Molecular Modelling for Platinum–DNA Interactions
Guanidine platinum(II) complexes: synthesis, in vitro antitumor activity, and DNA interactions
... on DNA of trans-6 are discrepant from those of neutral trans-congeners (trans- 1,3), raising the question whether this compound acts by a different ...bonding interactions when approaching DNA, which ...
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Multifaceted studies of the DNA interactions and in vitro cytotoxicity of anticancer polyaromatic platinum(II) complexes
... between DNA affinity and cytotoxicity was observed for complexes 3–6; 4 and 5 were the most and least effective in both areas, respectively, while 3 and 6 were approximately equal in both DNA affinity and ...
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MOLECULAR MODELLING OF SINGLE WALLED CARBON NANOTUBE WITH SINGLE STRAND DNA
... strand DNA. This procedure was initiated by situating single strand DNA chains close to the nanotube surface but perpendicularly or at an angle to their long CNT ...strand DNA could coil tightly ...
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Cyclic Voltammetry and Molecular Docking Study of the Interactions of Two Derivatives of 5-fluorouracil with DNA
... is the maximum difference of the oxidation peak current; and [drug] represents the concentration of the drug. As a result, the binding constant (K) are 2.33×10 3 L·mol -1 and 1.45 ×10 3 L·mol -1 for O and M, ...
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MOLECULAR INTERACTIONS OF NICOTINE AND THE NITROGENOUS BASES OF DNA AND RNA CALCULATED BY IMPROVED QUANTUM METHODS
... 9. Balsevich, G., Poon, A., & Wilking, J. A. The effects of pre-and pos-natal nicotine exposure and genetic background on the striatum and bhavioral phenotypes in mouse. Behavioral Brain Research, 2014; 266: 7-18. 10. ...
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Interactions of Platinum-Based Cytostatics with Metallothionein Revealed by Electrochemistry
... effects. Platinum-based drugs have significant antitumor activity caused particularly by the crosslinking of DNA and formation of DNA adducts with subsequent triggering the apoptosis leading to cell ...
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Interactions of DNA with a new Platinum(IV) Azide Dipyridine complex activated by UVA and visible light : relationship to toxicity in tumor cells
... nuclear DNA under conditions in which it is toxic to tumor ...the DNA adducts, including conformational alterations, induced by photoactivated 1 are distinctly different from those produced in DNA by ...
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Portal-Large Terminase Interactions of the Bacteriophage T4 DNA Packaging Machine Implicate a Molecular Lever Mechanism for Coupling ATPase to DNA Translocation
... seen. DNA sequencing showed that the normal-size plaques are true revertants, changing Q to D, whereas the slightly smaller plaques have a second site mutation while retaining the original D331Q ...
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Modelling Biomolecules: Studies on P-Type ATPases, DNA-Ligand Interactions and π-π Networks in Proteins
... ATPases, DNA-Ligand Interactions and π-π Networks in Proteins” comprises of seven ...as molecular dynamics, homology modeling, structure and analogue based drug design tools, quantum mechanics, ...
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Selective Interactions Between 5-fluorouracil Prodrug Enantiomers and DNA Investigated with Voltammetry and Molecular Docking Simulation
... the DNA were removed from the original ...and DNA were added along with Gasteiger charges and polar hydrogen atoms using AutoDockTools (ADT) version ...the molecular docking via the LGA using default ...
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MOLECULAR MODELLING AND MOLECULAR DOCKING STUDIES OF CYP450 INHIBITORS
... and molecular docking studies were performed to explore structural features and binding mechanism of existing drugs as cytochrome P450 4A11 inhibitors, and to construct a model for designing new cytochrome P450 ...
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Supramolecular ordering through axial interactions in mono and mixed valent metellomesogenic systems of platinum(II) and platinum(IV)
... the molecular alloy of PtL 16 Cl 2 /PtL 16 Cl 4 , which had been quenched with liquid nitrogen after self-assembly to preserve the supramolecular ordering of the mesophase, showed quenching of the luminescence ...
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Using protein design algorithms to understand the molecular basis of disease caused by protein–DNA interactions: the Pax6 example
... protein–DNA interactions was demonstrated by showing that high levels of accuracy can be achieved for mutations affecting these ...mental DNA-binding ...the molecular basis of diseases and ...
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Using protein design algorithms to understand the molecular basis of disease caused by protein-DNA interactions: the Pax6 example
... protein–DNA interactions was demonstrated by showing that high levels of accuracy can be achieved for mutations affecting these ...mental DNA-binding ...the molecular basis of diseases and ...
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LETTERS. DNA primase acts as a molecular brake in DNA replication
... DNA interaction. This leaves the possibility that ribonucleotide condensation by the primase results in an allosteric regulation of helicase activity through protein–protein interactions. The replica- tion ...
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Molecular Interactions
... INACTIV E PROTEIN ALLOSTERIC INHIBITION Allosteri c inhibitor Binding site ACTIVE PROTEI N Ligand Ligand.. Physical Factors[r] ...
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Molecular Interactions
... a USC Information Sciences Institute, 4676 Admiralty Way, Suite 1001, Marina del Rey CA 90292, United States of America Abstract. Scientific figures, captions and accompanying text provide a valuable resource that ...
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Interactions of Ammonia with Platinum and Ruthenium Surfaces
... the calculated rates between 0.3 and 0.6 torr are approximately 2 orders of magnitude lower than the measured rates. one immediately suspects a possible variation in on[r] ...
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The interactions of basic proteins and DNA
... Melting studies of NaCl and NaC104 extracted nucleoprotein also s_uggest that the latter salt extracts histones at lower concentrations. the sedimentation studies of[r] ...
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Modelling of Battery Electrolyte Interactions
... I thank my supervisor Patrik Johansson for giving me the freedom and resources to pursue my ideas as well as giving me the opportunity to work on several interesting projects. To all past and present members of KMF, ...
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