Mixed lineage kinase (MLK)
Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis.
... identified mixed lineage kinase 3 (MLK3) as a putative NS5A interacting ...protein kinase that is a member of the MAPK kinase kinase (MAP3K) family and activates ...
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Pivotal Role of Receptor-Interacting Protein Kinase 1 and Mixed Lineage Kinase Domain-Like in Neuronal Cell Death Induced by the Human Neuroinvasive Coronavirus OC43
... protein kinase 1 (RIP1) and RIP3 interacting with each other ...of mixed lineage kinase domain-like (MLKL) and ultimately in cell death ...
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Genetic Analysis of Slipper/Mixed Lineage Kinase Reveals Requirements in Multiple Jun-N-Terminal Kinase-Dependent Morphogenetic Events During Drosophila Development
... is specific to Eiger overexpression because it is reversed by coexpression of an inverted-repeat Eiger transgene causing RNA interference in vivo (Figure 9B). Neither reducing the dosage of wild-type slpr genetically nor ...
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The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation
... MAPK kinase kinases (MAPKKKs) that function as bonafide serine/threonine kinases, although their catalytic domains have features of both serine/threonine and tyrosine ...the MLK family ...through ...
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Low expression of mixed lineage kinase domain-like protein is associated with poor prognosis in ovarian cancer patients
... Our study demonstrated that expression of a protein involved in necroptosis exhibits prognostic value in ovarian cancer patients, suggesting that necroptosis may play an important rol[r] ...
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Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis
... that URMC099 treatment exerts a direct inhibition of MLK3 downstream targets, we demonstrate signifi- cant reduction of the FFC diet–induced phosphorylation of the mitogen-activated prot[r] ...
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The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders
... URMC-099’s kinase se- lectivity using a kinome-wide scanMAX assay, which revealed that URMC-099 potently inhibits tens of kinases with > 99% inhibition at 1 μM ...
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Domain Specificity of MAP3K Family Members, MLK and Tak1, for JNK Signaling in Drosophila
... protein kinase (MAPK/SAPK) signaling ...MAPK kinase kinases (MAP3Ks) that activate Jun kinase (JNK) signaling ...the mixed lineage kinase, Slpr, and the TGF-b activated ...
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O-GlcNAc transferase suppresses necroptosis and liver fibrosis
... Worldwide, over a billion people suffer from chronic liver diseases, which often lead to fibrosis and then cirrhosis. Treatments for fibrosis remain experimental, in part because no unifying mechanism has been identified ...
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Necroptosis: a new link between cell death and inflammation
... DAMPs: damage associated molecular patterns; MLKL: mixed lineage kinase domain-like protein; TNF: tumour necrosis factor; TNFR: tumour necrosis factor receptor; cIAP: calf intestinal al[r] ...
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JNK-signaling: A multiplexing hub in programmed cell death
... Protein Kinase or RIP3. Activated RIP3 and the downstream pseudokinase Mixed-Lineage kinase domain Like (MLKL) oligomers form a necrosome complex and translocate to mitochondria-associated ...
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Conditional knockout of TGF-βRII /Smad2 signals protects against acute renal injury by alleviating cell necroptosis, apoptosis and inflammation
... chemotactic protein-1; MLKL: mixed lineage kinase domain like pseudokinase; RIPK: Receptor- interacting serine/threonine-protein kinase; S2FF: Smad2 flox/flox mouse; S2 KspCre: cond[r] ...
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Whole genome sequencing reveals high-resolution epidemiological links between clinical and environmental Klebsiella pneumoniae
... The detection of carbapenem-resistant isolates in pre- treated hospital wastewater reiterates the importance of the treatment of hospital wastewater prior to release into the environment [40, 41]. Our study also ...
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Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus.
... cells born at the junction of the neural and non-neural ectoderm. This lineage has contributed to our under- standing of cellular behaviours, such as contact inhibition of locomotion 1 . It is the origin of many ...
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Montelukast versus inhaled corticosteroids in the management of pediatric mild persistent asthma
... When asthma control days (ACDs) were used as an outcome, higher baseline eNO levels, greater salbutamol use, and more positive aeroallergen skin test responses, in addition to fewer ACDs at baseline, predicted more ACDs ...
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Musashi2 sustains the mixed lineage leukemia–driven stem cell regulatory program
... cells exhibit a dysregulated developmental program as the result of genetic and epigenetic alterations. Overexpression of the RNA-binding protein Musashi2 (MSI2) has been previously shown to predict poor survival in ...
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Modern social structure and social organization in Upper Mandailing, Sumatra
... X Chapter 6 : THE LINEAGE SYSTEM Sibling groups The ompu Property and the lineage Jural unity and the lineage The minimal lineage as the paradigm of social relations within the descent g[r] ...
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Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation
... Janus kinase/signal transducer and activator of tran- scription 1 (JAK/STAT) pathway is triggered, leading to pIV accumulation of the requisite transcription factors, and the initiation of CIITA transcription ...
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A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis
... with mixed-lineage leukemia (MLL) and co-occupied the HOXA9 promoter region with MLL in AML leuke- mic cells, which suggests that a SALL4/MLL pathway may control HOXA9 ...
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Epidemiology of Acute Lymphoblastic Leukemia with reference to prevalence and genetics
... Mixed phenotype is rare 4% in ambiguous lineage co-exist with two separate blast cells T-or B-cells acute lymphoblastic leukemia either myeloid or monocytic blast cells [r] ...
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