miR-497
Original Article miR-497 inhibits the carcinogenesis of hepatocellular carcinoma by targeting the Rictor/Akt signal pathway
... of miR-497 on Rictor, 293T cells were transfected with Rictor luciferase reporter plasmid, with their 3’-UTR regions containing of miR-497 binding sites or corresponding mutant sites, and the ...
9
miR-497 suppresses epithelial–mesenchymal transition and metastasis in colorectal cancer cells by targeting fos-related antigen-1
... of miR-497 (Figure ...of miR-497 in HCT116 and SW480 cells caused the marked reduction in Fra-1 mRNA and protein ...of miR-497 inhibited luciferase activity in 3 ′ UTR-WT, but it ...
8
lncRNA XIST regulates proliferation and migration of hepatocellular carcinoma cells by acting as miR-497-5p molecular sponge and targeting PDCD4
... that miR- 497-5p was upregulated in the HCC cell lines (shown in ...a miR-497-5p inhibitor to assess the biological effect of miR-497-5p in HCC ...the ...
13
miR-497-5p inhibits cell proliferation and invasion by targeting KCa3.1 in angiosarcoma
... miRNAs, miR- 497 is down-regulated in breast, gastric, and colorectal cancer and promotes cell proliferation and invasion by up- regulating raf-1/Ccnd1, EIF4E, and insulin growth factor 1 receptor in ...
14
<p>LncRNA SNHG16 drives proliferation and invasion of papillary thyroid cancer through modulation of miR-497</p>
... and miR-497 were explored by luciferase reporter assay and ...for miR-497 to regulate its target genes brain-derived neurotrophic factor and yes-associated protein 1 ...of ...
10
Original Article mir-497 inhibits cell migration and invasion by targeting FASN in human osteosarcoma cells
... (miRNAs, miR) are small noncoding RNAs with a length of 20-22 nucleotides (nt) and widely exist in eukaryotes ...15]. miR-497 is a poten- tial tumor suppressor gene located on the miRNA cluster site ...
9
miR-497 inhibited proliferation, migration and invasion of thyroid papillary carcinoma cells by negatively regulating YAP1 expression
... and miR-497 were determined by TargetScan, and according to the forecast result, mutant sequences and wild-type sequences of the binding sites were designed ...and miR-497 mimics, or mutant ...
11
miR-145 and miR-497 suppress TGF-β-induced epithelial–mesenchymal transition of non-small cell lung cancer by targeting MTDH
... Since miR-145 and miR-497 were downregulated in NSCLC cell lines, we then investigated the role of miR- 145 and miR-497 in TGF-β-induced cancer cell migra- tion and ...either ...
9
miR-497 and miR-34a retard lung cancer growth by co-inhibiting cyclin E1 (CCNE1)
... deletion. miR- 34a, located at 1p36, has been extensively studied as a microtumor suppressor [33, 34], and miR-497, located at ...that miR-497 is downregulated in lung cancer [25]; ...
15
MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1
... of miR-497 on HCC angiogenesis, in vitro endothelial recruitment and capillary tube formation assays were performed with two HCC cell lines, Huh7 and ...of miR-497 expression could be verified ...
16
Original Article MiR-497 induces hepatocellular carcinoma cell LM3 apoptosis through downregulating XIAP
... nmol miR-497 mimic (or miR-497 inhibitor, or negative control) and 50 ng inter- nal control plasmid pRL-TK mixture mediated by Lipofectamine ...5’-UUCUCCGAACGUGUCACGUTT-3’; MiR- ...
10
MiR-497 decreases cisplatin resistance in ovarian cancer cells by targeting mTOR/P70S6K1
... of miR-497, highlighting the potential role of miR-497 downregulation for ovarian cancer cells to develop a chemoresistance ...that miR-497 could suppress both mTOR and p70S6K1 ...
15
Original Article Down-regulation of miR-497 is associated with poor prognosis in renal cancer
... that miR-630 expression was to be associated with gastric cancer invasion, lymph node metasta- sis, distant metastasis and TNM stage ...that miR-152 was down-regu- lated in non-small cell lung cancer ...
7
<p>Circular RNA Profiling Reveals That circRNA_104433 Regulates Cell Growth by Targeting miR-497-5p in Gastric Cancer</p>
... Recently, several studies have reported that decreased CDC25A expression might inhibit malignant progression by suppressing cell-cycle pathway. 7,21,22 Similarly, CDC25A plays a unique role in activating cyclin B1- Cdk1 ...
16
Tanshinone IIA regulates human AML cell proliferation, cell cycle, and apoptosis through miR-497-5p/AKT3 axis
... of miR-497-5p via the public miRNA database, miRDB, and found that AKT3, serine/threonine protein kinase that plays an important role in cell proliferation, apoptosis, and migration, was a suitable target ...
12
<p>Long Non-Coding RNA CDKN2B-AS1 Facilitates Laryngeal Squamous Cell Cancer Through Regulating miR-497/CDK6 Pathway</p>
... that miR-497 overexpression obviously suppressed the luciferase activ- ity of WT-CDKN2B-AS1 in TU212 cell, but not of MT- CDKN2B-AS1 (Figure ...and miR-497 were enriched in TU212 cells ...
10
miR-497 expression, function and clinical application in cancer
... describe miR-497 as mainly a tumor suppressor ...elevated miR-497 can provide a novel therapeutic approach to inhibit multiple proteins involved in the formation and progression of ...
12
The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L
... tissues, miR-497, was present at significantly lower levels in NPC plasma than in noncancerous control plasma (P < ...of miR-497 was significantly correlated between tissues and plasma ...
15
MiR-497-5p, miR-195-5p and miR-455-3p function as tumor suppressors by targeting hTERT in melanoma A375 cells
... of miR-497-5p, miR-195-5p, miR-455-3p and hTERT mRNA was determined by ...Results: MiR-497-5p, miR-195-5p, miR-455-3p were significantly downregulated, while hTERT ...
15
Association of miR-497-5p and miR-4417 Expression in Oral Squamous Cell Carcinoma and Clinical Parameters
... another miR- 497-5p target, is a transmembrane receptor activated by IGF1 and IGF2, and its over-expression has also been associated with OSCC (9, ...Other miR-497-5p targets are the MYC ...
14