mitochondrial fusion
Low-dose ionizing radiation induces mitochondrial fusion and increases expression of mitochondrial complexes I and III in hippocampal neurons
... change mitochondrial dynamics, neurons treated with 0, ...of mitochondrial outer membrane, to mark mitochondria ...of mitochondrial fusion but not to the degree observed in ...
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A novel cell-free mitochondrial fusion assay amenable for high-throughput screenings of fusion modulators
... the fusion reaction, we isolated cytosols from drug-treated sHeLa cells to activate different path- ...the fusion reac- tion (Figure ...mammalian mitochondrial fusion. In contrast to the ...
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The Role of Mitofusin Proteins in Mitochondrial Fusion and Disease
... in mitochondrial dynamics are not catastrophic because only the neurons with the highest demands for precise control of mitochondrial fusion are ...
163
Dichloroacetate Stabilizes Mitochondrial Fusion Dynamics in Models of Neurodegeneration
... of mitochondrial fusion rates was based on that of Karbowski et ...cellular mitochondrial matrix (photoconverting mitochondria-expressed GFP to a state of ∼ 20-fold increased fluorescence in a small ...
10
Mitochondrial fusion exploits a therapeutic vulnerability of pancreatic cancer
... of mitochondrial fission promotes mitochondrial fusion and suppresses ...promotes mitochondrial fission (10). Whether disrupting mitochondrial fission would have a therapeutic effect in ...
17
Mitochondrial fusion and fission are involved in stress tolerance of Candida glabrata
... of mitochondrial fusion could also effectively improve ATP production and help maintain the mitochondrial membrane potential (ΔΨm), which may be another reason for the high tolerance of strain ...the ...
9
Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stability
... M2-type pyruvate kinase (PKM2) contributes to the Warburg effect. However, it remains unknown as to whether PKM2 has an inhibitory effect on mitochondrial function. We report in this work that PKM2 overexpression ...
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Promotion of mitochondrial fusion protects against developmental PBDE-47 neurotoxicity by restoring mitochondrial homeostasis and suppressing excessive apoptosis
... in mitochondrial morphology are known to affect mitochondrial function ...view, mitochondrial dysfunction was observed in PBDE-47-treated PC12 cells in which mitochondria were ...elevated ...
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Mechanisms of mitochondrial fusion and fission
... in mitochondrial fission display net-like mitochondrial morphology due to unop- posed mitochondrial fusion (Bleazard et ...These mitochondrial nets can have a spread mor- phology ...in ...
132
Cross-Talk Between Mitochondrial Fusion and the Hippo Pathway in Controlling Cell Proliferation During Drosophila Development
... between mitochondrial function and the Hippo pathway has been recently discovered in both flies and mammalian cells (Nagaraj et ...increased mitochondrial fusion, in addition to cell overproliferation ...
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A genetic system controlling mitochondrial fusion in the slime mould, Physarum polycephalum.
... In the cross between r n z f X m z f strains, we dem- onstrated previously that the transmission of mtDNA is uniparental; the resultant plasmodia carry mtDNA of only one[r] ...
12
<p>Mitochondrial Dynamic Dysfunction as a Main Triggering Factor for Inflammation Associated Chronic Non-Communicable Diseases</p>
... to mitochondrial dysfunction. Mitochondrial dys- function is a condition characterized by loss of membrane potential to decrease Adenosine Triphosphate (ATP) produc- tion, decrease respiration or oxidative ...
11
Dominant optic atrophy, OPA1, and mitochondrial quality control: understanding mitochondrial network dynamics
... as mitochondrial DNA maintenance ...the mitochondrial inner membrane, together with MFN1 and MFN2 on the mitochondrial outer membrane, is necessary for mitochondrial fusion and that ...
12
“Mitochondrial remodeling” in coronary heart disease
... for mitochondrial fusion and ...through fusion (left) and fission (right) to maintain cellular ...mitochondrial fusion. Mfn1 and Mfn2 locate in the outer mitochondrial membrane ...
12
Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex
... increased mitochondrial fragmentation [12, ...rupted mitochondrial fusion and AD-related deficits in the brain areas affected by AD, we utilized a genetic ap- proach by crossing the Mfn2 conditional ...
15
Regulation of mitochondrial dynamics in adipose tissue
... of mitochondrial fission may be compensated by an equivalent upregulation of expres- sion of the markers of mitochondrial ...in mitochondrial abundance may not necessarily indicate the full extent of ...
291
<p>Antitumor Actions of Intratumoral Delivery of Membrane-Fused Mitochondria in a Mouse Model of Triple-Negative Breast Cancers</p>
... the mitochondrial network was only found in solid tumors treated with P-Mito, and mitochondrial dynamics were concomitantly remodeled through increases in mitochondrial fusion proteins ...
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Orgler, Christina (2019): The potential to identify and explore innovative anticancer targets by using the natural products Vioprolide A and Lagunamide A. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... targeting mitochondrial dynamics Mitochondria are extremely dynamic organelles that constantly fuse and ...the mitochondrial network undergoes moderate fission and fusion, in order to fill the ...
95
Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis
... via mitochondrial quality control systems to maintain a healthy mitochondrial population within ...controlling mitochondrial morphology, previous studies demonstrated that mitochondrial ...
6
Hemagglutinin-neuraminidase and fusion proteins of virulent Newcastle disease virus cooperatively disturb fusion–fission homeostasis to enhance mitochondrial function by activating the unfolded protein response of endoplasmic reticulum and mitochondrial stress
... the fusion–fission homeostasis in response to intracel- lular and extracellular stresses ...of mitochondrial fusion–fission homeostasis is a com- plex and multistep cellular process, which must be ...
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