miR-10b
miR-10b-5p expression in Huntington’s disease brain relates to age of onset and the extent of striatal involvement
... (miR-10b-5p, miR-196a- 5p, miR-196b-5p, miR-615-3p and miR-1247-5p) were significantly differentially expressed in this study ...expressed miR- NAs is likely due to an ...
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Original Article Demethylation of miR-10b plays a suppressive role in ccRCC cells
... 1. MiR-10b expression and CpG island methylation. A: MiR-10b expression levels were significantly lower in ccRCC tissues than that of in matched adjacent ...B: MiR-10b expression ...
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Original Article Circulating microRNAs, miR-10b-5p, miR-328-3p, miR-100 and let-7, are associated with osteoblast differentiation in osteoporosis
... showed miR- 328-3p, let-7g-5p, miR-133b, miR-22-3p, miR-2861, miR-518 miR-100 were down-regulated osteoporotic patient, while miR-10b-5p, miR-21, ...
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In silico analysis of regulatory networks underlines the role of miR 10b 5p and its target BDNF in huntington’s disease
... The results for the comparison of twelve HD and nine control brain samples is available from omiRas (http:// tools.genxpro.net/omiras/10eea4eb58d1/results/). Our analysis confirms the upregulation of ...
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The human nucleophosmin 1 mutation A inhibits myeloid differentiation of leukemia cells by modulating miR-10b
... of miR-10b [18]. MiR-10b is embedded in the homeobox (HOX) gene clusters ...that miR-10b could regulate metastasis, invasion and cell differentiation through targeting HOXD10 ...
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Original Article Effects of sleep deprivation on behaviors and abnormal hippocampal BDNF/miR-10B expression in rats with chronic stress depression
... of miR-10B increased in all of the ...of miR-10B in all of the rats (Figure 2A, ...that miR-10B targets the 3’UTR of BDNF with a high conservation (Figure 2A), which has not been ...
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miR 10b is overexpressed in hepatocellular carcinoma and promotes cell proliferation, migration and invasion through RhoC, uPAR and MMPs
... Japan). miR-10b was reverse transcribed by the looped primer, which binds to six nucleotides at the 3′ portion of miR-10b ...for miR-10b and other gene mRNA, ...for miR-10 ...
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Original Article miR-10b represses the proliferation and invasion of prostate cancer by targeting LRH1
... of miR-10b is deregulated in various cancers ...upregulated miR-10b expres- sion was observed in breast cancer [36], esophageal cancer [37], head and neck squa- mous cell carcinomas [38], ...
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MiR-10b decreases sensitivity of glioblastoma cells to radiation by targeting AKT
... of MiR-10b at 5 Gy of radiation. However, MiR-10b significantly increased p-AKT expression at 5 Gy of ...in MiR-10b mediated radioresistance of glioblastoma cells, SignalSilence ...
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Original Article Augmented miR-10b expression associated with depressed expression of its target gene KLF4 involved in gastric carcinoma
... of miR-10b can lead to down- regulation of KLF4 expression, stable miR-10b overexpres- sion cells were established using Lentivirus ...result, miR-10b expression was up-regulated ...
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CADM2, as a new target of miR-10b, promotes tumor metastasis through FAK/AKT pathway in hepatocellular carcinoma
... FAK is a focal adhesion-associated protein kinase involved in cellular adhesion and spreading processes. It is a critical mediator that connects integrin and the downstream signal molecules in integrin-signal trans- ...
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Role of miR 10b in breast cancer metastasis
... of miR-10b and RhoC, as well as upregulation of HOXD10, in highly metastatic breast tumor cells ...that miR-10b is controlled by the Twist binding site in its promoter region, and that ...
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Original Article Identification of the clinical diagnostic value of miR-10b-5p and the key targets and pathways in glioma, a study based on meta-analysis and bioinformatics
... The prepared data were further analyzed via the Student’s t test, receiver operating charac- teristic (ROC) curve analysis and meta-analysis using SPSS 24.0 (SPSS, Inc., Chicago, IL), GraphPad Prism 7.0 (GraphPad ...
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Acidic Microenvironment Up-Regulates Exosomal miR-21 and miR-10b in Early-Stage Hepatocellular Carcinoma to Promote Cancer Cell Proliferation and Metastasis
... identified miR-21 and miR-10b as the most important functional miRNAs in acidic HCC-derived ...exosomal miR-21 and miR-10b expression substantially promoting HCC cell ...
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Original Article Higher miR-10b expression contributes to malignant behaviors in gastric cancer in ex vivo and in vitro
... of miR-10b expression in gastric cells and ...of miR-10b expression in gastric cancer cells, expression of which was associated with tumor cell differentiation and lymph node metastasis ...
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miR-10b suppresses cell invasion and metastasis through targeting HOXA3 regulated by FAK/YAP signaling pathway in clear-cell renal cell carcinoma
... To construct a luciferase reporter vector, the RNA sequence of wide-type HOXA3 (HOXA3-WT) was PCR- amplified and inserted into the pGL3 luciferase pro- moter plasmid (Promega Corporation, Madison, WI, USA). HOXA3 RNA ...
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Original Article Diagnostic value of circulating miR-155, miR-21, and miR-10b as promising biomarkers in human breast cancer
... microRNAs, miR-155, miR-21, and miR-10b, to assess their diagnostic value in BC ...including miR-155, miR-21 and miR-10b, was constructed using multivariate ...
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MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma
... (i.e, miR-10b, miR-10a, miR-21) were further analyzed for pathway enrichment patterns for multiple cancer types (GBM, LGG, BRCA) using in-house tool PPEP analysis pipeline [58] using ...
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MicroRNA-10b regulates epithelial–mesenchymal transition by modulating KLF4/KLF11/Smads in hepatocellular carcinoma
... HCC. miR-10b locates in the HOX gene cluster on chromosome 2, suggesting that it is closely related to tumor invasion and ...that miR-10b was overexpressed in a variety of human can- cers, ...
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Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)
... serum miR-10b-3p level has been demonstrated to be useful in delineating ESCC stages due to the increasing expression of miR-10b-3p in higher-stage ...of miR-10b-3p ex- ...of ...
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