Mitochondrial uncoupling protein 3 (UCP3)
Absence of mitochondrial uncoupling protein 3: Effect on thymus and spleen in the fed and fasted mice
... fasting, UCP3 protein expression is increased in mitochondria isolated from the thymus, but not spleen mitochondria of 129 wild-type mice when compared to fed ...The UCP3 peptide antibody detects ...
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The Role of Mitochondrial Uncoupling Protein 3 in T Cell Function
... for 3 min using a microwave, until ...dye. 3 µL of the GeneRuler™ DNA Ladder Mix and 8 µL of samples were loaded onto the ...and Ucp3 genotyping are displayed in Appendix ...
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Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells
... increased UCP3 expression in- creases glucose ...overexpress UCP3 protein in muscle at levels ⬃ 20-fold normal have improved glucose homeostasis (41) and protection against hypergly- cemic-induced ...
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The role of uncoupling protein 3 in human physiology
... in UCP3 that is associated with a marked reduction in basal lipid oxidation rates and an increase in resting respiratory quotient in Gullah-speaking African Americans ...to mitochondrial func- tion since ...
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The Preservation of in vivo Phosphorylated and Activated Uncoupling Protein 3 (UCP3) in Isolated Skeletal Muscle Mitochondria following Administration of 3,4 Methylenedioxymethamphetamine (MDMA aka Ecstasy) to Rats/Mice
... muscle mitochondrial UCP3 is one of those proteins phosphorylated in vivo, on serine(s) and tyrosine(s) (but not threonine) following treatment of animals with MDMA (Figure ...4). UCP3 ...
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Increased uncoupling protein 2 and 3 mRNA expression during fasting in obese and lean humans
... characterized mitochondrial UCPs designated UCP2 and UCP3 are candidates to explain the proton leak ...the mitochondrial carrier family show much lower percentages of sequence ...conserved ...
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Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo
... the mitochondrial matrix lacks long-chain fatty-acyl-CoA synthetase, it is crucial for proper oxidation of long- chain fatty acids to enter the mitochondria through the carnitine-acyl-tranferase ...the ...
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Overexpression of uncoupling protein 3 in skeletal muscle protects against fat induced insulin resistance
... Human UCP3 expression at molecular mass 34,000 in the mixed gastrocnemius mitochondrial fraction of homo- zygous UCP3 transgenic mice, heterozygous UCP3 transgenic mice bred with B6CBAF1/J ...
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Insights into brown adipose tissue evolution and function from non model organisms
... and protein was investigated, demonstrating that no protein is translated in pigs (Hou et ...using UCP3 as an alternative uncoupling protein (Lin et ...to UCP3 as an uncoupler ...
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Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
... suggested that this system of thermogenesis can provide a defense against obesity. To test this idea, we created a transgenic mouse in which the fat-specific aP2 gene promoter directed Ucp expression in white fat and ...
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Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5
... mals were anesthetized using urethane (1 g/kg body weight, intraperitoneally). The body temperature was maintained at 37 ° C using a thermostated electric plate and was monitored by a rectal probe. Later, the head was ...
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Mitochondrial uncoupling protein 1 expression in thymocytes
... length sheep anti-mouse UCP 1 at 1:100, mouse anti-Thy-1 at 1:100, rabbit anti- mouse CIDEA at 1:50. Alexa 488 and Alexa 647 were used at a dilution of 1:1000 dilution and Cy3 and Cy5 at a dilution of 1:250. Altogether, ...
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Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase
... heterotrimeric protein with each of its three subunits (a, b, and c, respectively) encoded by different genes, giving rise to a large variety of heterotri- meric combinations in different ...by protein ...
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Unraveling Biochemical Pathways Affected by Mitochondrial Dysfunctions Using Metabolomic Approaches
... detected. Mitochondrial metabolites (and thus the molecular signatures of mitochondrial dysfunction) can remain undetected when these analyses are performed on ...and mitochondrial overload with ...
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Mechanisms of damage to the gastrointestinal tract from non steroidal anti inflammatory drugs
... An alternative approach is to reduce or prevent NSAID-induced small bowel damage with probiotics, although results from studies of probiotics have been incon- sistent. In a clinical trial, the probiotic VSL-3 ...
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Mitochondrial dysfunction induced by fatty acid ethyl esters, myocardial metabolites of ethanol
... the mitochondrial membrane, fatty acid ethyl esters may contribute to a potentially toxic shuttle for fatty acid with transport from physiological intracellular binding sites to the mitochondrial membrane; ...
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Genetic and epigenetic interactions in adaptive thermogenesis pathways in association with obesity from a Public Health Genomics perspective
... (adrB3), uncoupling protein 1 (ucP1), the transcription factors peroxisome proliferated activator receptor gamma (PParγ), peroxisome proliferated activator receptor gamma co-activator 1 alpha (Pgc1α), ...
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Mitochondrial uncoupling protein 1 overexpression increases yield in Nicotiana Tabacum under drought stress by improving source and sink metabolism
... Overexpression of plant mitochondrial uncoupling protein in transgenic tobacco increases tolerance to oxidative stress.. Activation and function of mitochondrial uncoupling protein in pl[r] ...
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Association Between Uncoupling Protein 3 Gene and Obesity-Related Phenotypes in the Québec Family Study
... Two other polymorphisms were studied: a valine to isoleucine substitution at amino acid 102 (V102I(G → A)) (18,19), and a C to T nucleotide tran- sition in tyrosine 210 codon (Y210Y(C → T)) (22). For both polymorphisms, ...
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Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet
... binding protein (SREBP)-1c, and fatty acid-binding protein 2 (aP2), were analyzed in white adipose tissue ...and uncoupling protein-2 (UCP2), involved in β -oxidation and thermogenesis, were ...
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