Mitochondrial dysfunction
Mitochondrial dysfunction during different sepsis forms
... and mitochondrial dysfunction in critically ill ...multiorgan dysfunction (Levy Richard, 2007; Vincent, 2007; Protti Alessandro and Singer Mervyn, 2006; Michael ÉvertonAndrades et ...
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Mitochondrial dysfunction in patients with primary congenital insulin resistance
... Mitochondrial dysfunction is associated with insulin resistance and type 2 ...in mitochondrial function may lead to accumulation of toxic lipid species in muscle and elsewhere, impairing insulin ...
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Mitochondrial dysfunction in Autism Spectrum Disorders
... as mitochondrial disease and abnormalities of energy ...of mitochondrial electron transport chain (ETC) complexes and reduced gene expression of mitochondrial genes, in particular genes of ...
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Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure?
... on mitochondrial dysfunction under ischemic and inflammatory conditions are sometimes contradic- ...of mitochondrial biogenesis after hypoxia has been shown in a variety of ...of mitochondrial ...
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Mitochondrial Dysfunction in Duchenne Muscular Dystrophy
... between mitochondrial dysfunction and DMD where increased intra- cellular and inter-mitochondrial calcium has been shown to cause mitochondrial swelling, loss of mitochondrial membrane ...
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MH84 improves mitochondrial dysfunction in a mouse model of early Alzheimer’s disease
... improving mitochondrial dysfunction in models of neurodegenerative diseases [20, ...23] mitochondrial dys- function contributes to an impairment of the energy metab- olism, defects in key respiratory ...
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The role of mitochondrial dysfunction in acute pancreatitis
... The alternative pathway of ethanol metabolism is the non-oxidative pathway. Non-oxidative ethanol metabolism involves the formation of fatty acid ethyl esters (FAEE). FAEE are the products of esterified ethanol and fatty ...
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Effects of mitochondrial dysfunction on the immunological properties of microglia
... to mitochondrial dysfunction [13], and an impairment of mitochondrial activity has been observed in cells and tissues isolated from patients with neurode- generative ...the mitochondrial ...
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Early-onset Parkinson disease caused by a mutation in CHCHD2 and mitochondrial dysfunction
... The mitochondrial toxicity of oxidized dopamine derivatives, in combination with the inherently low mitochondrial mass of DA neurons, may potentiate mitochondrial dysfunction resulting from ...
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Iron-Mediated Inhibition of Mitochondrial Manganese Uptake Mediates Mitochondrial Dysfunction in a Mouse Model of Hemochromatosis
... The mitochondrial dysfunction in Hfe –/– mice, evidenced by decreased oxygen consumption, is consistent with oxidative damage and lipid ...that mitochondrial iron accumulation resulting in generation ...
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Mitochondrial dysfunction in psychiatric morbidity: current evidence and therapeutic prospects
... while mitochondrial dysfunction is a common characteristic of distinct psychiatric disorders, the particular profiles differ in magnitude and temporal ...
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Human Mitochondrial Transcription Factor A Reduction and Mitochondrial Dysfunction in Hashimoto’s Hypothyroid Myopathy
... ity-induced mitochondrial biogenesis ...primary mitochondrial dysfunction, as in mitochondr- ial myopathies due to nuclear or mitochondrial genome ...of mitochondrial DNA copy number, ...
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Mitochondrial Dysfunction in Skeletal Muscle of Children With Cardiomyopathy
... mitochondrial dysfunction. There is increasing evidence that mitochondrial diseases, such as mitochondrial CM and some myopathies, can be responsive to treatment with metabolic inter- mediates ...
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Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets
... in mitochondrial pathways, to decrease oxygen consumption and ATP content, to increase mtCa 2+ load and ROS production (Piccoli et ...of mitochondrial morphology in triso- mic fetal fibroblasts demonstrated ...
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Alpha-Synuclein Toxicity is Caused by Mitochondrial Dysfunction
... Mitochondrial dysfunction is clearly a major hallmark of PD and a major phenotype in many PD models, and aSyn is known as a key disease protein in ...to mitochondrial dysfunction as key ...
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The emerging role of cardiovascular risk factor-induced mitochondrial dysfunction in atherogenesis
... with mitochondrial dysfunction, as suggested by decrease in mitochondrial transmembrane potential and activation of the mitochondrial apoptosis pathway, a process playing a key role in ...the ...
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Mitochondrial dysfunction and oxidative stress in aging and cancer
... mTOR pathway is involved in both senescent phenotype and cancer, which have been extensively studied by Blagosklonny and colleagues. mTOR pathway drives the process of conversion from proliferative arrest to irreversible ...
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Mitochondrial dysfunction in pathophysiology of heart failure
... drial dysfunction has been widely observed in the failing heart irrespective of ...this dysfunction is recognized as a maladaptive response, specific mechanisms connecting mito- chondrial dysfunction ...
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ASSESSING THE RELATIONSHIP OF MITOCHONDRIAL DYSFUNCTION WITH AGE-RELATED DECLINE IN FEMALE FERTILITY
... to mitochondrial dysfunction is considered to be the cause of agerelated changes in somatic ...any dysfunction of which might have profound detrimental effect on the embryonic ...Therefore, ...
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Neuronal degeneration and mitochondrial dysfunction
... with mitochondrial disease tells us little about neuronal cell death in these ...to mitochondrial dysfunction — ...and mitochondrial dysfunction still awaits a direct, clear, and ...
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