mixed solvency
Solubility Enhancement of Candesartan Cilexetil by Mixed Solvency Approach
... Solubility is measured in terms of the maximum mass or volume of solute that will dissolved in a given mass or volume of solvent at a particular temperature and at equilibrium. 3 Solubility is an important parameter to ...
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Formulation development and evaluation of diclofenac sodium injection using benzyl alcohol (co-solvent), mixed solvency concept
... then propylene glycol based injection. At the end, we studied the stability, toxicity, pyrogenicity and isotonicity of the formulated injection. Conclusion: From the various formulation studied, it was found that benzyl ...
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“SOLID AS SOLVENT” SPECTROPHOTOMETRIC ESTIMATION OF SATRANIDAZOLE TABLETS USING SOLIDS (EUTECTIC LIQUID OF PHENOL AND LIGNOCAINE HYDROCHLORIDE) AS SOLUBILIZING AGENTS (MIXED SOLVENCY CONCEPT)
... 24. Maheshwari RK, Putliwala M, Padiyar A. Novel approach for spectrophotometric estimation of naproxen in tablet dosage form using solids (eutectic liquid of phenol and niacenamide) as solubilizing agent (mixed ...
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SIMULTANEOUS ESTIMATION OF NORFLOXACIN AND TINIDAZOLE IN SOLID DOSAGE FORM BY U V SPECTROPHOTOMETRY USING MIXED SOLVENCY CONCEPT
... In present research work a new simple, specific, precise, accurate, robust and economical UV-Spectrophotometric method for simultaneous estimation of norfloxacin and tinidazole in tablet dosage form using mixed ...
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SIMULTANEOUS ESTIMATION OF OFLOXACIN AND ORNIDAZOLE IN SOLID DOSAGE FORM BY U V SPECTROPHOTOMETRY USING MIXED SOLVENCY CONCEPT
... The present research work also provides an ecofriendly method for simultaneous estimation of ofloxacin and ornidazole in solid dosage form by UV Spectrophotometry by using mixed solvency concept. Ofloxacin ...
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NOVEL APPLICATION OF MIXED SOLVENCY CONCEPT IN THE DEVELOPMENT OF FAST DISSOLVING SOLID DISPERSION OF POORLY WATER SOLUBLE DRUG, TORSEMIDE AND ITS EVALUATIONS
... From all the above studies, it was concluded that the approach of mixed solvency is novel, safer and user friendly. It also eliminates the problem of toxicity associated with the use of toxic organic ...
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Formulation development of topical solutions of poorly water-soluble drug indomethacin employing novel application of mixed solvency concept and their evaluation
... of mixed solvency concept has been employed in the present research work to develop the topical solution formulations of poorly water-soluble drug indomethacin (as a model ...as mixed solvent systems ...
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Formulation and development of fast dissolving oral film of a poorly soluble drug, frusemide with improved drug loading using mixed solvency concept and its evaluation
... of mixed solvency concept to formulate and develop a fast dissolving oral film of furosemide with improved drug ...of mixed blends, different aqueous blends were prepared employing solubilizers from ...
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''Eco-friendly extraction using solids'' - A novel application of mixed solvency concept
... As per the mixed solvency concept (proposed by Dr. R.K. Maheshwari), each and every substance present on the earth has got solubilizing property i.e. all the liquids, gases and solids possess solubilizing ...
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NOVEL APPROACH FOR SPECTROPHOTOMETRIC ESTIMATION OF PIROXICAM IN TABLET DOSAGE FORM USING CO MELT OF SODIUM ACETATE TRIHYDRATE AND RESORCINOL AS ECOFRIENDLY SOLVENT (MIXED SOLVENCY CONCEPT)
... The pollution and toxicity caused by most of the organic solvents is a big challenge. The researchers are doing much work to give eco- friendly solutions for this challenge. Maheshwari has given a nice concept, known as ...
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Formulation and development of vaginal films of poorly water soluble drug, metronidazole, using mixed solvency concept and their evaluations
... of mixed solvency concept to increase solubility of poorly water soluble drug, ...of mixed solvency concept is novel, safe, cost-effective and user ...
