miR-486
Direct repression of the oncogene CDK4 by the tumor suppressor miR-486-5p in non-small cell lung cancer
... that miR-486-5p was significantly downregulated in non-small cell lung cancer (NSCLC) tissues and cell lines, suggesting that miR-486-5p might function as a tumor suppressor in lung ...of ...
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miR-486-5p attenuates tumor growth and lymphangiogenesis by targeting neuropilin-2 in colorectal carcinoma
... of miR-486-5p on NRP2 expression as determined by a luciferase reporter ...with mir-486-5p mimic (mir-486-5p group), mimic control (nc group), and blank control (blank ...of ...
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<p>Downregulation of miR-486-5p Enhances the Anti-Tumor Effect of 5-Fluorouracil on Pancreatic Cancer Cells</p>
... that miR-486-5p served as a biomarker in various kinds of tumors, including non-small cell lung cancer, prostate ...of miR-486-5p was signi fi cantly upregulated in patients with pancreas ...of ...
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Original Article MiR-486-5p inhibits metastasis by targeting neuropilin-2 in gastric cancer
... of miR-486-5p in gas- tric cancer cell proliferation, a SGC-7901 cell line stably overexpressing miR-486-5p was established using plasmid transfection, and then used to conduct an experimental ...
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Original Article miR-486 inhibits Gli1 expression and attenuates epithelial mesenchymal transition and invasion of prostate cancer
... of miR-486 is decreased in multiple tumors such as non- small cell lung cancer [21], colorectal cancer [22], cervical cancer ...of miR-486 is associated with prostate cancer Figure 4. Elevated ...
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<p>The lncRNA LINC01194/miR-486-5p Axis Facilitates Malignancy in Non-Small Cell Lung Cancer via Regulating CDK4</p>
... that microRNAs, as upstream regulators of multi-gene multi-target regulation, are involved in the regulation of post-transcriptional gene expression. 38 At present, a variety of microRNAs were found to be dysregulated in ...
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Upregulation of circFLNA contributes to laryngeal squamous cell carcinoma migration by circFLNA–miR-486-3p-FLNA axis
... transfected miR-486-3p decreased the miR-486-3p level in Hep2 cells, compared with the negative ...the miR-486-3p-binding site (wt or mut) and miR-486-3p ...
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<p>Circular RNA circHUWE1 Is Upregulated and Promotes Cell Proliferation, Migration and Invasion in Colorectal Cancer by Sponging miR-486</p>
... Results: In this study, we demonstrate that the expression of circHUEW1 is upregulated in CRC tissues. High expression of circHUEW1 was signi fi cantly associated with lymphovas- cular invasion (P =0.036), lymph node ...
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miR-486-5p suppresses prostate cancer metastasis by targeting Snail and regulating epithelial–mesenchymal transition
... with miR-486-5p was synthesized and cloned downstream of the Renilla luciferase gene in psiCHECK-2 vector (Promega, Madison, WI, ...with miR-486-5p mimics or scramble ...
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miR-486 is modulated by stretch and increases ventricular growth
... with miR-486 also identified a possible reduction in sarcomeric proteins, titin, myosin (Myh6), and myosin light chain (Myl3) (Figure ...from miR-486–treated mice did not reveal any signif- ...
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<p>MiR-486-5p Act as a Biomarker in Endometrial Carcinoma: Promotes Cell Proliferation, Migration, Invasion by Targeting MARK1</p>
... and miR-486-5p can speci fi cally target various genes in the involvement of tumor progressions such as fi bril- lin-1 in papillary thyroid carcinoma, 23 PTEN in cervical cancer, 16 OLFM4 in gastric cancer 14 ...
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Original Article MiR-486-5p prevents migration, invasion and EMT by regulating Smad2 in breast cancer
... of miR-486-5p was performed by using miScript SYBR Green PCR Kit (Qiagen GmbH) following the manufacturer’s ...follows: miR- 486-5p-forward, 5’TCC TGT ACT GAG CTG CCC CGAG3’ [the reverse ...
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Identification in GRMD dog muscle of critical miRNAs involved in pathophysiology and effects associated with MuStem cell transplantation
... In situ hybridization (ISH) was performed on muscles from healthy, GRMD, mock GRMD and GRMD MuStem dogs, using digoxigenin (DIG)-labelled miRCURY locked nucleic acid (LNA) detection probes (Exiqon, Vedbaek, Denmark), ...
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Original Article MicroRNA-486-5p down-regulation protects cardiomyocytes against hypoxia-induced cell injury by targeting IGF-1
... of miR-486- 5p on hypoxia-induced cardiomyocyte injury to reveal the role of miR-486-5p in cyanotic congenital heart disease ...of miR-486-5p in hypoxia-induced H9C2 ...of ...
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Specific circulating microRNA signature of bicuspid aortic valve disease
... hsa- mir-130a-3p), 5 ′ -CAGUGCAAUGUUAAAAGGGC AU-3 ′ ; microRNA-486-5p (miR-486-5p; hsa-mir- 486-5p), 5 ′ -UCCUGUACUGAGCUGCCCCGAG-3 ′ Table 2 Clinical and echocardiographic ...
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Regulation of DMD pathology by an ankyrin-encoded miRNA
... The miR- 486-transgenic mice showed significantly decreased mRNA expression of the miR-486 downstream target genes (mRNA for Pdgfrb and Foxo1) in their skeletal muscles at specific time points ...
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Inflammation associated microRNA changes in circulating exosomes of heart failure patients
... in miR-146a and miR-486 levels between patients with heart failure and ...circulating miR-486 levels in breast cancer ...of miR-486 and miR-146a were converted to ...
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Original Article MicroRNA-486-5p targets FGF9 and inhibits colorectal cancer proliferation, migration and invasion
... plates. miR-486-5p mimic or miR-NC was transfected into SW620 and HCT116 cells using Lipofectamine 2000 (In- vitrogen) according to the manufacturer’s pro- ...
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Mixed mode GPS network processing for deformation monitoring applications in the equatorial region
... Figure 2: Hong Kong GPS Active Network stations used in this study 4.1 Ionospheric Corrections for the Fiducial Baselines Processing the dual-frequency data with a modified version of th[r] ...
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In Vitro Inhibition of Human Melanoma (BLM) Cell Growth by Progesterone Receptor Antagonist RU 486 (Mifepristone)
... growth. RU-486 is a synthetic steroid and is a progesterone receptor antagonist [6]. RU-486 also binds to glucocorticoid receptor and is also considered as a glucocorticoid receptor antagonist [7]. ...
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