Mitochondrial Respiratory Chain
Pioglitazone leads to an inactivation and disassembly of complex I of the mitochondrial respiratory chain
... the mitochondrial respiratory chain and altered supercomplex ...(C) Mitochondrial complexes isolated from an untreated mouse and three mice treated with 10 mg/kg/day PGZ for 12 weeks were run ...
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Studies on the genetics and molecular pathogenesis of mitochondrial respiratory chain disorders
... Five mitochondrial respiratory chain complexes lying in the inner mitochondrial membrane are responsible for energy production by oxidative phosphorylation [Cooper and Clark ...of ...
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Coenzyme Q10 defects may be associated with a deficiency of Q10-independent mitochondrial respiratory chain complexes
... by mitochondrial respiratory chain (MRC) spectrophotometric analysis, then confirmed by direct meas‑ urement of CoQ 10 levels, is of critical importance to prevent irreversible damage in organs such ...
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HIBCH mutations can cause Leigh-like disease with combined deficiency of multiple mitochondrial respiratory chain enzymes and pyruvate dehydrogenase
... Multiple mitochondrial respiratory chain (RC) enzyme deficiencies can arise from a number of mechanisms, including defective maintenance or expression of mitochondrial ...multiple ...
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Mitochondrial respiratory chain dysfunction modulates metalloproteases 1, 3 and 13 in human normal chondrocytes in culture
... the mitochondrial respiratory chain (MRC) complexes II and III is reduced in human OA chondrocytes in culture compared to healthy chondrocytes ...the mitochondrial activity ...
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Idea on Holistic Medicine Based on the Electron Leak Pathways of Mitochondrial Respiratory Chain
... imperfect. Mitochondrial symbiosis is a landmark event in which life evolves from a single cell to a multicellular ...the mitochondrial respiratory chain reminds me to describe the function of ...
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Original Article Overexpression of GRIM-19, a mitochondrial respiratory chain complex I protein, suppresses hepatocellular carcinoma growth
... of mitochondrial respiratory chain complex I, which provides a link between the mitochon- drion and its electron transport chain and apoptotic cell death [7, ...with mitochondrial ...
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Superoxide Production by the Mitochondrial Respiratory Chain
... While Oi formation increases with oxygen concentration [both under normobaric or hyperbaric conditions (Boveris et al., 1973; Chance et al., 1978; Turrens et al., 1982b; Turrens et al., [r] ...
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Amyloid beta-peptide induced oxidative stress and mitochondrial respiratory chain damage: A mechanism for cell death in Alzheimer's disease
... causes mitochondrial damage, by elevating oxidative stress and/or increasing m itochondrial calcium ...f mitochondrial breakdown ...enhanced mitochondrial breakdown in vivo, the available data are ...
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CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain
... Homozygous deletion of chchd4 in mice, which is em- bryonic lethal, results in a decrease in whole CI expres- sion [28], and human CI deficiency which is fatal is associated with a cysteine mutation within the CI ...
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De novo CTBP1 variant is associated with decreased mitochondrial respiratory chain activities
... Council Mitochondrial Biology Unit ...United Mitochondrial Disease Foundation and the Lily Foundation and receives research support from the Wellcome Centre for Mitochondrial Research ...
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Decoding Warburg’s hypothesis: tumor-related mutations in the mitochondrial respiratory chain
... with mitochondrial encephalomyopathy [111], cybrids with one of these mutations were obtained by fusing enucleated fibroblasts from patients to one of these mitochondrial mutations with HeLa cells without ...
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Muscle Transcriptional Profile Based on Muscle Fiber, Mitochondrial Respiratory Activity, and Metabolic Enzymes
... the respiratory chain, hormones, and transcription fac- ...promotes mitochondrial bio- genesis, and stimulates coupled respiration ...of mitochondrial respiratory chain COXIV and ...
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A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity
... (a) Alignment of mammalian COQ7 N-terminal protein sequences (amino acids 1 to 42) using Clone Manager; HS, Homo sapiens; CL, Canis lupus familiaris; MM, Mus musculus; RN, Rattus norvegicus. Conserved residues are in red ...
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Deficiency of the Mitochondrial Electron Transport Chain in Muscle Does Not Cause Insulin Resistance
... long chain acyl-CoA dehydrogenase (LCAD) (a gift from Dan Kelly), peroxisome proliferator-activated receptor d coactivator-1a (PGC-1a), adenosine monophosphae kinase AMPK and phospho AMPK (Cell Signaling, Beverly, ...
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Mitochondrial oxygen affinity, respiratory flux control and excess capacity of cytochrome c oxidase
... (Fig. 1) to the maximum flux of the physiological system (Weibel et al. 1991). At steady state, oxygen fluxes through each step in the cascade are equal. Does the matching of capacities, therefore, imply that equal ...
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Patients with sepsis exhibit increased mitochondrial respiratory capacity in peripheral blood immune cells
... muscle tissue, PBICs have a much higher turnover, and, as immune cells, they go from quiescence to activity during the infectious process and are not subjected to the passivity usually imposed on muscle tissues in sepsis ...
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Inadequate food intake at high temperatures is related to depressed mitochondrial respiratory capacity
... outer mitochondrial membrane integrity (Kuznetsov et ...the respiratory control ...the mitochondrial membrane in the absence of phosphorylation, was induced by adding oligomycin (2 µg ml), an ...
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Porcine reproductive and respiratory syndrome virus triggers mitochondrial fission and mitophagy to attenuate apoptosis
... The mitochondrial dynamics and mitophagy play crucial roles in metabolism, cellular differentiation and neurodegeneration [28, ...of mitochondrial dynamics and mitophagy were broadly studied in the context ...
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Predominant Cerebellar Volume Loss as a Neuroradiologic Feature of Pediatric Respiratory Chain Defects
... oxidase deficiency, progressive cerebellar volume loss may be the first neuroradiologic feature observed. In retrospect, because some of the patients of our cohort were ascertained in childhood rather than in early ...
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