Mixed chimerism
Mixed chimerism induced without lethal conditioning prevents T cell– and anti Galα1,3Gal–mediated graft rejection
... in mixed chimeras were free from all types of rejection, indicating the presence of tolerance at the level of both T and B ...of mixed chimerism can simultaneously prevent both T cell– and ...
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Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large animal model
... stable mixed hematopoietic cell chimerism and donor-specific tolerance can be established in miniature swine, using a relatively mild, non-myeloablative preparative ...stable mixed chimerism, ...
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Induced regulatory T cells in allograft tolerance via transient mixed chimerism
... This study, which demonstrates decreased CD8 responses in tolerant NHPs, despite persistent CD4 anti-donor responses due to donor-specific expansion of Tregs, provides support for the hypothesis that specific induction ...
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Mixed chimerism and tolerance without whole body irradiation in a large animal model
... Induction of tolerance as assessed by renal allografts. In two of these long-term mixed chimerism animals (nos. 13101 and 13476), we tested induction of toler- ance by transplantation of an MHC ...
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Incomplete clonal deletion as prerequisite for tissue-specific minor antigen tolerization
... in mixed chimerism (40) or peripheral tolerance models (41), this is the first study employing a clinically relevant fully MHC- and minor antigen–mismatched strain ...
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Successful bone marrow transplantation in a patient with Diamond Blackfan anemia with co existing Duchenne muscular dystrophy: a case report
... Though this percentage of donor cells was small, the presence of these cells in the patient’s muscle tissue indicates the possibility of transdifferentiation of hema- topoietic donor stem cells to skeletal muscle ...
5
Prognostic utility of routine chimerism testing at 2 to 6 months after allogeneic hematopoietic cell transplantation.
... with mixed chimerism had a decreased risk of chronic GVHD after HCT for treatment of aplastic anemia, while Balon et ...complete chimerism within the first 3 months after HCT was associated with an ...
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Hematopoietic chimerism after allogeneic stem cell transplantation: a comparison of quantitative analysis by automated DNA sizing and fluorescent in situhybridization
... compartment. Chimerism also reflects response to treatment [3], since it correlates with the risk of malig- nancy ...with mixed chimerism have an increased risk of developing relapse or graft ...
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Lack of utility of chimerism studies obtained 2-3 months after myeloablative hematopoietic cell transplantation for ALL.
... PB chimerism studies have been recommended for children with ALL undergoing allogeneic transplantation to detect increasing mixed chimerism, allowing for early intervention with immunomodulatory ...
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Hematopoietic Stem Cell Transplantation in Hemophagocytic Lymphohistiocytosis: A Single-Center Report of 48 Patients
... Mixed chimerism ⱖ 50% was detected in 6 (43%), be- tween 20% and 50% in 7 (50%), and ⬍ 20% in 1 ...(6%). Chimerism was found to be stable over time in these 28 patients (data not ...a mixed ...
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The Relationship between STR-PCR Chimerism Analysis and Chronic GvHD following Hematopoietic Stem Cell Transplantation
... sex, chimerism, acute GvHD, chronic GvHD, survival and ...study, chimerism was divided into two categories: complete chimerism (more than 95% of hematopoietic cells post-transplant are of donor ...
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CD4 Donor Lymphocyte Infusion Can Cause Conversion of Chimerism Without GVHD by Inducing Immune Responses Targeting Minor Histocompatibility Antigens in HLA Class II
... Allogeneic stem cell transplantation (alloSCT) provides a potentially curative therapy for patients with a variety of hematologic malignancies. However, acute graft-vs.-host disease (GVHD) and treatment of GVHD remain ...
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Successful Hematopoietic Stem Cell Transplantation for Niemann-Pick Disease Type B
... on days 3, 6, 11, and 18. Her transplant complications included veno-occlusive disease and mild to moderate respiratory distress. After an initial engraftment that showed mixed chimerism (85% donor/15% ...
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A comparison of flow cytometry detection of minimal residual disease and chimerism kinetics in chronic lymphocytic leukemia patients after allogeneic hematopoietic stem cell transplantation
... donor chimerism (FDC) and one had mixed chimerism ...and chimerism in both PB and BM by using a mixed effect linear re- gression (p < ...with chimerism during the follow-up ...
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Optimizing peripheral blood stem cells transplantation outcome through amend relapse and graft failure: a review of current literature
... of prophylactic donor leukocyte infusions on mixed chimerism, graft- versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyelo[r] ...
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Dynamics of Graft Function Measured by DNA-Technology in a Patient with Severe Aplastic Anemia and Repeated Stem Cell Transplantation
... revealed mixed chimerism (Figure 1, phase 1), but peripheral blood counts continued to ...19. Chimerism analysis revealed increasing donor T-cell content and in parallel declining percentage of donor ...
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Automated detection of residual cells after sex-mismatched stem-cell transplantation – evidence for presence of disease-marker negative residual cells
... complete chimerism, in contrast a mixture of both donor and acceptor cells mixed ...chimerism. Chimerism analysis is done on these sex-mismatched transplants to monitor minimal residual ...
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Chimerism and allorecognition in the broadcast spawning coral Acropora millepora on the Great Barrier Reef
... ontogeny. Chimerism challenges many aspects of the purportedly accurate discrimination between self and non-self required for immunocompetence, and also challenges the notion of genetic uniqueness within ...
147
6029.pdf
... Alternatively, chimerism could result in genomic retargeting such that differences in transcriptional output would result from variation in the sites of chromatin ...of chimerism and cell lineage to ...
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Chimerism and allorecognition in the broadcast spawning coral Acropora millepora on the Great Barrier Reef
... Fig. 2.1. Schematic diagrams showing: A) experimental design for mixing gametes from different colonies (identified by numbers) to produce larvae that differed in kinship level (full siblings , half siblings , or non ...
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