Mismatch repair
Distinct Roles for the Saccharomyces cerevisiae Mismatch Repair Proteins in Heteroduplex Rejection, Mismatch Repair and Nonhomologous Tail Removal
... cerevisiae mismatch repair (MMR) protein MSH6 and the SGS1 helicase were recently shown to play similarly important roles in preventing recombination between divergent DNA sequences in a single-strand ...
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The Large Loop Repair and Mismatch Repair Pathways of Saccharomyces cerevisiae Act on Distinct Substrates During Meiosis
... a mismatch will be ...DNA mismatch repair ...systems, mismatch repair (MMR) and large loop repair (LLR), have been identified previously, but the substrate range of these ...
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Mismatch repair-induced meiotic recombination requires the pms1 gene product.
... The pmsl-1 mutation reduces the frequency of mismatch repair-induced events: We wished to test the hypothesis that the repair of heteroduplex DNA containing closely [r] ...
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Control of GT Repeat Stability in Schizosaccharomyces pombe by Mismatch Repair Factors
... Sidransky, D., 1997 Nucleic acid-based methods for the detection Wang, T.-F., N. Kleckner and N. Hunter, 1999 Functional speci- of cancer. Science 278: 1054–1058. ficity of MutL homologs in yeast: evidence for three ...
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Mutation Rates, Spectra and Hotspots in Mismatch Repair-Deficient Caenorhabditis elegans
... DNA mismatch repair (MMR) plays a critical role in maintaining genomic stability in nearly all forms of life surveyed, much remains to be understood about the genome- wide impact of MMR on spontaneous ...
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Mismatch Repair Mutants in Yeast Are Not Defective in Transcription-Coupled DNA Repair of UV-Induced DNA Damage
... coli mis- match repair mutants, we found that mutations in yeast mismatch repair genes had no discernable effect upon either transcription-coupled repair or global nucleotide [r] ...
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Regulation of Mitotic Homeologous Recombination in Yeast: Functions of Mismatch Repair and Nucleotide Excision Repair Genes
... bacterial mismatch repair proteins MutS and MutL correct replication errors and prevent recombination between homeologous (nonidentical) ...excision repair proteins Rad1p and Rad10p were found to ...
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Frequent mismatch-repair defects link prostate cancer to Lynch syndrome
... of mismatch repair (MMR) defective tu- mors of these subtypes and demonstration of an increased risk of these tumor types in mutation carriers [3 – ...
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Defective mismatch repair and DNA damage sensing in human cells
... base. Repair of the w rong (correct base-containing), strand would result in m utation ...the mismatch can involve the excision and resynthesis of a relatively long tract of DNA, up to ...patch ...
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Mismatch repair deficiency may be common in ductal adenocarcinoma of the prostate
... the mismatch repair (MMR) genes (2 in MSH2, 1 in MSH6 and 1 in MLH1), of which 3 (75%) had evidence of hypermutation associated with microsatellite instability ...
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The Effect of Mismatch Repair and Heteroduplex Formation on Sexual Isolation in Bacillus
... the mismatch repair system, and (5) successful functioning of the do- nor gene product, which requires functional compati- bility of the donor gene product with the recipient cell’s genetic background and ...
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The Yeast HSM3 Gene Acts in One of the Mismatch Repair Pathways
... We transformed yeast cells with plasmid heteroduplex DNAs, each containing defined mismatches. We found that these mismatches were repaired efficiently in the wild-type cells. Repair of these mismatches, however, ...
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Saturation of DNA Mismatch Repair and Error Catastrophe by a Base Analogue in Escherichia coli
... ture of bacteria (0.1 ml) was mixed with molten 0.7% agar mutability of mismatch-repair-defective mutH, -L, and containing 0.9% NaCl and poured onto a minimal glucose -S derivatives. We found that in the ...
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Dynamics of DNA Mismatch Repair Initiation Complexes Revealed by Single Molecule Fluorescence.
... Recent studies of E. coli MutS using mass spectroscopy (Monti et al, 2011) or AFM (Jiang & Marszalek, 2011) observed MutS tetramers interacting with mismatched DNA. Tetramerization may be more significant in these ...
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Mismatch repair gene defects in sporadic colorectal cancer enhance immune surveillance
... A retrospective analysis was performed on 113 consecutive patients operated on for CRC at the Surgical Dept. of the Treviso Regional Hospital from 2009 to 2010. Their familial and medical history was retrieved. In ...
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Functional role of DNA mismatch repair gene PMS2 in prostate cancer cells
... DNA mismatch repair (MMR) enzymes act as proofreading complexes that maintains genomic integrity and MMR-deficient cells show an increased mutation ...
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DNA mismatch repair gene MSH6 implicated in determining age at natural menopause
... We identified a novel variant associated with age at natural menopause which is a synonymous exonic SNP in the MSH6 gene on chromosome 2. The SNP had a minor allele frequency of 18% and the rare allele increased ...
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Prognostic implications of mismatch repair deficiency in patients with nonmetastatic colorectal and endometrial cancer
... Background The clinical relevance of mismatch repair (MMR) status in patients with nonmetastatic cancer across tumour types remains unclear. Our goal was to investigate the prognostic role of MMR deficiency ...
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Role of Mismatch Repair in the Fidelity of RAD51- and RAD59-Dependent Recombination in Saccharomyces cerevisiae
... Prolla, T. A., D.-M. Christie and R. M. Liskay, 1994 Dual require- Welz-Voegele, C., J. E. Stone, P. T. Tran, H. M. Kearney, R. M. ment in yeast DNA mismatch repair for MLH1 and PMS1, two Liskay et al., ...
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The Effects of Mismatch Repair and RAD1 Genes on Interchromosomal Crossover Recombination in Saccharomyces cerevisiae
... We have previously shown that recombination between 400-bp substrates containing only 4-bp differ- ences, when present in an inverted repeat orientation, is suppressed by .20-fold in wild-type strains of S. cerevisiae. ...
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