microRNA-181a
MicroRNA-181a is involved in the regulation of human endometrial stromal cell decidualization by inhibiting Krüppel-like factor 12
... on microRNA microarray analysis, L. Su et al. found high miR-181a/c expression on day 15 of gestation, followed by decreased expression on gesta- tional days 26 and 50 in the porcine endometrium dur- ing ...
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Hsa-microRNA-181a is a regulator of a number of cancer genes and a biomarker for endometrial carcinoma in patients: a bioinformatic and clinical study and the therapeutic implication
... Abstract: The aberrant expression of human microRNA-181a-1 (hsa-miR-181a) has been implicated in the pathogenesis of various cancers, serving as an oncogene or a tumor suppressor. However, the role ...
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Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration
... miR-181a-5p mimic promotes facet cartilage degeneration in vivo. Our in vitro studies using FJ OA chondro- cytes treated with miR-181a-5p or miR-4454 mimic or inhibitor suggest that these miRNAs may play a ...
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Original Article MicroRNA-181a is a predictor of poor survival and a prognostic biomarker of chemoresistance in triple negative breast cancer
... [9]. MicroRNA (miRNA) is an abundant class of conservative and small non- coding RNAs which post-transcriptionally regu- late genes expression by inducing the degrada- tion or translational repression of target ...
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Original Article Electro-acupuncture (EA) mediated downregulation of microRNA-181a alleviates spinal cord neuronal apoptosisby inhibition of p38 MAPK pathway
... the microRNA expression changes in SCI-EA group in comparison with the SCI group at 3 dif- ferent time points after EA treatment, and miR- 181a was found significantly down-regulated in SCI-EA ...
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Original Article MicroRNA-181a knockdown protects HepaRG cells from Dichlorvos-induced oxidative stress and apoptosis
... miR- 181a downregulation has a remedy effect on DDVP-induced cell toxicity, while miR-181a overexpression augments the DDVP-induced hepatic cell apoptosis and ROS ...
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Over-expressed microRNA-181a reduces glomerular sclerosis and renal tubular epithelial injury in rats with chronic kidney disease via down-regulation of the TLR/NF-κB pathway by binding to CRY1
... The targeting regulatory relationship between miR-181a and the CRY1 gene was predicted with the bioinformat- ics prediction website http://www.microRNA.org, and a dual luciferase reporter gene assay was carried ...
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MicroRNA-181a suppresses parkin-mediated mitophagy and sensitizes neuroblastoma cells to mitochondrial uncoupler-induced apoptosis
... oxyphenylhydrazone (FCCP) and carbonylcyanide- 3-chlorophenylhydra-zone (CCCP) are mitochondrial uncouplers that are commonly used to induce mitophagy and the PINK1/Parkin pathway [35]. Both chemicals are nonspecific ...
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Piceatannol induced apoptosis through up-regulation of microRNA-181a in melanoma cells
... miR- 181a, via an independent binding site in its 3 ′ -UTR, which reduces its expression, activity and downstream signaling, and our functional experiments validate Bcl-2 as a critical mediator of the ...
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Signatures of miR-181a on the Renal Transcriptome and Blood Pressure
... MicroRNA-181a binds to the 3’ untranslated region of messenger RNA (mRNA) for renin, a rate-limiting enzyme of the renin-angiotensin system. Our objective was to determine whether this molecular interaction ...
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<p>miRNA-181a-5p Enhances the Sensitivity of Cells to Cisplatin in Esophageal Adenocarcinoma by Targeting CBLB</p>
... Ubiquitination is a post-translational modi fi cation, which targets cellular proteins for degradation. 24 CBLB is the sec- ond member of the E3 ubiquitin ligase CBL family and has been revealed to involve in ...
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Original Article MiR-181a regulates the chondrogenic differentiation in pig peripheral blood mesenchymal stem cells
... The freshly cultured pig PB-MCSs appeared spindle shape after the initial 3 days. After the initial 3 days, the PBMSCs changed to typical polymorphic fibroblast-like morphology. After being subcultured every 3 days, the ...
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Silibinin: An Inhibitor of Mir-181a Gene Expression in Sk-Br-3 Breast Cancer Cell Line
... 33. Wei Z, Cui L, Mei Z, Liu M, Zhang D. miR-181a mediates metabolic shift in colon cancer cells via the PTEN/AKT pathway. FEBS letters. 2014; 588(9):1773-9. https://doi.org/10.1016/j.febslet.2014.03.037; ...
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MiR 181a: a potential biomarker of acute muscle wasting following elective high risk cardiothoracic surgery
... been used to demonstrate that findings in more specific microRNAs do not result from general changes in microRNA levels [12,21]. However, miR-16 has recently been shown to be elevated in the plasma of septic pa- ...
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Molecular cloning and expression of bovine nucleoplasmin 2 (NPM2): a maternal effect gene regulated by miR-181a
... conducted using 6-well culture dishes. HeLa cells were passed at least 12 hours prior to all transfection experi- ments. HeLa cells expressing bovine miR-181a were transfected with NPM2 plasmid (1 μg) or pcDNA3.1 ...
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Original Article miR-181a negatively regulates Kras to inhibit the proliferation and migration of cholangiocarcinoma cell line QBC939
... Abstract: Objective: To investigate whether miR-181a can regulate the expression of Kras to affect the proliferation and migration of cholangiocarcinoma cell line QBC939. Methods: QBC939 cells were divided into D ...
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MicroRNA (miRNA) in cancer
... For ex- ample: (i) circulating miRNA are used in breast cancer as biomarkers to examine therapeutic response (https:// clinicaltrials.gov/ct2/show/NCT01722851); (ii) miR-10b is used in G[r] ...
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BCL2 and hsa miR 181a 5p are potential biomarkers associated with papillary thyroid cancer based on bioinformatics analysis
... The miRNA-gene pairs were based on the 12 common deregulated miRNAs and 263 common DEGs. Thus, 35 miRNA-gene pairs were acquired that included 11 common deregulated miRNAs and 20 common DEGs. We con- structed a ...
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MicroRNA-mediated regulation of target genes in several brain regions is correlated to both microRNA-targeting-specific promoter methylation and differential microRNA expression
... expression, microRNA (miRNA) expression and promoter methylation patterns in four regions, the frontal cortex, temporal cortex, pons and cerebellum, of human brain were sourced from the National Center for ...
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MicroRNA-27b, microRNA-101 and microRNA-128 inhibit angiogenesis by down-regulating vascular endothelial growth factor C expression in gastric cancers
... To determine whether miR-27b, miR101, or miR-128 inhibits VEGF-C-induced endothelial cell migration, transwell monolayer permeability assays were used to detect the changes in migration [r] ...
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