miR-135a
miR-135a promotes gastric cancer progression and resistance to oxaliplatin
... that miR-135a was overexpressed in GC samples relative to control ...high miR-135a expression were more likely to have aggressive characteristics (high levels of carcino-embryonic antigen, ...
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<p>miR-135a suppresses migration of gastric cancer cells by targeting TRAF5-mediated NF-κB activation</p>
... of miR-135a in 40 paired GC ...of miR-135a in comparison with those of non-metastatic GC tissues (N = 20; Figure ...of miR-135a with GC progression and ...lower ...
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LncRNA DANCR promotes the proliferation, migration, and invasion of tongue squamous cell carcinoma cells through miR-135a-5p/KLF8 axis
... bind miR-149 to positively regulate MSI2 expression and promote tumor malignant phenotypes in the pathogenesis of bladder cancer ...and miR-135a-5p, whether KLF8 was the downstream effector of DANCR/ ...
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<p>CircNOL10 Acts as a Sponge of miR-135a/b-5p in Suppressing Colorectal Cancer Progression via Regulating KLF9</p>
... with miR-135a-5p or miR-135b-5p. (A) Binding region between miR-135a-5p or miR-135b-5p and KLF9 3ʹUTR along with mutated nucleotides of KLF9 3ʹUTR was ...mimic, miR- ...
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<p>lncRNA ZFAS1 Is Involved in the Proliferation, Invasion and Metastasis of Prostate Cancer Cells Through Competitively Binding to miR-135a-5p</p>
... with miR-27a and reduce the expression of miR-27a, thereby regulating cell migration and ...with miR-484 as a ...and miR- 135a-5p, and ZFAS1 directly bound to miR-135a-5p ...
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<p>Downregulation of lncRNA NCK1-AS1 Inhibits Cancer Cell Migration and Invasion in Nasopharyngeal Carcinoma by Upregulating miR-135a</p>
... and miR-135a mimic (5 ʹ -UAUGGCUUUUUAUUCCU AUGUGA-3 ʹ ), as well as NC inhibitor (5 ʹ− GGCAGGUAA CGUGCGUUUCGA − 3) and miR-135a inhibitor (antisense) were all from Sangon (Shanghai, ...
7
Androgen-induced miR-135a acts as a tumor suppressor through downregulating RBAK and MMP11, and mediates resistance to androgen deprivation therapy
... Chromatin immunoprecipitation (ChIP) assay ChIP was performed as described previously. Chromatin immunoprecipitates for proteins were amplified by quantitative PCR, normalized to input, and calculated as percentages of ...
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Original Article Reactive oxygen species-upregulated miR-135a plays a pivotal role in phenethyl isothiocyanate-induced rat C6 glioma cell apoptosis
... as miR-27a, miR-491 and miR-135a, play pivotal roles in the response to ROS-inducing anti-tumor agents ...that miR-135a triggers rat C6 glioma cell apoptosis through mitochon- ...
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Exosomal miR-135a derived from human amnion mesenchymal stem cells promotes cutaneous wound healing in rats and fibroblast migration by directly inhibiting LATS2 expression
... The expression levels of individual miRNAs were ascer- tained using RT-PCR. The PrimeScript™ RT Reagent Kit (Jiangsu Synthgene Biotechnology Co., Ltd) was used to synthesize cDNA. SYBR Green qPCR assay (Jiangsu Synthgene ...
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Original Article miR-135a-5p affects adipogenic differentiation of human adipose-derived mesenchymal stem cellsby promoting the Hippo signaling pathway
... their miR-135a-5p levels. As shown in Figure 1A, miR-135a-5p expression in HPA-s and 3T3-L1 cells was higher than that in hADMSCs, indicating its upregulation in adipocytes (P < ...the ...
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Original Article miR-135a acts as a tumor suppressor by targeting ASPH in endometrial cancer
... We purchased three human EC cell lines: HEC- 1B, Kle, and AN3CA and one normal cell line: HEC-251 from the Shanghai Institute of Cell Biology of Chinese Academy of Sciences (Shanghai, China). Dulbecco’s Modified Eagle’s ...
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The relationship between the expression levels of miR-135a and HOXA10 gene in the eutopic and ectopic endometrium
... of miR-135a was synthesized using Bon-Mir RT kit (Bonyakhteh, Tehran, Iran) based on ’ ...as miR-135a as the target gene (Bonyakhteh, Tehran, Iran) (Table ...
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Plasma miR-135a; a potential biomarker for diagnosis of new type 2 diabetes (T2DM)
... of miR-135a in pre-diabetes and control crude model, we found no statistically significant difference of the figures after adjusting the covariates (Table ...of miR-135a as a prognostic value ...
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Mir 135a enhances cellular proliferation through post transcriptionally regulating PHLPP2 and FOXO1 in human bladder cancer
... cancer. MiR-409-3p is reported to be downregulated in bladder cancer and ectopic miR- 409-3p expression significantly reduced bladder cancer cell migration and invasion ...[30]. MiR-23b was found to ...
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miR-135a acts as a tumor suppressor in gastric cancer in part by targeting KIFC1
... for miR-135a targets by using MiRanda, TargetScan, and PicTar tools, and results identified KIFC1 as a putative target of miR-135a (Figure ...and miR-135a mimics had ...
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Expression and functional analysis of the Wnt/beta-catenin induced mir-135a-2 locus in embryonic forebrain development
... [83]. miR-135a is up regulated in several tumor types characterized by high levels of Wnt/beta-catenin signaling, including colorectal tumors as well as certain subtypes of medulloblastomas [74, ...duces ...
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Long noncoding RNA DANCR knockdown inhibits proliferation, migration and invasion of glioma by regulating miR-135a-5p/BMI1
... The emerging evidence has suggested that BMI1 acts as an oncogene in different cancers, and its overexpres- sion is associated with poor outcomes in several human cancers. For example, BMI1 promoted invasion and ...
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miRNA-135a promotes hepatocellular carcinoma cell migration and invasion by targeting forkhead box O1
... an miR-135a target that promotes HCC metastasis and pre- sents a novel mechanism of miRNA-mediated FOXO1 ...of miR-135a. The wound healing and Transwell assays showed that ...
7
MicroRNA-135a Inhibits Cell Proliferation by Targeting Bmi1 in Pancreatic Ductal Adenocarcinoma
... that miR-135a was significantly down-regulated in the PDAC cell ...of miR-135a by constructing a lentiviral vector to ex- press ...of miR-135a in PDAC cells decreased cell ...
13
MicroRNA-135a Regulates Apoptosis Induced by Hydrogen Peroxide in Rat Cardiomyoblast Cells
... whether miR-135a might regulates Bcl-2 during the development of cardiac cell injury, thereby affecting ischemic heart disease progression is not ...of miR-135a on apoptosis, and to ...
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