microRNA-21
Overexpression of microRNA 21 strengthens stem cell like characteristics in a hepatocellular carcinoma cell line
... that microRNA-21 (miR- 21) is expressed at higher levels in various CSCs than in the corresponding bulk tumor cells and that it influences CSC behavior ...
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MicroRNA-100 and microRNA-21 as markers of survival and chemotherapy response in pancreatic ductal adenocarcinoma UICC stage II
... clinical significance of MDR-1 expression in human PDAC is controversial. Some research groups failed to demonstrate MDR-1 expression in PDAC tissues, whereas other studies showed a common and high MDR-1 expres- sion ...
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High intensity focused ultrasound inhibits melanoma cell migration and metastasis through attenuating microRNA-21- mediated PTEN suppression
... of microRNA-21(miR-21) was down-regulated and PTEN expression was up-regulated in response to HIFU exposure, which was in concomitant with the reduction of AKT ...
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The role of circulating MicroRNA-21 (miR-21) in epithelial ovarian cancer
... Background: The development of a novel biological marker for diagnosis and prognosis prediction of epithelial ovarian cancer (EOC) remains urgent. Current literature shows that microRNA-21 ...
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Diagnostic Potential Of Circulating MicroRNA-21 In Hepatocellular Carcinoma.
... circulating microRNA as a biochemical marker of ...circulating microRNA in hepatocellular ...plasma microRNA-21 level as a biochemical marker for hepatocellular ...circulating ...
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MicroRNA-21 and PDCD4 expression during in vitro oocyte maturation in pigs
... Utilizing miRNA microarray analysis and deep sequen- cing we have previously identified microRNA-21 (MIR21) as an up-regulated miRNA during porcine oocyte in vitro maturation [41]. In mice it has been ...
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Original Article MicroRNA-21 and microRNA-146a identification in stool and its clinical significance in colorectal neoplasms
... of microRNA-21 (miRNA-21) and microRNA-146a (miRNA-146a) were investigated by quantitate real-time polymerase chain reaction (qRT-PCR) from the tissues of colorectal carcinoma (CRC), ...
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Microarc-oxidized titanium surfaces functionalized with microRNA-21-loaded chitosan/hyaluronic acid nanoparticles promote the osteogenic differentiation of human bone marrow mesenchymal stem cells
... Abstract: Dental implants have been widely used for the replacement of missing teeth in the clinic, but further improvements are needed to meet the clinical demands for faster and tighter osseointegration. In this study, ...
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Association between Serum MicroRNA-21 Gene Expression, Carcinoemberyonic Antigen and Clinicopathological Character for Colorectal Cancer
... of microRNA-21 gene expression and to assess their relation to colorectal cancer (CRC) outcome and correlate it with carcinoemberyonic antigen ...serum microRNA-21 levels and clinic ...
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Investigation of MicroRNA-21 Expression Levels in Serum and Stool as a Potential Non-Invasive Biomarker for Diagnosis of Colorectal Cancer
... of microRNA-21 (miR-21), as a potential diagnostic marker, in serum and stool samples from 40 patients with colorectal cancer (CRC) and 40 healthy ...
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Stress dependent cardiac remodeling occurs in the absence of microRNA 21 in mice
... mRNAs. MicroRNA-21 (miR-21) is upregulated in response to cardiac stress, and its inhibition by a cholesterol-modified antagomir has been reported to prevent cardiac hyper- trophy and fibrosis in ...
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microRNA 21 expressions impact on liver fibrosis in biliary atresia patients
... We ascertained 17 liver specimens from BA patients and seven liver samples from abdominal trauma patients as controls. The controls were one male and six females with their mean age during laparotomy of 5.3 ± 4.8 years. ...
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Original Article MicroRNA-21 and microRNA-155 promote the progression of Burkitt’s lymphoma by the PI3K/AKT signaling pathway
... tion of monocytes and macrophages [18-20]. It regulates the development and function of immune cells [21, 22]. Its dysregulation is also related to cancers [18]. MiR-155 is overex- pressed in colorectal cancer and ...
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An innovative “unlocked mechanism” by a double key avenue for one-pot detection of microRNA-21 and microRNA-141
... For the investigation of miR-21 by the traditional qRT-PCR method, we first needed to reverse transcribe miR-21 from the total miRNA extraction into cDNA at 37 °C for 60 min and 95 °C for 5 min (containing ...
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MicroRNA 21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection
... Fusion of the phagosome with lysosomes, to form the phagolysosome is accompanied by acquisition of antibacterial mechanisms including antimicrobial peptides, proteases, an acidified environment, and the production of ...
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MicroRNA-21 as a Potential Biomarker for Colorectal Cancer Diagnosis: A Meta-analysis
... and NLR were 0.71 (95% CI: 0.67–0.74), 0.78 (95% CI: 0.74–0.83), 3.53 (95% CI: 2.35–5.30), and 0.37 (95% CI: 0.27–0.49), respectively, thus indicating prominent advantage in sensitivity and specificity of miR-21 ...
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MicroRNA 21, 204 and 125b Play Potential Roles in Tumorigenesis of Melanoma
... several microRNA (miRNA) profiling studies have been performed on melanoma tissues, but with extremely inconsistency, the diagnostic value of miRNA candidates in melanoma remains under ...
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Original Article Trimetazidine protects against hypoxia-reperfusion-induced cardiomyocyte apoptosis by increasing microRNA-21 expression
... In H/R+TMZ+ miR-21 inhibitor + siPTEN group, H9C2 cells were transfected with 50 nM miR- 21 inhibitors, next, treated with 10 μM TMZ for 48 h, next, treated with 50 nM siPTEN for 18 h and finally subjected ...
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Downregulation of microRNA-21 inhibited radiation-resistance of esophageal squamous cell carcinoma
... RNA isolation and quantitative real-time PCR (qRT-PCR) Total RNAs were isolated from 63 pairs ESCC tumor and adjacent non-tumoral tissues, and ESCC cells with or without irradiation using the Absolutely RNA ™ RT-PCR ...
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Original Article microRNA-21 is a potential indicator for the pathological progression of cervical cancer
... Human cervical adenocarcinoma HeLa cell line (ATCC, Manassas, VA) were cultured in Dulbecco’s modified Eagle’s medium (DMEM, high glucose) supplemented with 10% fetal bovine serum (FBS, Gibco, Carlsbad, CA), and ...
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