Minor histocompatibility antigens
Immunodominant minor histocompatibility antigens expressed by mouse leukemic cells can serve as effective targets for T cell immunotherapy
... Numerous minor histocompatibility antigens (MiHAs) show tissue-specific expression and can induce vigorous T cell responses. They therefore represent attractive targets for leukemia immunotherapy ...
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Lifting a tip of the veil of human minor Histocompatibility antigens.
... Van Eis C, Bakker A, Zwinderman AH, Zwaan FE, van Rood JJ, Goulmy Ε (1990a) Effector mechamsms in GvHD in response to minor Histocompatibility antigens I Absence of correlation with CTLs[r] ...
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HLA class II restricted minor histocompatibility antigens - identification, processing and biology
... as minor histocompatibility antigens (MiHA) 29 ...recognizing antigens with restricted tissue distribution and therefore allows specific targeting of malignant hematopoietic cells without ...
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New strategies in identification and quantification of minor histocompatibility antigens
... Minor histocompatibility antigens (MiHA) are HLA-presented peptides, derived from polymorphic proteins that differ between individuals due to genomic single nucleotide polymorphisms ...
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CD4 Donor Lymphocyte Infusion Can Cause Conversion of Chimerism Without GVHD by Inducing Immune Responses Targeting Minor Histocompatibility Antigens in HLA Class II
... Under non-inflammatory conditions HLA class II is predominantly expressed on hematopoietic cells. Therefore, donor CD4 T-cells after allogeneic stem cell transplantation (alloSCT) may mediate graft-vs.-leukemia ...
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Expanding the immunotherapeutic potential of minor histocompatibility antigens
... Minor histocompatibility antigens (mHAgs) selectively expressed by cells or cell subsets of the hematopoietic system are targets of the T cell–mediated graft-versus-leukemia response that develops ...
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Characterization and recognition of minor histocompatibility antigens
... To molecularly characterize the MiHA that were targeted by the isolated T-cell clones, we applied whole genome association scanning (WGAs) to detect MiHA-encoding single nucleotide polymorphisms (SNPs). T-cell clones ...
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Recognition of minor histocompatibility antigens on lymphocytic and myeloid leukemic cells by cytotoxic T cell clones.
... IL-2-stimulated normal lymphocytes or leukemic cells from HLA-A 1 -positive patients were lysed only by the HA- 3 mH antigen-specific CTL clone (HLA-A I restricted), and IL[r] ...
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Effector mechanisms in Graft-vs-Host Disease in response to minor Histocompatibility antigens. I. Absence of correlation with cytotoxic effector cells.
... To test the possibility that the failure to detect antihost Tc cells shortly after grafting as observed in several patients might reflect a general Tc cell impairment (as a result of inc[r] ...
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Milosevic, Slavoljub (2003): Identification of minor histocompatibility antigens. Dissertation, LMU München: Fakultät für Biologie
... of antigens presented on MHC class II are currently not available, only few antigens recognized by CD4 + T cells have been identified ...the antigens recognized by the CD4 + T cell ...identified ...
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High frequencies of cytotoxic T cell precursors against minor Histocompatibility antigens after HLA-identical BMT. Absence of corrleation with Graft-versus-Host-Disease.
... We set out to quantify the anti recipient CTL response tnduced against minor Η antigens by HLA identical BMT and to monitor the kinetics of the anti minor CTLp frequency in time PBL of B[r] ...
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Human minor Histocompatibility antigens.
... For over five decades minor histocompatibility (mH) antigens have contmued to fascmate immimologists, mainly because of their minor but distinct role in transplantation but no less becau[r] ...
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Minor Histocompatibility antigens in man and their role in transplantation.
... associdtion between the HA 1,2,4 and 5 incompatibilities and the occurrence of GvHD Now that we have investigated almost twice the number of donor/recipient pairs, the latter correlation[r] ...
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Conservation of minor Histocompatibility antigens between human and non-human primates.
... served in evolution [8] Howevei until now no lnioima- tion existed on the evolutionary conseivation of human non-sex hnked mHag In the present study we investig ated whether the human no[r] ...
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Acquired tolerance for minor Histocompatibility antigens after HLA identical bone marrow transplantation.
... PBL of patients after HLA-identical BMT are known to contam CTLs reactive to host mH antigens present on patients' pre-transplant PBL (6,8) The observation that skin cells of a healthy f[r] ...
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A General Theory of Autoimmune Disease Causation: Integrating Innate and Adaptive Immunity, Altered Antigen Processing, Sex and Genetic Predispositions, and Microbiome Effects.
... In keeping with ACT, I propose that so-called “adjuvants” are complementary to the antigens they potentiate. This complementarity can be demonstrated by the formation of stable complexes (i.e., through ...
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Lack of effect of mouse adenovirus type 1 infection on cell surface expression of major histocompatibility complex class I antigens.
... I antigens present on the surface prior to infection remained at high levels and thus obscured detection of the effects of infec- tion on the synthesis, transport, and surface expression of newly synthesized class ...
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Effective Inhibition of Kb- and Db-Restricted Antigen Presentation in Primary Macrophages by Murine Cytomegalovirus
... (J774), MCMV infection did not lead to a decrease in cell surface class I expression. These results led the authors to conclude that macrophages could overcome the effects of the immune evasion genes and effectively ...
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Development of solid matrix antibody antigen (SMAA) complexes as multivalent subunit vaccines
... Initially, the traditional vaccination approach was taken using tlie whole inactivated SIV vaccines. These early vaccinations delayed or even prevented the onset of disease and successfully protected a proportion of ...
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Impairment of monocytic function during Trypanosoma cruzi infection.
... Finally, infected clone 53 showed a decreased ability to present antigen to major histocompatibility complex-matched T cells, which may relate to the absence of Class II antigens or to a[r] ...
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