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DEVELOPMENT AND VLAIDATION OF SIMPLE UVSPECTROPHOTOMETRIC METHOD OF QUANTIZATION OF NIFEDIPINE IN SOLID DOSAGE FORMULATION USING MIXED SOLVENCY CONCEPT
... By application of this concept, innumerable solvent system can be developed. Maheshwari [1,6] is one of the opinions that each substance possesses solubilizing power. He has given several ecofriendly methods in the area ...
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NOVEL PHARMACEUTICAL APPLICATION OF MIXED SOLVENCY IN THE FORMULATION DEVELOPMENT OF SYRUPS (LIQUID ORAL SOLUTIONS) OF POORLY WATER-SOLUBLE DRUGS
... of mixed-solvency has been explored to develop liquid oral solutions (syrups) of poorly water soluble drugs Naproxen and Furosemide, to give quick onset of action and better bioavailability (in comparison ...
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Spectrophotometric Estimation of Acyclovir by a Novel Mixed Solvency Solubilisation Concept
... novel mixed solvency solubilisation phenomenon was developed to study the effect on solubility of poorly water soluble ...this mixed cosolvency technique were reported to study the improvement in ...
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FORMULATION DEVELOPMENT AND EVALUATIONS OF AN AQUEOUS INJECTION OF GATIFLOXACIN BY NOVEL MIXED SOLVENCY TECHNIQUE
... Maheshwari [1-4] proposed the concept of mixed solvency. He is of the opinion that all substances whether liquids, gases or solids possess solubilizing power and hence concentrated aqueous solutions ...
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FORMULATION AND EVALUATION OF SULPHASALAZINE INJECTION MADE BY MIXED SOLVENCY SOLUBILIZATION TECHNIQUE
... Preparation of calibration curve in different medium For preparation of calibration curve in de-mineralized water, blends, buffers of pH 7.4, 8.0, 9.0 (Physiological pH and pH range of blends) and different mixed ...
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NEW SPECTROPHOTOMETRIC ESTIMATION OF NORFLOXACIN IN THE TABLETS USING MIXED SOLVENCY APPROACH
... Organic solvents are most frequently employed in spectrophotometric analyses. They may be sources of pollution. Some of them may be toxic while others may be costlier. Volatility may be a source of inaccuracy in ...
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Title: EFFECT OF DIFFERENT TABLET DISNTEGRANTS ON PROCHLORPERAZINE MALEATE TABLETS Author: Kuldeep Ganju*, Eisha Ganju Keyword: Prochlorperazine maleate, disintegrant, magnesium stearatePage No: 252-254Abstract: The study is performed to determine the effect of selected superdisintegrants, Primellose and Primojel, on the Disintegration time (DT) of tablets of Prochlorperazine maleate. The molecule is an anti emetic and a high rate of disintegration would give faster pharmacological effect. 1%, 2% and 4% concentrations of the selected disintegrants were added and all other composites were kept constant. 4% Primellose gave the best result with a DT of 1 min 45 s. Key Words: Prochlorperazine maleate, disintegrant, magnesium stearate Download PDF
... the mixed solvency has been employed in the present research work to develop the oral solution (syrup) formulations of poorly water soluble drugs aceclofenac (as model ...as mixed solvent system) ...
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MIXED CO-SOLVENCY CONCEPT: A PROMISING TOOL TO ENHANCE SOLUBILITY OF POOR SOLUBLE DRUG ACECLOFENAC
... The present work proposes hydrotropy as a type of co-solvency method to increase the solubility of Aceclofenac as the drug candidate due to its poor solubility. Aqueous solutions containing small quantities of ...
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FORMUATION AND EVALUATION OF DRY SUSPENSION OF ORNIDAZOLE AS PARENTERALS
... of mixed solvency concept in the formulation of dry dosage forms of poorly soluble drug and to minimize the toxic effects of solubilizers by reducing the concentration of individual solubilizer (used for ...
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