Mouse pancreas and beta-cell development
Pancreas and beta cell development: from the actual to the possible
... -cell development has itself raised almost as many questions as it has ...and cell types can a single Ngn3 + cell contribute? Although novel technical approaches are clearly required, for ...
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6-6-2011 12:00 AM The Effects of Low Protein during Gestation on Mouse Pancreas Development and Beta Cell Regeneration
... Thus far the studies have examined the administration of a LP diet during gestation and lactation and while both periods are critical times for endocrine pancreas development, studies have tried to ...
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MFng Is Dispensable for Mouse Pancreas Development and Function
... pancreatic cell differentiation, and mutations of various Notch signaling components result in perturbed pancreas ...three mouse Fringe genes in the developing mouse pancreas between ...
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Regulators of Mouse and Human Beta Cell Proliferation
... Although mouse genetics has provided mounting knowledge of the general functions of many key transcription factors, including PDX1, ...generate beta cells from hES or iPSC have surpassed several milestones, ...
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Molecular mechanisms of pancreas development and insulin regulation in beta cells.
... well cell culture plate in which were placed polyornithine-treated coverslip and treated with 2 nM Act-A and 500 pM HGF for 48 ...RINm5F cell line has been used as a positive control for the ...
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Signals from the neural crest regulate beta cell mass in the pancreas
... regulate beta-cell mass in the pancreas Nada Nekrep 1 , Juehu Wang 1 , Takeshi Miyatsuka 1 and Michael ...endoderm-derived pancreas, we defined the chronology of migration and differentiation ...
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Non-neural tyrosine hydroxylase, via modulation of endocrine pancreatic precursors, is required for normal development of beta cells in the mouse pancreas
... during development [36, 37], including cells found in the stomach and duodenum [36] that express both TH and neurofilament ...embryonic cell type with a non-neuronal endocrine phenotype, as evidenced by the ...
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Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas
... exocrine cell types from a common progenitor pool, as well as the iterative influence of Notch signaling in regulating these ...acinar cell differentiation is ...acinar cell differentiation ...
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GATA4 and GATA6 control mouse pancreas organogenesis
... in pancreas formation, we have conditionally inactivated these genes in the pancreatic progenitor domain via Cre/lox technol- ...in pancreas morphogenesis, the inacti- vation of both Gata4 and Gata6 in the ...
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Regulation of primordial germ cell development in the mouse
... ment of PGCs. We have learnt that throughout the migratory period, PGCs receive signals from the surrounding somatic cells that: 1) secure their survival (at the same time perhaps promoting their apoptotic degeneration ...
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Endodermal progenitor cells isolated from mouse pancreas
... murine pancreas is found to overlap with ductal areas positive for ...early cell culture experiments all of the Sca-PPC colonies are posi- tive for ...the pancreas, ...
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Elucidating the Role of Menin During Islet Cell Development in the Human Fetal Pancreas
... each cell population level, as well as their proliferation capacity, could be performed in future ...studies. Cell sorting techniques as well as nuclear/cytoplasmic extractions could give a more precise ...
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GDF11 modulates NGN3+ islet progenitor cell number and promotes β cell differentiation in pancreas development
... Identification of unequivocal pancreatic endocrine defects arising from Gdf11 or Smad2 haploinsufficiency suggests that developing islet progenitor cells are particularly sensitive to perturbations in TGF- β signaling, ...
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Vascular instruction of pancreas development
... for pancreas specification, more recent work has demonstrated that, surprisingly, they act to restrain outgrowth and morphogenesis of the pancreatic epithelium at later developmental ...vessel development ...
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Development of a Bioartificial Vascular Pancreas
... Introduction Type 1 diabetes results from the autoimmune destruction of pancreatic islets and is a growing and chronic health problem throughout the world. 1,2 Monitoring of blood sugar levels, and recurrent intervention ...
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Organ-specific barcodes in human fetal development and stem cell differentiation : the pancreas in the spotlight
... different cell types in the human body. The type and function of a cell is determined by their protein makeup, which is a product of gene expression: each cell specifically regulates its ...
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Expression of regulatory genes for pancreas development during murine embryonic stem cell differentiation
... 1 Cell Differentiation Unit (DIFF) and 2 Laboratory of Cell Genetics (CEGE), Vrije Universiteit Brussel (VUB), Brussels, Belgium ABSTRACT Insulin-producing cells derived from embryonic stem cells could be ...
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Imaging heterogeneity in the mitochondrial redox state of premalignant pancreas in the pancreas-specific PTEN-null transgenic mouse model
... We also observed lower levels of Fp and NADH in the PTEN-null group (Table 2). Decreased Fp and NADH is probably partially due to decreased cell density in pre- malignant tissues which had various sizes of ductal ...
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Generation of Functional Beta-Like Cells from Human Exocrine Pancreas
... the mouse, during the late stages of pancreatic development, the interplay between the TFs Arx and Pax4 determines the establishment of either the α- or β-cell lineages ( Fig 2A ) [ 38 ...
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Wnt5 signaling in vertebrate pancreas development
... insulin expression (Fig. 2E,F). None of the fz-2 mRNA- injected embryos (n = 81) displayed scattered insulin expression (Fig. 2E,H). In contrast, co-injection of fz-2 MO and fz-2 mRNA resulted in a significantly lower ...
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