Monkeypox virus
Identification of Wild-Derived Inbred Mouse Strains Highly Susceptible to Monkeypox Virus Infection for Use as Small Animal Models
... Monkeypox virus (MPXV), a member of the orthopoxvirus genus of the Chordopoxvirinae subfamily of the Poxviridae, was isolated in 1958 from lesions in a cynomolgous monkey that had been imported from Africa ...
9
The effect of volume of interest definition on quantification of lymph node immune response to a monkeypox virus infection assessed by 18F-FDG-PET
... Assessment of cell glucose metabolism by 2-deoxy-2- [ 18 F]fluoro-D-glucose ( 18 F-FDG) and positron emission tomography (PET) is a powerful supplement to conven- tional studies of viral infection in animal models to ...
12
Assessment of the Protective Effect of Imvamune and Acam2000 Vaccines against Aerosolized Monkeypox Virus in Cynomolgus Macaques
... Monkeypox virus plaque assay. During the course of the study, EDTA-treated blood and throat swabs were collected and frozen at ⫺ 80°C and, at necropsy, tissues were collected and snap-frozen in liquid ...
11
Effective Antiviral Treatment of Systemic Orthopoxvirus Disease: ST-246 Treatment of Prairie Dogs Infected with Monkeypox Virus
... Variola virus (VARV), the causative agent of smallpox, remains a bioterror agent of ...concern. Monkeypox virus (MPXV) is en- demic to regions of Africa and caused epidemic human disease in the ...
12
[18F]-Fluorodeoxyglucose Uptake in Lymphoid Tissue Serves as a Predictor of Disease Outcome in the Nonhuman Primate Model of Monkeypox Virus Infection
... Standard characterization of monkeypox in nonhuman primates. The experi- mental design of this monkeypox virus (MPXV) intravenous (IV) challenge study and treatment with CDV is shown in Table 1. ...
13
Gene expression profiling of monkeypox virus infected cells reveals novel interfaces for host virus interactions
... Monkeypox virus (MPV) is a zoonotic Orthopoxvirus and a potential biothreat agent that causes human disease with varying morbidity and ...and virus-targeted host networks during infection is ...
19
A Preliminary Assessment of Silver Nanoparticle Inhibition of Monkeypox Virus Plaque Formation
... Abstract The use of nanotechnology and nanomaterials in medical research is growing. Silver-containing nano- particles have previously demonstrated antimicrobial efficacy against bacteria and viral particles. This pre- ...
5
Sequence of Pathogenic Events in Cynomolgus Macaques Infected with Aerosolized Monkeypox Virus
... PFU monkeypox virus in cynomolgus macaques. Monkeypox virus vDNA was detected in the lungs 2 days postinfection, and by day 4 the virus was detected in the throat, tonsil, and ...
10
Humoral Immunity to Smallpox Vaccines and Monkeypox Virus Challenge: Proteomic Assessment and Clinical Correlations
... in virus dissemination in natural infection (55) and typical vaccine strains produce only a single localized ...with monkeypox virus infec- ...
12
A Novel Respiratory Model of Infection with Monkeypox Virus in Cynomolgus Macaques
... with monkeypox virus, followed by systemic ...intratracheal monkeypox virus infection in animal 1 (low-dose group) on day 12 ...vaccinia virus; hematoxylin ...
12
Evasion of the Innate Immune Type I Interferon System by Monkeypox Virus
... vaccinia virus (VACV) E3 protein has been shown to be important for blocking activation of the cellular innate im- mune system and allowing viral replication to occur ...the monkeypox virus (MPXV) ...
11
Modified Vaccinia Virus Ankara Protects Macaques against Respiratory Challenge with Monkeypox Virus
... Variola virus, the etiological agent of smallpox, is now ranked high on the list of biological agents that may be used as a bioweapon (9) because infection with this virus results in approximately 30% ...
7
Monkeypox Virus Host Factor Screen Using Haploid Cells Identifies Essential Role of GARP Complex in Extracellular Virus Formation
... ABSTRACT Monkeypox virus (MPXV) is a human pathogen that is a member of the Orthopoxvirus genus, which includes Vaccinia virus and Variola virus (the causative agent of ...Human ...
16
Case Report Pathogenesis of fulminant monkeypox with bacterial sepsis after experimental infection with West African monkeypox virus in a cynomolgus monkey
... human monkeypox, which causes systemic and fulminant infections, is not ...fulminant monkeypox with bacterial sepsis after experimental infection with monkeypox virus in a cynomolgus monkey ...
12
Comparative Analysis of Monkeypox Virus Infection of Cynomolgus Macaques by the Intravenous or Intrabronchial Inoculation Route
... Monkeypox virus (MPXV) is a member of the genus Or- thopoxvirus, which includes variola (VARV), cowpox, vaccinia, and camelpox ...variola virus infections due to the prevalence of variola ...
14
A Mouse Model of Lethal Infection for Evaluating Prophylactics and Therapeutics against Monkeypox Virus
... variola virus (VARV) and monkeypox virus (MPXV) are considered to have significant potential to become bioterror agents (36, ...mousepox/ectromelia virus (ECTV) model ...such virus that ...
12
Lethal Monkeypox Virus Infection of CAST/EiJ Mice Is Associated with a Deficient Gamma Interferon Response
... Monkeypox virus (MPXV) is endemic in Africa, where it causes disease in humans resembling ...compared virus dissemination and induced cytokine production in CAST/EiJ mice to those in the resistant ...
8
Expansion, Reexpansion, and Recall-Like Expansion of Vγ2Vδ2 T Cells in Smallpox Vaccination and Monkeypox Virus Infection
... vaccinia virus vaccination and MPV ...vaccinia virus-vaccinated (left) and naïve (right) ...vaccinia virus- vaccinated (left) and naïve (right) ...vaccinia virus/MPV loads and increases in ...
7
Inhibition of Monkeypox virus replication by RNA interference
... glutamine, 10% of heat-inactivated fetal bovine serum (FBS), 10 mg/L Gentamycin, 250 μg/L Fungizone, and buffered with 10 mM HEPES [46]. Viral titers were deter- mined by the plaque assay as described in [29]. Briefly, ...
10
Deletion of the Monkeypox Virus Inhibitor of Complement Enzymes Locus Impacts the Adaptive Immune Response to Monkeypox Virus in a Nonhuman Primate Model of Infection
... knockout virus using standard recombination ...vaccinia virus (VV) 7,500-molecular- weight ...recombinant virus in culture ...resulting virus culture, and an EGFP-positive plaque was ...
16