miR-24
miR 24 2 controls H2AFX expression regardless of gene copy number alteration and induces apoptosis by targeting antiapoptotic gene BCL 2: a potential for therapeutic intervention
... of miR-24-2 with the predicted binding sites of the genes. The miR-24-2 predicted binding sites in the 3’UTR of the BCL2 and H2AFX genes were amplified by using specific primers (Table S3 in ...
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The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma
... by miR-24 and ...that miR-24 promotes while Bim inhibits pancreatic tumor ...the miR-24-Bim pathway contributes to the complex network that activates pancreatic tumor growth and ...
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Original Article miR-24-3p suppresses cellar proliferation in hepatocellular carcinoma
... in miR- 24-3p mimics transfected HepG2 cells by flow ...mimic-NC, miR-24-3p overexpression group showed cell cycle arrest in G2/M phase 48 h after trans- fection (Figure ...of ...
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Multitargeting activity of miR-24 inhibits long-term melatonin anticancer effects
... oncogenic miR-24 as a miRNA strongly repressed by melatonin 72 hours post treatment (Figure 7, red arrow), which has p38, p53, PML and H2AX among its target genes (Figure ...of miR-24 after ...
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Original Article Role of miR-24 in myocardial fibrosis induced by angiotensin II
... of miR-24 in angiotensin II induced myocardial fibrosis enrich our understanding on myocardial fibro- sis and provide more possibilities for re- search of treatment target, drug development and even gene ...
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Original Article Association between mir-24 and mir-378 in formalin-fixed paraffin-embedded tissues of breast cancer
... ROC analysis was then performed to evaluate the capability of using the miRNAs to discrimi- nate between 101 patients and 40 controls. Optimum cutoff values were determined. As indicated in Table 1 and Figure 2, ...
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TRIM11, a direct target of miR-24-3p, promotes cell proliferation and inhibits apoptosis in colon cancer
... microRNAs, miR-24-3p has been shown to act as a cell type specific oncogene or tumor suppressor in a variety of cancers ...that miR-24-3p was downregulated in human CC tissues relative to ...
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MiR-24 functions as a tumor suppressor in nasopharyngeal carcinoma through targeting FSCN1
... Male BALB/c nude mice (4 ~ 5 weeks old) were pur- chased from the Medical Experimental Animal Center of Guangdong Province (Guangzhou, China). All protocols were approved by the Animal Care and Use Ethnic Committee. 1 × ...
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A common variant alters SCN5A–miR 24 interaction and associates with heart failure mortality
... relevant miR-target ...4,000 miR-target sites across more than 2,000 mRNAs (32), with approximately 50% of the sites overlap- ping coding ...between miR-24 and rs1805126, a synonymous SNP in ...
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Original Article Increased expression of miR-24 is associated with acute myeloid leukemia with t(8;21)
... of miR-24 and its clinical relevance in patients with acute myeloid leukemia ...the miR-24 expression levels using real-time quantitative PCR in 84 AML patients and investigated the clinical ...
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Plasma levels of microRNA-24, microRNA-320a, and microRNA-423-5p are potential biomarkers for colorectal carcinoma
... of miR-24, miR- 320a, and miR-423-5p had CRC diagnostic values, the ROC curve was applied to analyze their diagnostic sensitivity and specificity ...of miR-24 were ...of ...
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Expression profiling and bioinformatic analyses suggest new target genes and pathways for human hair follicle related microRNAs
... that miR-24 is an important regulator of hair morphogenesis and maintenance, which achieves its effect via the control of integrin and collagen ...of miR-24 target genes in the hormone ...
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miRNAs Expression and Role of Dicer on Podocyte Injury in PAN Nephrosis Rats
... ysis. 3) Compared with control sample, immune fluorescence intensity of dicer, expression profile of nephrin, podocin and synaptopodin mRNA and protein decrease in PAN nephrosis rats. After treated with Leizhi Capsule, ...
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MicroRNA-24 inhibits growth, induces apoptosis, and reverses radioresistance in laryngeal squamous cell carcinoma by targeting X-linked inhibitor of apoptosis protein
... of miR- NAs may play important roles in LSCC progression and de- ...velopment. MiR-24 is an abundant miRNA encoded by the corresponding gene that maps to human chromosome 9q22 and 19p13 regions, ...
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The NF-κB p65/miR-23a-27a-24 cluster is a target for leukemia treatment
... the miR-23a-27a-24 cluster with erythroid protein ...the miR-23a-27a-24 cluster in physiological erythropoiesis, but it is clear that expression levels of this protein and the miRNA cluster ...
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Advance in microRNA as a potential biomarker for early detection of pancreatic cancer
... including miR-20a, miR-21, miR-24, miR-25, miR-99a, miR-185, miR-191, differentially expressed in pancreatic cancer compared to cancer-free subjects, suggesting ...
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Intrinsic expression of host genes and intronic miRNAs in prostate carcinoma cells
... of miR 106b-25 cluster are downregulated by 2–5 fold in LNCaP, PC-3 and DU 145 cells as compared to their expression in MDA PCa 2b cells (Figure 5A & table ...the miR 23b-24 cluster, the ...
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miR-195-5p/NOTCH2-mediated EMT modulates IL-4 secretion in colorectal cancer to affect M2-like TAM polarization
... each), miR-195-5p agomir or miR agomir NC (RiboBio, Guangzhou, China) was directly injected into the implanted tumor at the dose of 2 nmol/ 50 μL PBS, and THP1-induced macrophages were injected into the ...
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MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway
... that miR-330-3p was up-regulated in the blood of patients with prostate cancer and primary plasma cell leukemia [32, ...Moreover, miR-330-3p expression was found to be increased in the tissues of NSCLC ...
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Original Article MicroRNA-137 suppresses cell migration and invasion in renal cell carcinoma by targeting PIK3R3
... as miR-132 [27], miR-511 [16], miR-193a- 3p [26] and miR-7 ...of miR-137 by lucif- erase reporter assay. miR-137 overexpression in RCC cells obviously inhibited PIK3R3 expres- ...
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