mRNA decay
Picornavirus Modification of a Host mRNA Decay Protein
... host mRNA decay-associated protein identi- fied to interact with picornavirus RNA and possibly act as a player in picornavi- rus ...Other mRNA decay pro- teins, including the decapping enzyme ...
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5′ to 3′ mRNA Decay Factors Colocalize with Ty1 Gag and Human APOBEC3G and Promote Ty1 Retrotransposition
... FIG. 5. 5 ⬘ to 3 ⬘ mRNA decay factors facilitate Ty1 retrotransposition posttranslationally. (A) Southern blot analysis of SphI-digested genomic DNA extracted from two independent isolates of strain JC3212 ...
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mRNA Decay during Herpesvirus Infections: Interaction between a Putative Viral Nuclease and a Cellular Translation Factor
... ence of coprecipitated proteins by Western blotting using the reciprocal antibody. Previous studies have shown that small amounts of the Vhs protein are produced in cells transfected with the wild-type UL41 allele, while ...
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The mRNA Decay Pathway Regulates the Expression of the Flo11 Adhesin and Biofilm Formation in Saccharomyces cerevisiae
... The mRNA decay pathway is important for the control of mRNA stability and translation (Goldstrohm and Wickens ...NOT mRNA deadenylase complex, which shortens the mRNA poly(A) tail as ...
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Cellular mRNA Decay Protein AUF1 Negatively Regulates Enterovirus and Human Rhinovirus Infections
... AUF1. While we have determined that AUF1 has an overall inhib- itory effect on enterovirus/rhinovirus infection, the precise mech- anism of this negative regulation is unknown. Defining the mech- anism of AUF1 regulation ...
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Human alternative Klotho mRNA is a nonsense-mediated mRNA decay target inefficiently spliced in renal disease
... that mRNA transcripts with PTCs are tar- gets for nonsense-mediated mRNA decay ...all mRNA molecules and is displaced by the ribosome during the pioneer round of translation ...aberrant ...
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Loss of translational control in yeast compromised for the major mRNA decay pathway
... specific mRNA(s) might be upregulated in mRNA decay mutants and have direct effects upon translational ...the mRNA decay mutants have global effects on the gene expression profile of ...
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Regulation of Natural mRNAs by the Nonsense-Mediated mRNA Decay Pathway
... nonsense-mediated mRNA decay (NMD) pathway is a specialized mRNA degradation pathway that degrades select ...the mRNA, NMD is now also recognized as a pathway that degrades some natu- ral ...
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Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay and its association to intellectual disability
... transcription, mRNA processing, translation, and deg- radation ...RNA decay pathways have been identified ...tic mRNA decay pathways, the 5′ to 3′ and the 3′ to 5’ mRNA decay, ...
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A Role for the Nonsense-Mediated mRNA Decay Pathway in Maintaining Genome Stability in Caenorhabditis elegans
... Nonsense-mediated mRNA decay (NMD) acts immediately after mRNAs are exported at the first pioneer round of ...to mRNA unwinding and protein removal, followed by mRNA cleavage via the SMG6 ...
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Conservation of Nonsense-Mediated mRNA Decay Complex Components Throughout Eukaryotic Evolution
... Nonsense-mediated mRNA decay (NMD) is an essential eukaryotic process regulating transcript quality and abundance, and is involved in diverse processes including brain development and plant ...
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Post transcriptional control by bacteriophage T4: mRNA decay and inhibition of translation initiation
... code, mRNA, and tRNA; the very foundations of molecular ...in mRNA decay and processing, and on translational ...nucleotide mRNA sequence; phage exclusion systems that involve T4-mediated ...
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Gene Set Coregulated by the Saccharomyces cerevisiae Nonsense-Mediated mRNA Decay Pathway
... nonsense-mediated mRNA decay (NMD) pathway has historically been thought of as an RNA surveil- lance system that degrades mRNAs with premature translation termination codons, but the NMD pathway of ...
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Assessing the activity of nonsense-mediated mRNA decay in lung cancer
... nonsense-mediated mRNA decay (NMD) in tumor cells can suppress tumor growth through expressing new antigens whose mRNAs otherwise are degraded by ...
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Nonsense mediated mRNA decay affects nonsense transcript levels and governs response of cystic fibrosis patients to gentamicin
... Aminoglycosides can readthrough premature termination codons (PTCs), permitting translation of full- length proteins. Previously we have found variable efficiency of readthrough in response to the aminogly- coside ...
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Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay
... of NMDI1 and have found that our compound, VG1 , inhibited NMD to the same extent as NMDI1 . Our synthesis requires only 6 steps and proceeds in 18% overall yield. Lejeune and co-workers presented evidence that NMDI1 ...
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Dynamic regulation of mRNA decay during neural development
... via mRNA decay. For example, growth cone-localized Robo3.2 mRNA is degraded by the NMD pathway when axons encounter the spinal cord floor plate ...of mRNA decay is also important for ...
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Premature termination codons in PRPF31 cause retinitis pigmentosa via haploinsufficiency due to nonsense mediated mRNA decay
... the mRNA splicing factor PRPF31 cause retinitis pigmentosa, a hereditary form of retinal ...nonsense-mediated mRNA decay significantly restored the amount of mutant PRPF31 mRNA but did not ...
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A role for nonsense mediated mRNA decay in plants : pathogen responses are induced in Arabidopsis thaliana NMD mutants
... extensively alternatively spliced and regulation of R gene splicing is critical for plant immunity [81–83]. It is probable that NMD targets splice variants that contain premature termination codons. If R gene splice ...
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Real-time RT-PCR analysis of mRNA decay: half-life of Beta-actin mRNA in human leukemia CCRF-CEM and Nalm-6 cell lines
... β-actin mRNA molecules were calculated for each time-point and plotted as a function of time (Figure ...-actin mRNA exhibited a half-life of ...β-actin mRNA half-life between these two cell ...and ...
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