miR-27a/b
miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)
... Damaged mitochondria are selectively tagged by a combin- ation of PINK1 and Parkin and then, delivered to lysosome for hydrolytic degradation [11]. Therefore, we next exam- ined whether miR-27a/b ...
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MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2
... that miR-27a and -b efficiently inhibit infection with an Ad via the downregulation of SNAP25 and TXN2, which are members of the SNARE pro- teins and the thioredoxin family, ...with ...
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Negative auto-regulation of myostatin expression is mediated by Smad3 and MicroRNA-27
... of miR-208a in the heart has been shown to result in cardiac hypertrophy together with reduced expression of Mstn ...of miR-499 leads to reduced Mstn 39UTR activity, suggesting that Mstn is a target of ...
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miR-27a and miR-27a* contribute to metastatic properties of osteosarcoma cells
... and MIR-27a expression in OS clinical ...that miR-27a represses CBFA2T3 translation rather than facilitates mRNA ...for miR-27a targets, which expression is inversely correlated ...
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MiR-27a-3p functions as an oncogene in gastric cancer by targeting BTG2
... The B-cell translocation gene 2 (BTG2) has been implicated in gastric ...between miR-27a and BTG2 in gastric cancer has not been ...mature miR-27a, miR-27a-5p and ...
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Obesity-associated miR-27a upregulation promotes hepatocellular carcinoma metastasis through suppressing SFRP1
... The miR-27a levels of adipose tissue, liver, and serum were also significantly higher in the HF group than the control group (Figure 4B). To study the molecular mechanisms of the HCC metastasis under ...
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Coordinated Targeting of the EGFR Signaling Axis by MicroRNA- 27a*
... identified miR-27a (miR-27a-3p) and its complementary or star (*) strand, miR-27a* (miR-27a-5p), as novel miRNAs targeting EGFR, which were significantly ...
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MiR-27a ameliorates inflammatory damage to the blood-spinal cord barrier after spinal cord ischemia: reperfusion injury in rats by downregulating TICAM-2 of the TLR4 signaling pathway
... with miR mimics and AMOs was is one of the most common and useful methods to regulate the ex- pression levels of miRs ...injecting miR mimics 48 hours before IR greatly downregulated the levels of ...
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Effect of miR-27a-3p on Proliferation and Migration in Non-small Cell Lung Cancer Cells
... of miR-15a and miR-16-1 in the 13q14 region was associated with B-cell chronic lymphocytic leukemia (Calin et ...that miR-373 was down-regulated by histone modification in lung cancer cells ...
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Original Article miR-27a promotes cell proliferation and metastasis in renal cell carcinoma
... of miR-27a on cell lines proliferation and ...that miR-27a significantly enforced RCC cell proliferation in ACHN ...cells. B. MiR-27a significantly enforced RCC cell ...
8
Dysregulated miRNA Associated with Transcription Factors of Insulin Gene Expression in Chronic Pancreatitis
... Among the 25 differentially expressed miRNA, a few clusters of miRNA miR-29a/29b/29c, miR-200a/200b/200c/141, miR-216/217, miR-30a/30b/30c, miR-27a/27b/24/23b were noted to be associated[r] ...
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MiR-424 and miR-27a increase TRAIL sensitivity of acute myeloid leukemia by targeting PLAG1
... after miR-424&27a upregulation or PLAG1 downregulation (Figure 5, ...with miR-424 and miR-27a while positively associated with PLAG1 expression (Figure 6D, ...either ...
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Association of the peripheral blood levels of circulating microRNAs with both recurrent miscarriage and the outcomes of embryo transfer in an in vitro fertilization process
... that miR-29a has been explored as a potential predictive biomarker for out- comes of the IVF process [38], we also observed an asso- ciation between the peripheral blood levels of these six miRs and the outcomes ...
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MiR 1 3p that correlates with left ventricular function of HCM can serve as a potential target and differentiate HCM from DCM
... found miR-155, miR-10b and miR-23a were highly expressed in both HCM and DCM compared with ...control. MiR-214 was downregulated and miR-21 was upregulated in DCM but not in ...
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Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases
... the level of miR-181a expression in the ER-positive tumor was higher than that in the ER-negative tumor, while reduced expression was noted for miR-27a, miR-107, and miR-195 in the ER[r] ...
5
Aberrant plasma levels of circulating miR-16, miR-107, miR- 130a and miR-146a are associated with lymph node metastasis and receptor status of breast cancer patients
... of miR-130a and miR-146a correlated with lymph node- negative and HER2-positive status of the ...that miR-130a affects cell proliferation, but has no apoptotic effect, miR-130a was described ...
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A double feedback loop mediated by microRNA-23a/27a/24-2 regulates M1 versus M2 macrophage polarization and thus regulates cancer progression
... Additionally, miR-27a regulates the inflammatory response of macrophages by targeting IL-10 [33], indicating that miR- 27a, a member of the miR-23a/27a/24-2 cluster, may play an ...
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Extracellular Vesicles in Malaria Infection
... the combination of these reticulocyte-derived EVs and CpG-ODN to BALB/c mice leads to significant increase in the percentage of effector T cells of both CD4 and CD8 T cells, especially effector memory CD4 subset when ...
6
<p>MicroRNA-27a downregulates the expression of Hsp90 and enhances the radiosensitivity in esophageal squamous cell carcinoma</p>
... Protein were extracted 48 h after Eca109 and Eca9706 cells were transfected with miR-NC or miR-27a mimics. For combination, cells were irradiated with single dose of 6 Gy rays after 24 h of ...
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The NF-κB p65/miR-23a-27a-24 cluster is a target for leukemia treatment
... To determine whether the p65/miR-23a-27a-24 cluster is associated with erythroid differentiation, BMDCs were cultured in erythroid differentiation medium for 10 days using a protocol that was described ...
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