subsequent qPCR confirmation identified miR-146a-5p as one of the most upregulated miRs in melanoma as compared withadjacent non-melanoma tissues. An identical ...
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Screening of differentially expressed microRNAs of essential hypertension in Uyghur population
... the microRNA expres- sion in each sample. The microRNA expression of pa- tients in the essential hypertension group was obviously different from that of healthy controls ...
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Identifying MicroRNA Precursors Using Linear Dimensionality Reduction With Explicit Feature Mapping
... the microRNA family, lin-4 and 14, were originally identified in Caenorhabditis elegans as genes that were necessary for temporal regulation of larval development ...discovering microRNA functions and its ...
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The Intestinal Microbiota Interferes with the microRNA Response upon Oral Listeria Infection
... ABSTRACT The intestinal tract is the largest reservoir of microbes in the human body. The intestinal microbiota is thought to be able to modulate alterations of the gut induced by enteropathogens, thereby maintaining ...
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MicroRNA 889 Inhibits Autophagy To Maintain Mycobacterial Survival in Patients with Latent Tuberculosis Infection by Targeting TWEAK
... FIG 1 Increased microRNA-889 (miR-889) levels in patients with latent tuberculosis infection (LTBI). (A) Differentially expressed miRNAs in peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) ...
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Prediction and Analysis of SARS-CoV-2-Targeting microRNA in Human Lung Epithelium
... that microRNA can mediate an intracellular defence mechanism against some RNA ...identify microRNA with predicted binding sites in the SARS-CoV- 2 genome, compare these to their microRNA expression ...
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Characterization and potential role of microRNA in the Chinese dominant malaria mosquito Anopheles sinensis (Diptera: Culicidae) throughout four different life stages
... Results: In total, 164 miRNAs were obtained out of 107.46 million raw sequencing reads. 99 of them identified as known miRNAs, and the remaining 65 miRNAs were considered as novel. By analyzing the read counts of miRNAs ...
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Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663
... the microRNA precursor consists of a highly stable hairpin due to GC base paring; however, novel technologies have been developed to successfully amplify and quantify the mature ...
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