mitogen-activated protein kinase-2
Kinase Activity Profiling of Gram-Negative Pneumonia
... approach. Kinase activity arrays enable the analysis of 1,024 con- sensus sequences of protein kinase ...a kinase activity array on whole lung lysates, cellular kinase activities were ...
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“Docking Studies on Eupalitin-3-O-β-D-galactopyranoside as Potential Inhibitor of Cyprinus carpio (KOI CARP) MAPK/ERK Kinase 2 and Mitogen-Activated Protein Kinase (p38)” by Kader Asen Fathima, Chetancherry Somasundaram Parameswari, India.
... MAPK/ERK kinase 2 are: LYS98, LEU116, LEU119, CYS122, ASN123, ILE127, VAL128, GLY129, PHE130, ILE142, CYS143, MET144, LEU207, CYS208, ASP209, PHE210, GLY211, VAL212, SER213, LEU216, ILE217, ...enzyme ...
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Mitogen-Activated Protein Kinase Kinase 2, a Novel E2-Interacting Protein, Promotes the Growth of Classical Swine Fever Virus via Attenuation of the JAK-STAT Signaling Pathway
... viral protein synthesis. In addition, the biphasic activation of ERK1/2 has also been observed for coxsackievirus B3 (38), entero- virus 71 (EV71) (18), and herpes simplex virus 2 (HSV-2) ...
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A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases
... the kinase under investigation. The protein kinases of the mammalian genome can be divided into several groups ...the mitogen-activated protein kinases (MAPKs) are strongly implicated ...
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Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death
... Based on a clinically relevant animal model of brain stem death [6,9] in conjunction with toxicity elicited by the organophosphate insecticide mevinphos (3-(dimetho- xyphosphinyloxyl)-2-butenoic acid methyl ester ...
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Role of the stress activated protein kinases in endothelin induced cardiomyocyte hypertrophy
... stress-activated protein ki- nase (SAPK) family of mitogen-activated protein (MAP) ki- nases or another stress-response MAP kinase, p38, by over- expression of activated ...
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Enhanced expression of microtubule-associated protein 7 functioned as a contributor to cervical cancer cell migration and is predictive of adverse prognosis
... of mitogen‑activated protein kinase kinase (MEK) and extracellular signal‑regulated kinase (ERK) in Caski and HeLa cells, and overexpression of MAP7 increased their ...
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Modulation of Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 by Hepatitis C Virus Core Protein
... core protein purified from ...Core protein was verified with an anticore antibody ...panel). Protein expressions of Flag-tagged MAPKAPK3 and Myc-tagged core were verified by IB with an anti-Flag ...
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Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5)
... In order to evaluate the models’ ability to distinguish between real inhibitors and decoy substances, the three different models were docked both with the 90 decoy ligands and 10 inhibitors in a semi-flexible mode. Score ...
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Mitogen-Activated Protein Kinase Pathways and Fungal Pathogenesis
... Although C. albicans is a diploid fungus traditionally classi- fied as asexual, mating between genetically modified strains and a parasexual cycle have been observed. CEK2 (25) and several components of the CEK1 pathway, ...
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Supplementing L-isoleucine increases medium protein and alters the expression of genes and proteins involved in milk protein synthesis and energy metabolism in bovine mammary cells
... milk protein synthesis, using an immortalized bovine mammary epithelial (MAC-T) cell ...for protein synthesis for each amino acid was determined by measuring the cell, medium and total protein at 0, ...
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Original Article Lipoteichoic acid of Streptococcus sanguinis induces the expression of cyclooxygenase-2 via MAPK signaling pathways in H9c2 cells
... receptor 2 to transduce the LTA signal into the cytoplasm ...phospholipase/protein kinase C (PKC)/NF-κB cascade and the tyrosine kinase/phosphati- dylinositol 3-kinase (PI3K)/AKT/p38 ...
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Regulation of the mitogen activated protein kinase p44 ERK activity during anoxia/recovery in rainbow trout hypodermal fibroblasts
... serine/threonine protein phosphatase 1 (PP1) and/or PP2A as the downstream effector of p38 MAPK ...the kinase Raf-1 in vivo (Abraham et ...scaffold protein kinase suppressor of Ras (KSR) (Ory ...
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PKM2, function and expression and regulation
... mitogen activated protein kinase; MAPKK5/MEK5: mitogen activated protein kinase kinase 5; MG: methylglyoxal; MLC2: myosin light chain 2; MiR/miRNA: ...
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From mouth to macrophage: mechanisms of innate immune subversion by Mycobacterium avium subsp. paratuberculosis
... signal-regulating kinase 1; AP-1-Jun: Activator protein-1-JUN; ATP: Adenosine triphosphate; BCG: Bacillus Calmette-Guerin; Bcl-2: B-cell lymphoma 2; CARD15: Caspase associated recruitment ...
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From basic research to clinical development of MEK1/2 inhibitors for cancer therapy
... Given the central role of the Raf-MEK-ERK1/2 signaling pathway in cell proliferation and survival signaling, it is therefore not surprising that alterations in this pathway are highly prevalent in human cancer. ...
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Screening of potential diagnostic markers and therapeutic targets against colorectal cancer
... MBD2b protein-sepharose-4B column was used to enrich the methylated DNA frag- ...log 2 fold change (FC) in each patient to screen the differentially methylated DNA ...log 2 FC value $4 or #−4 were ...
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Phosphoproteomic Characterization Of Glycogen Synthase Kinase-3
... ribonucleoproteins (snRNPs) and a number of associated proteins (Maniatis and Tasic, 2002). Splicing is catalyzed by a series of sequential steps that bring the 5’ and 3’ ends of splice sites together to from an intron ...
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MAP3K1 May be a Promising Susceptibility Gene for Type 2 Diabetes Mellitus in an Iranian Population
... The study population was composed of 342 unrelated Iranian individuals, including 177 patients with T2DM and 165 unrelated healthy control subjects who were defined based on the WHO criteria and matched for age and ...
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English_unc_0153D_14626.pdf
... diffusion 80 . From these experiments it is evident that Hog1 is activated processively and phosphorylated maximally in response to low doses of osmostress. In particular, we observed full activation of Hog1 ...
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