molecular heterogeneity
Molecular heterogeneity of a lymphocyte glycoprotein in immunodeficient patients
... Previous evaluation of lymphocytes taken from patients with Wiskott-Aldrich syndrome (WAS) and other X-linked immunodeficiencies has revealed deficiencies of a lymphocyte sialoglycoprotein with a relative ...
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Molecular heterogeneity in adjacent cells in triple-negative breast cancer
... intratumoral molecular heterogeneity in cancer markers with differences from polymerase chain reaction marker ...cell heterogeneity was recognized in adjacent cells examined with panels of ten ...
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Global gene expression profiling of oral cavity cancers suggests molecular heterogeneity within anatomic subsites
... the molecular complexity of this malignancy ...on molecular differences between OSCC and normal mucosa, but we compared gene expression profiles of OSCC samples from different anatomic ...that ...
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Molecular heterogeneity assessment by next-generation sequencing and response to gefitinib of EGFR mutant advanced lung adenocarcinoma
... Cancer molecular heterogeneity might explain the variable response of EGFR mutant lung adenocarcinomas to tyrosine kinase inhibitors ...(ACMs) molecular heterogeneity assessment using NGS ...
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Subgroup analysis reveals molecular heterogeneity and provides potential precise treatment for pancreatic cancers
... between molecular heterogeneity and clinical features of pancreatic cancer remains ...specific molecular characteristics and potential therapeutic ...optimal molecular subgroups in pancreatic ...
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Molecular heterogeneity in malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1
... lecular heterogeneity to be assessed more ...of molecular heterogeneity ...intra-tumoral molecular hetero- geneity could be related in some way to the grade of tumor, at least for those tumor ...
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Differentiation and molecular heterogeneity of inhibitory and excitatory neurons associated with midbrain dopaminergic nuclei
... and molecular heterogeneity of D-GABA neurons are poorly ...unique molecular markers, which correlate with their embryonic origins and anatomical locations ...
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Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas
... discover molecular heterogeneity of potential clinical and biological relevance among PFA ependymomas, and DNA methylation profiling yielded two subgroups and nine ...
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Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display
... their molecular diversity. We have studied organ-specific molecular differences of the endothelium in various tissues by using in vivo screening of peptide libraries expressed on the surface of a ...
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Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell lines
... Methods: We used 12 reduction mammoplasty tissues, 15 primary breast cancer tissues, and 20 human breast epithelial cell lines (16 cancer lines, 4 normal lines) to perform flow cytometry for CD44, CD24, epithelial cell ...
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Molecular heterogeneity of large-conductance calcium-activated potassium channels in canine intracardiac ganglia
... our molecular results suggest that BK chan- nels expressed in canine ICG are probably composed of BKα bearing more than one splice variant plus β4 and/or ...the molecular evidence presented ...
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Purine Nucleoside Phosphorylase Deficiency: EVIDENCE FOR MOLECULAR HETEROGENEITY IN TWO FAMILIES WITH ENZYME DEFICIENT MEMBERS
... The mother of the patients had one-half normal enzyme activity, 11% irm attributable to her variant protein, and a normal electrophoretic pattern.. The father had less than one-half norm[r] ...
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Type 1 hereditary tyrosinemia Evidence for molecular heterogeneity and identification of a causal mutation in a French Canadian patient
... several molecular levels including mRNA, immunoreactive material (IRM), and enzymatic ...various molecular phenotypes suggest that this disorder may be caused by a variety of FAH ...the molecular ...
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Nature of the molecular heterogeneity of human leukocyte interferon.
... Having established distinct differences in both the hydrophobicity and the ionic binding properties of the two components of human leukocyte interferon, we then determined, by molecular [r] ...
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Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations
... stantial heterogeneity in duration of the disease, degree of brain atrophy, neuronal loss, cortical and leptomeningeal vascular amyloidosis and basic type, number and distri- bution of amyloid ...
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Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics
... aberrations, thereby focusing functional studies on discrete genomic lesions and leading to the fi rst implication of somatic microRNA disruption in cancer. Next-generation sequencing (NGS) has further transformed our ...
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Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis Evidence for molecular heterogeneity and extensive molecular changes in disease
... Abbreviations used in this paper: CS, chondroitin sulfate; AdiC4S-s, disaccharide chrondroitin 4-sulfate stubs attached to core protein; AdiC6S-s, disaccharide chondroitin 6-sulfate stub[r] ...
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Single cell RNA sequencing to dissect the molecular heterogeneity in lupus nephritis
... the heterogeneity of tumor cells suggested potentially more effective therapeutic targeting approaches specifically directed at pathogenic tumor lineages (13, ...the heterogeneity of the disease; and ...
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Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser captured glomeruli
... of heterogeneity between lupus kidney biopsies in the increased expression of four main gene clusters, with each gene cluster reflecting the contribution of different pathways relevant to glomerular ...
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Heterogeneity revealed by integrated genomic analysis uncovers a molecular switch in malignant uveal melanoma
... the molecular etiology of prognostic ...the heterogeneity of UM. Cellular heterogeneity provides an insight into the micro environment of UM while detailed molecular heterogeneity is ...
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