monosodium urate crystals
Apolipoprotein (apo) E inhibits the capacity of monosodium urate crystals to stimulate neutrophils Characterization of intraarticular apo E and demonstration of apo E binding to urate crystals in vivo
... of monosodium urate crystals to stimulate leukocytes could regulate gouty ...to urate crystals and suppress crystal-neutrophil ...that urate crystals, coated with apo E of ...
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Immunoglobulin G independent activation of the classical complement pathway by monosodium urate crystals
... of monosodium urate crystals reduced the CH50 of 1 ml of human serum by 57% after 30 min at 37 degrees ...when urate crystals were incubated with isolated precursor C1, and required the ...
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Monosodium urate crystals reduce osteocyte viability and indirectly promote a shift in osteocyte function towards a proinflammatory and proresorptive state
... MSU crystals did not directly alter MLO-Y4 gene ex- pression in our 3D in-vitro cell culture model and, while direct interaction of MSU crystals with cells in the dee- per layers of the gels may have been ...
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MyD88 dependent IL 1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals
... MSU crystals were prepared by first dissolving uric acid (5 mg/ml) in ...large crystals formed during the first 48 hours were removed by centrifugation, and the supernatant uric acid solution was incubated ...
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Monosodium urate crystals induce oxidative stress in human synoviocytes
... MSU crystals induce by currently unknown mechanisms ...MSU crystals in an in vitro model of crystal-induced ...MSU crystals in human-derived synovial membrane (SM) ...MSU crystals trigger an ...
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Release of platelet constituents by monosodium urate crystals
... the monosodium urate crystal, is described ...to urate crystals proceeded in two phases: A secretory phase involved the rapid active release of serotonin, ATP, and ADP with little loss of ...
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Lipoproteins containing apoprotein B are a major regulator of neutrophil responses to monosodium urate crystals
... intraarticular urate crystals is known to be variable in gouty ...to urate crystals exposed to ...of crystals exposed to lipoprotein-depleted ...inhibited urate crystal-induced ...
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Role of the NLRP3 inflammasome in the transient release of IL-1β induced by monosodium urate crystals in human fibroblast-like synoviocytes
... clinic, crystals are present, and may be retrieved by aspirating the synovial fluid (SF) of gout patients, during gout flares, but also during asymp- tomatic periods ...of crystals in the SF and the ...
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The lack of association between the burden of monosodium urate crystals assessed with dual energy computed tomography or ultrasonography with cardiovascular risk in the commonly high risk gout patient
... MSU crystals and that modifications of this coating has implications on the inflammatory response to the presence of these crystals ...circulating urate but are also possibly involved in MSU ...
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Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout.
... of monosodium urate crystals with any of the following: frequent recurrent gout flares, chronic gouty arthritis, subcutaneous tophi or imaging disease elements of ...that urate lowering ...
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Performance of gout definitions for genetic epidemiological studies: analysis of UK Biobank
... of monosodium urate crystals as the gold standard for gout definition, reported that the definition of self-report of gout or urate-lowering therapy (ULT) use had the best test performance ...
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Disease associated particulates and joint inflammation; mechanistic insights and therapeutic targets
... Monosodium urate crystals induce matrix metalloprotease (MMP) expression by chondrocytes (13), prostaglandin, and CCL2 production by fibroblasts and synoviocytes (14) and TGFβ1, IL-6, tumor necrosis ...
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Modulation of monosodium urate crystal induced responses in neutrophils by the myeloid inhibitory C type lectin like receptor: potential therapeutic implications
... Gout is one of the most painful types of arthritis, and its prevalence is on the rise worldwide [1,2]. The inflamma- tory reaction typical of an acute gout attack is initiated by the crystallized form of a by-product of ...
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Is urate crystal precipitation a predictor of cardiovascular risk in hyperuricemic patients? A Danish cohort study
... MSU crystals during a 12-year period in Funen County, ...MSU crystals [4, 5, 32], which is in line with international recommen- dations for gout diagnosis [7, ...
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Monosodium urate burden assessed with dual energy computed tomography predicts the risk of flares in gout: a 12 month observational study
... of urate lowering therapy (ULT) are critical times for ...serum urate (SU) [12] concentration induces mobilization of the deposited MSU burden, potentially exposing the crystals to the in- nate ...
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In Vitro Growth and Inhibition Studies of Ceiba Pentandra on Monosodium Urate Monohydrate Crystals
... crystals in the experiments. FT-IR spectrum one can confirm the presence of ketone group (C = O), carbon-nitrogen bond (C-N), N-H stretching and rocking as well as the presence of water of hydration in the sample, ...
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Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives
... IL-1 β is known to play a causative role in many of the NLRP3 inflammasome-related diseases. For example, in mice suffering from atherosclerosis, IL-1 β plays a role in stimulating lipid plaque development and ...
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Factors influencing the crystallization of monosodium urate: a systematic literature review
... sodium urate at different pH levels were left to equili- brate and uric acid concentrations were used to calculate ...but urate solubility was reported to be greater at pH levels ≤6 or ≥10, with minimal ...
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miR 155 is dispensable in monosodium urate induced gouty inflammation in mice
... and TNF-α were elevated within 2 h and peaked at 4 h [18]. Given that elevated levels of miR-155 are involved in MSU-induced gouty inflammation, we hypothesized that loss of miR-155 may reduce the inflammatory medi- ator ...
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Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre clinical model for gout prophylaxis?
... To test for anti-inflammatory effects of CS, macrophages were pretreated with highly purified bovine chondroitins 4 and 6 sulfate of ≥98% purity, and with an average mo- lecular weight of ~ 15–16 kDa (Bioibérica, ...
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